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Perioperative treatment strategy by analyzing blood flow and energy loss using multiple imaging modality

Research Project

Project/Area Number 16K10970
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Ishii Maki  京都府立医科大学, 医学(系)研究科(研究院), 助教 (50457959)

Co-Investigator(Kenkyū-buntansha) 佐和 貞治  京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
板谷 慶一  京都府立医科大学, 医学(系)研究科(研究院), 講師 (70458777)
沼田 智  京都府立医科大学, 医学(系)研究科(研究院), 助教 (80735689)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsシアストレス / vector flow mapping / エネルギー損失 / wall shear stress / kinetic energy / IVPD / 左室補助人工心臓 / Vector flow mapping / コンピュータシミュレーション / 4D MRI / 運動エネルギー / エネルギー効率 / 4D MRI / 周術期管理学
Outline of Final Research Achievements

We established the methodology that wall shear stress on aortic valve and aortic root can be analyzed by epiaortic echo using vector flow mapping.

Academic Significance and Societal Importance of the Research Achievements

様々な疾患でシアストレスの異常で大動脈弁や大動脈壁の変性やアテローム化が起こることが知られているが、老年性の石灰化などは大動脈側の組織に起こり、左室補助人工心臓埋め込み後の患者では左室側の組織に起こる。我々の開発した手法でシアストレスを解析することで、さらに詳細な原因検索とより良い治療方法を探ることができる可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (34 results)

All 2020 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (26 results) (of which Int'l Joint Research: 14 results,  Invited: 1 results)

  • [Journal Article] A novel in vivo assessment of fluid dynamics on aortic valve leaflet using epi-aortic echocardiogram2020

    • Author(s)
      Hayashi H, Akiyama K, Itatani K, Deroo S, Sanchez J, Ferrari G, Colombo PC, Takeda K, Wu IY, Kainuma A, Takayama H
    • Journal Title

      Echocardiography

      Volume: 37 Issue: 2 Pages: 323-330

    • DOI

      10.1111/echo.14596

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Energetic performance index improvement after Glenn and Damus-Kaye-Stansel procedure using vector flow mapping analysis: a case report2020

    • Author(s)
      Kainuma A, Akiyama K, Naito Y, Hayase K, Hongu H, Itatani K, Yamagishi M, Sawa T
    • Journal Title

      Journal of Anesthesia Clinical Reports

      Volume: 6 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s40981-020-0312-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Flow energy loss evaluation in a systolic anterior motion case after the Ross procedure2017

    • Author(s)
      Akiyama K, Naito Y, Kinoshita M, Ishii M, Nakajima Y, Itatani K, Miyazaki T, Yamagishi M, Yaku H, Sawa T
    • Journal Title

      Journal of Cardiothoracic and Vascular Anesthesia

      Volume: 印刷中 Issue: 6 Pages: 2118-2122

    • DOI

      10.1053/j.jvca.2017.03.006

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Visualization of suppressed intraventricular flow by constrictive pericarditis2017

    • Author(s)
      Akiyama K, Itatani K, Yamashita A, Sawa T
    • Journal Title

      Journal of Clinical Anesthesia

      Volume: 42 Pages: 40-41

    • DOI

      10.1016/j.jclinane.2017.08.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Energetic performance analysis of staged palliative surgery in tricuspid atresia using vector flow mapping2017

    • Author(s)
      Kinoshita M, Akiyama K, Itatani K, Yamashita A, Ishii M, Kainuma A, Maeda Y, Miyazaki T, Yamagishi M, Sawa T
    • Journal Title

      Cardiovasc Ultrasound

      Volume: 15 Issue: 1 Pages: 27-27

    • DOI

      10.1186/s12947-017-0118-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Flow-dynamics assessment of mitral-valve surgery by intraoperative vector flow mapping2017

    • Author(s)
      Akiyama K, Nakamura N, Itatani K, Naito Y, Kinoshita M, Shimizu M, Hamaoka S, Kato H, Yasumoto H, Nakajima Y, Mizobe T, Numata S, Yaku H, Sawa T.
    • Journal Title

      Int Cardiovasc Thorac Surg

      Volume: in press Issue: 6 Pages: 869-875

    • DOI

      10.1093/icvts/ivx033

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vector flow mapping analysis of left ventricular energetic performance in healthy adult volunteers2017

    • Author(s)
      Akiyama K, Maeda S, Matsuyama T, Kainuma A, Ishii M, Naito Y, Kinoshita M, Hamaoka S, Kato H, Nakajima Y, Nakamura N, Itatani K, Sawa T
    • Journal Title

      BMC Cardiovascular Disorders

      Volume: 17 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s12872-016-0444-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vector flow mapping and impaired left ventricular flow by Alfieri stitch.2017

    • Author(s)
      Akiyama K, Itatani K, Naito Y, Kinoshita M, Shimizu M, Hamaoka S, Yasumoto H, Kato H, Nakajima Y, Numata S, Yaku H, Sawa T.
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: in press Issue: 1 Pages: 211-214

    • DOI

      10.1053/j.jvca.2016.07.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Mechanical Circulatory Supportの不思議: 麻酔科医としての必須知識とこれからの研究課題2019

    • Author(s)
      秋山浩一
    • Organizer
      日本心臓血管麻酔学会第24回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大会長企画2 近未来のTEE: 最新の血流解析 Vector Flow Mappingの基礎から臨床まで2019

    • Author(s)
      秋山浩一
    • Organizer
      日本心臓血管麻酔学会第24回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 左室補助人工心臓埋め込み術中におけるIntraventricular Pressure Difference (IVPD)のramp testによる変化2019

    • Author(s)
      秋山浩一
    • Organizer
      日本心臓血管麻酔学会第24回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 慢性大動脈弁逆流における左室エナジーロスは患者の自覚症状を反映する2019

    • Author(s)
      甲斐沼篤
    • Organizer
      日本心臓血管麻酔学会第24回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Intravenrticular Pressure Difference assessment from color M-mode image using transesophageal echocardiography2019

    • Author(s)
      秋山浩一
    • Organizer
      International Anesthesia Research Society 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preoperative left ventricular energy loss in the operating theater reflects subjective symptoms in patients with chronic aortic regurgitation.2019

    • Author(s)
      甲斐沼篤
    • Organizer
      International Anesthesia Research Society 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic vasoreactivity in the middle cerebral artery of heart failure patients with and without continuous-flow left ventricular support.2019

    • Author(s)
      Ruiping Ji
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Assessment of wall shear stress on the aortic valve in patients with left ventricular assist device using vector flow mapping.2019

    • Author(s)
      秋山浩一
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Blood flow kinetic energy of right ventricular outflow tract: A marker for right ventricular global systolic function.2019

    • Author(s)
      秋山浩一
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wall shear stress in the middle cerebral artery of HMⅡ patients - A prospective, mechanistic study using vector flow mapping.2019

    • Author(s)
      秋山浩一
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparison of middle cerebral artery and central retinal artery hemodynamics in HMⅡ patients.2019

    • Author(s)
      Eric J Stohr
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel approach to assess intraventricular pressure difference in patients with left ventricular assist device during ramp study.2019

    • Author(s)
      秋山浩一
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wall shear stress in the middle cerebral artery of HMⅡ patients - A prospective, mechanistic study using vector flow mapping.2019

    • Author(s)
      秋山浩一
    • Organizer
      International Society of Heart and Lung Transplantation 39th annual meeting 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Energetic performance index improvement after Glenn and Damus-Kauye-Stansel procedure using vector flow mapping analysis.2018

    • Author(s)
      甲斐沼篤
    • Organizer
      International Anesthesia Research Society 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of aortic regurgitation jet directionality on energy loss.2018

    • Author(s)
      秋山浩一
    • Organizer
      International Anesthesia Research Society 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 経食道心エコーによるIntraventricular Pressure Differenceの解析2018

    • Author(s)
      秋山浩一
    • Organizer
      日本心臓血管麻酔学会第23回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 左室補助人工心臓(LVAD)による大動脈弁のwall shear stressの変化と変性2018

    • Author(s)
      秋山浩一
    • Organizer
      日本心臓血管麻酔学会第23回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Kinetic energy and energy loss in the middle cerebral artery(MCA) of HeartMateⅡ patients.2018

    • Author(s)
      秋山浩一
    • Organizer
      Artery 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Vector Flow Mappingによる収縮性心膜炎における収縮機能不全評価2017

    • Author(s)
      秋山浩一、山下理比路、甲斐沼篤、木下真央、加藤秀哉、濱岡早枝子、内藤慶史、佐和貞治
    • Organizer
      第44回日本集中治療医学会学術集会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2017-03-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 段階的姑息術におけるEnergetic Performanceの推移2016

    • Author(s)
      秋山浩一
    • Organizer
      第11回京滋心臓血管術中エコー研究会
    • Place of Presentation
      京都府立医科大学
    • Year and Date
      2016-11-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 単心室におけるエネルギー効率(若手研究奨励講演)2016

    • Author(s)
      秋山浩一、谷口文香、内藤慶史、木下真央、加藤秀哉、甲斐沼篤、板谷慶一、山岸正明、佐和貞治
    • Organizer
      日本小児麻酔学会第22会大会
    • Place of Presentation
      新横浜国際ホテル
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 術中リアルタイムVector Flow Mappingを用いた僧帽弁手術評価の展望(藤田昌雄賞候補セッション)2016

    • Author(s)
      秋山浩一、甲斐沼篤、木下真央、内藤慶史、板谷慶一、中村直俊、中嶋康文、溝部俊樹、佐和貞治
    • Organizer
      日本心臓血管麻酔学会第21回学術大会
    • Place of Presentation
      横浜ベイホテル東急
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 術中Vector Flow Mappingを用いたSAM原因の究明(藤田昌雄賞候補セッション)2016

    • Author(s)
      秋山浩一、石井真紀、加藤秀哉、甲斐沼篤、板谷慶一、中村直俊、中嶋康文、溝部俊樹、佐和貞治
    • Organizer
      日本心臓血管麻酔学会第21回学術大会
    • Place of Presentation
      横浜ベイホテル東急
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 左室内Vortex Patternとエネルギー損失基準値の策定2016

    • Author(s)
      秋山浩一、前田祥子、内藤慶史、甲斐沼篤、溝部俊樹、佐和貞治
    • Organizer
      日本麻酔科学会第63回学術集会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Definition of normal vortex and energy loss reference value in left ventricle using vector flow mapping2016

    • Author(s)
      Akiyama K, Maeda S, Naito Y, Kato H, Kinoshita M, Shimizu M, Sawa T,
    • Organizer
      International Anesthesia Research Society
    • Place of Presentation
      Hilton San Francisco
    • Year and Date
      2016-05-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mitral valve replacement impairs left ventricular blood flow2016

    • Author(s)
      Akiyama K, Itatani K, Kinoshita M, Shimizu M, Hamaoka S, Kato H, Naito Y, Nakajima Y, Numata S, Mizobe T, Yaku H, Sawa T
    • Organizer
      American College of Cardiology
    • Place of Presentation
      Maccormic Place Chicago
    • Year and Date
      2016-04-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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