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Reconstruction of the tendon-bone junction with tubular titanium web:A miniature swine model study

Research Project

Project/Area Number 16K10877
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionJikei University School of Medicine

Principal Investigator

MARUMO KEISHI  東京慈恵会医科大学, 医学部, 教授 (70199925)

Co-Investigator(Kenkyū-buntansha) 池田 亮  東京慈恵会医科大学, 医学部, 講師 (20439772)
齋藤 充  東京慈恵会医科大学, 医学部, 准教授 (50301528)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsチタン再繊維 / 腱・骨接合部 / 再建靱帯 / ミニブタ / チタン細繊維 / 円筒状チタンウェッブ / enthesis / 再生 / 円筒形チタン細繊維 / 円筒形チタンウエッブ / 円盤状チタンウエッブ
Outline of Final Research Achievements

We performed reconstruction of the tendon-bone junction using the tubular titanium-web (TW) made from titanium microfibers. Four months postoperatively tendon-like and bone-like tissue ingrowth was observed within the TW in histological specimens. Furthermore, since maturity of the ingrowing tissue within the tendon matrix, the titanium-web and the bone was similar to the normal tissue, we confirmed that bone and tendon could be joined by the TW. The reconstruction occurred not because of impaired maturity of collagen, the main structural component of tendons and bones, but due to formation of a tissue matrix containing tissue-specific collagen cross-links patterns.

Academic Significance and Societal Importance of the Research Achievements

移植腱がリモデリングにより靱帯様組織に変化していく際に、早期に靱帯特有の架橋のパターンを誘導し、かつ十分な架橋の形成を促進することは、本来の靱帯の機能を取り戻すためには重要である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2019 2016

All Presentation (2 results) (of which Invited: 1 results)

  • [Presentation] チタン細繊維からなる円筒状チタンウェッブは腱・骨結合部の再生・固着を促進する-ミニブタを用いた検討-2019

    • Author(s)
      劉啓正, 丸毛啓史, 斎藤充
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 膝関節内靱帯再建術の課題 -移植腱組織の靱帯化促進とenthesis再建-2016

    • Author(s)
      丸毛啓史
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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