| Project/Area Number |
16K10936
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
EGI MORITOKI 神戸大学, 医学研究科, 准教授 (20423296)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
廣田 勇士 神戸大学, 医学部附属病院, 助教 (80566018)
|
|---|
| Research Collaborator |
Wakabayashi Junji
Furushima Nana
Hokka Mai
Mizobuchi Satoshi
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 血糖 / 変動 / 敗血症 / 糖尿病 / 好中球機能 / 酸化ストレス / 血糖管理 / 急性期 / 血糖変動 |
|---|
| Outline of Final Research Achievements |
We observed HbA1c level in septic patients required intensive care more than 48 hours. We have measured blood glucose using continuous glucose monitoring for first 48 hours. We performed regression analysis between various glycemic indices and neutrophil function and oxidative stress. We found that there are significant relationship between relative hypoglycemia and Neutrophil sterilizing ability （r=0.503, p<0.01). We also found that there are significant association between the mean amplitude of glycemic excursions (MAGE) as index of glycemic variability and oxidative stress （r=0.412, p<0.01).
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究では、敗血症診療の初期における血糖管理において、敗血症発症前の血糖管理を加味した血糖降下指数と好中球機能および酸化ストレスとの関係を検討した。敗血症診療中の血糖そのものだけではなく、病前血糖値を加味した指数の方が好中球機能および酸化ストレスとより強い関連を示した。これらの結果は、敗血症診療における至適な血糖管理を検討する上で、有益な情報であり、新たな血糖管理目標を提言する上で重要な情報となりうる。
|
