Establishment of treatment by regeneration and suppressing degeneration in human intervertebral disc.
| Project/Area Number |
16K10816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Toyama |
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Principal Investigator |
SEKI Shoji 富山大学, 大学院医学薬学研究部(医学), 助教 (00432112)
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| Co-Investigator(Kenkyū-buntansha) |
川口 善治 富山大学, 大学院医学薬学研究部(医学), 准教授 (00262527)
箭原 康人 富山大学, 附属病院, 医員 (60456390)
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| Research Collaborator |
NOGAMI makiko
MAKINO hiroto
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | AP-1阻害剤 / 腰椎椎間板 / 椎間板穿刺モデル / 腰痛症 / 脊椎脊髄病学 |
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| Outline of Final Research Achievements |
Lumbar intervertebral disc (IVD) degeneration is attributable mainly to LBP, called discogenic pain, which often leads to disc herniation presenting as sciatica. We investigated the effects of inhibition of c-Fos/AP-1（T-5224）on IVD degeneration and associated pain. We used a tail disc percutaneous needle puncture method to further assess the effects of oral administration of T-5224 on IVD degeneration. Analysis of x-ray, MRI findings, and histology revealed that IVD degeneration was significantly mitigated by T-5224. Further, oral administration of T-5224 ameliorated pain as indicated by the extended tail-flick latency in response to heat stimulation of rats with needle-puncture-induced IVD degeneration. T-5224 prevented disc degeneration, and oral administration of T-5224 extended the tail flick latency as a measure of heat stimulation in the rat tail-puncture model. These findings suggest that the inhibition of c-Fos/AP-1 prevents disc degeneration and its associated pain.
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| Academic Significance and Societal Importance of the Research Achievements |
腰椎椎間板変性は、脊柱管狭窄症、ヘルニア、腰痛の原因の一つである。これらの疾患は若年-中高年まで労働生産性の高い年代に患うことが多い。現在臨床応用可能な椎間板変性抑制の薬はなく、早期臨床応用可能な治療法の開発は急務である。椎間変性が抑制できれば、多くの腰痛や狭窄症に悩む患者にとって非常に朗報である。c-fos/AP-1阻害薬（T-5224）は、動物実験レベルでは椎間板変性抑制作用とその関連痛を抑制した。この薬は実際にヒトへの投与も可能であり、実際に臨床的効果が得られれば、労働生産性の向上など社会的利益も大きい点で、極めて有益な研究であると確信する。
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Report
(4 results)
Research Products
(99 results)
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[Journal Article] Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: a multicenter study (JOSL CT study)2018
Author(s)
Hirai T, Yoshii T, Nagoshi N, Takeuchi K, Mori K, Ushio S, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Ando K, Fujibayashi S, Koda M, Yamazaki M, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y.
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Journal Title
BMC Musculoskeletal Disorders
Volume: 19(1)
Pages: 107-107
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fall-related Deterioration of Subjective Symptoms in Patients with Cervical Myelopathy2017
Author(s)
Kimura A, Seichi A, Takeshita K, Inoue H, Kato T, Yoshii T, Furuya T, Koda M, Takeuchi K, Matsunaga S, Seki S, Ishikawa Y, Imagama S, Yamazaki M, Mori K, Kawasaki Y, Fujita K, Endo K, Sato K, Okawa A.
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Journal Title
DOI
Related Report
Peer Reviewed
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[Journal Article] 脊柱変形の病態別に見た脊椎矯正手術におけるアラームポイントの検討 －日本脊椎脊髄病学会脊髄モニタリングワーキンググループ 多施設前向き研究－2016
Author(s)
山田圭, 松山幸弘, 小林祥, 長濱賢, 和田簡一郎, 田所伸朗, 村本明生, 寒竹司, 岩崎博, 関庄二, 平尾雄二郎, 溝田敦子, 安藤宗治, 山本直也, 角谷智, 大田亮, 伊藤全哉, 藤原靖, 木田和伸, 高橋雅人, 川端茂徳, 齋藤貴徳, 谷俊一, 里見和彦, 四宮謙一
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Journal Title
J Spine Res.
Volume: 7
Pages: 901-907
Related Report
Peer Reviewed
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