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Inhibitory effect of the multiple receptor tyrosine kinase inhibitor on osteoarthritis

Research Project

Project/Area Number 16K10919
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokai University

Principal Investigator

NAGAI Toshihiro  東海大学, 医学部, 講師 (20514376)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords関節軟骨修復 / 変形性関節症 / 血管新生阻害剤 / multipleチロシンキナーゼ受容体阻害剤 / 変形性関節症修復剤 / multiple チロシンキナーゼ受容体阻害剤 / mutipleチロシンキナーゼ受容体阻害剤
Outline of Final Research Achievements

We investigated the efficacy of a multiple receptor tyrosine kinase (mRTKs)inhibitor which was developed in Japan, in the treatment of osteoarthritis (OA) using a rabbit model of ACLT. mRTKs had no negative effect (e.g., diarrhea and vomiting) in normal rabbits. Histologically, administration of mRTKs group exhibited a reduction in articular cartilage degeneration and less osteophyte formation and synovitis compared with the control group (OA group). And assessment of pain behavior showed a superior effect in the administration of mRTKs group compared with the OA group 12 weeks after administration of mRTKS.

Academic Significance and Societal Importance of the Research Achievements

変形性関節症(OA)はその進行予防が極めて重要であるが、末期OAに至るまでの初期から中等度OAに対する薬物療法は、疼痛改善を主眼としており軟骨変性を抑制し疾患の進行を抑止しうるには至らず、OAの進行が余儀なくされている。mRTKs inhibitorは疼痛改善効果のみならず、良好な関節軟骨修復効果(軟骨変性抑制効果と滑膜炎抑制効果と骨棘形成抑制効果)が見込まれ、病勢を抑止する可能性がある新規の治療法である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017

All Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Inhibitory effect of lenvatinib, a multiple receptor tyrosine kinase inhibitor, on osteoarthritis2018

    • Author(s)
      Yasuyuki Sogo, Toshihiro Nagai, Takumi Takahashi, Daichi Takizawa, Masahiko Watanabe, Masato Sato
    • Organizer
      The 2018 Osteoarthritis Research Society International (OARSI) World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多標的チロシンキナーゼ受容体阻害薬Lenvatinibによる変形性関節症抑制効果2018

    • Author(s)
      十河泰之 長井敏洋 佐藤正人 高橋匠 滝澤大智 岡田恵理 前原美樹 豊田恵利子
    • Organizer
      第33回日本整形外科学会基礎学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 後方進入椎体間固定術の下位腰椎椎間における前弯獲得について:使用ケージの形状の差による比較検討2018

    • Author(s)
      長井敏洋 酒井大輔 新井文征 佐藤正人 渡辺雅彦
    • Organizer
      第27回 日本脊椎インストゥルメンテーション学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 12°wedge cage・boomerang cage・box cageによる後方進入椎体間固定術後の局所前弯角の検討2018

    • Author(s)
      長井敏洋 新井文征 佐藤正人 渡辺雅彦
    • Organizer
      第67回 東日本整形災害外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The effect of cage geometry on segmental lordosis in posterior lumbar interbody fusion: hyper-lordotic box cages versus boomerang cages2018

    • Author(s)
      Toshihiro Nagai, Daisuke Sakai, Yukihiro Yamamoto, Masato Sato, Masahiko Watanabe
    • Organizer
      45th ISSLS Annual Meeting - Banff, Canada, 14th - 18th May 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] VEGF受容体チロシンキナーゼ阻害剤 Lenvatinibによる滑膜炎抑制効果2017

    • Author(s)
      十河泰之 長井敏洋 佐藤正人 高橋匠 滝澤大智 岡田恵里 前原美樹 豊田恵利子 渡辺雅彦
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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