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Exploring the central mechanism of chronic pain (Nociplastic pain) using MRI

Research Project

Project/Area Number 16K10980
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionGunma University

Principal Investigator

Ogino Yuichi  群馬大学, 医学部附属病院, 講師 (20420094)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMRI / 脳 / 可塑性 / 機能的繋がり / 構造 / 共感 / 脳科学 / 運動 / 痛み / 疼痛 / 中枢機能障害性疼痛 / 非器質的疼痛 / 慢性痛 / 抗うつ薬 / 脳機能 / 脳構造 / fMRI / 非定型 / 顎関節症 / 口腔顔面痛 / 麻酔 / スポーツ医学
Outline of Final Research Achievements

Through the current study project: Exploring the central mechanism of chronic pain (Nociplastic pain) using MRI, we investigated our object : making clear the mechanism of nociplastic pain that its organic pathology is unknown, using magnetic resonance imaging (MRI). Using voxel-based morphometry (VBM) and resting-state MRI and diffusion tensor imaging (DTI) technique, we acquired 3-tesla MRI of the atypical orofacial pain patients. These acquired data are now under analysis, summing of the results and the preparation of publication. Another achievement is the study regarding neuroplasticity in elite athletes. We clarified the structural and functional plasticity in professional boxers and its widely distributed functional connectivity were enhanced by Body-Mass-Index decrease, implying the significance of weight-making in pre-match period. The publication was conducted in Neuroscience 2018 at San Diego, CA, U.S.A.

Academic Significance and Societal Importance of the Research Achievements

研究成果の社会的意義と重要性として、研究結果をすぐに臨床にもフィードバックすることができ、患者からの結果要請にも積極的に応えていき、これまで「心因性」と説明しても納得することがなかった患者さんに、“脳機能障害性痛”という新しい痛みの要素と病態メカニズムを説明できるようになった。その臨床的意義は引き続き継続し、ペインクリニック臨床と痛み診療において、疾患の概念を最新のものとし、「認知性疼痛」として新たな痛みのメカニズム提唱へと繋がってきている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report

Research Products

(16 results)

All 2019 2018 2017 2016 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 痛みとは何か2019

    • Author(s)
      荻野祐一
    • Journal Title

      心理学ワールド

      Volume: 84 Pages: 21-22

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 機能が変わると構造も変わる - 痛みと脳可塑性2018

    • Author(s)
      荻野祐一 設楽仁 川道拓東 齋藤繁
    • Journal Title

      日本運動器疼痛学会誌

      Volume: 10 Pages: 12-17

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fibromyalgia rapid screening tool (FiRST) を使用した顎関節症と線維筋痛症の鑑別 - 顎関節症群から線維筋痛症は detect できるのか2017

    • Author(s)
      小杉謙介 荻野祐一 齋藤繁 横尾聡
    • Journal Title

      ペインクリニック誌

      Volume: 38 Pages: 653-658

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] rain morphological alternation in chronic pain patients with neuropathic characteristics.2016

    • Author(s)
      Sugimine S, Ogino Yuichi, Kawamichi H, Obata H, Saito S.
    • Journal Title

      Molecular Pain

      Volume: 12 Pages: 1-7

    • DOI

      10.1177/1744806916652408

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Being in a romantic relationship is associated with reduced gray matter density in striatum and increased subjective happiness.2016

    • Author(s)
      Kawamichi H, Sugawara S, Hamano Y, Makita K, Matsunaga M, Tanabe H, Ogino Yuichi, Saito S, Sadato N.
    • Journal Title

      Front Psychol.

      Volume: 7 Pages: 1763

    • DOI

      10.3389/fpsyg.2016.01763

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 痛みはどこで感じるのか - 特発性? 脳機能障害性?2016

    • Author(s)
      荻野祐一 杉峰里美 川道拓東 齋藤繁
    • Journal Title

      有病者歯科医療学会誌

      Volume: 43 Pages: 92-97

    • Related Report
      2016 Research-status Report
  • [Journal Article] 慢性的痛みの脳科学的考察2016

    • Author(s)
      荻野祐一
    • Journal Title

      日本頭痛学会誌

      Volume: 43 Pages: 71-72

    • Related Report
      2016 Research-status Report
  • [Journal Article] 麻酔と意識.2016

    • Author(s)
      荻野祐一 川道拓東 齋藤繁.
    • Journal Title

      麻酔

      Volume: 65 Pages: 489-494

    • Related Report
      2016 Research-status Report
  • [Presentation] Enhanced functional connectivity correlated with weight-loss at pre-match period in professional boxers2018

    • Author(s)
      Yuichi Ogino
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロボクサーの試合前後における脳密度変化と脳ネットワーク解析:スポーツ脳科学研究2017

    • Author(s)
      荻野 祐一、川道 拓東、滝沢 大介、林 南穂子、茂木 彩加、齋藤 繁
    • Organizer
      日本麻酔科学会第63回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 第一部:痛みはどこで感じるのか? 第二部:MRI研究 ー 最近の応用例2017

    • Author(s)
      荻野祐一
    • Organizer
      口腔顔面痛脳学習キャンプ(日本口腔顔面痛学会主催)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 脳科学の基礎と臨床2017

    • Author(s)
      荻野祐一
    • Organizer
      2017かみ合わせ診療科 河口湖セミナー(神奈川歯科大学)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Nurses Engage in Emotional Labor: Underlying Their Professional Empathic Neural Mechanism2016

    • Author(s)
      Y. Ogino, H. Kawamichi, T. Anzai, S. Saito
    • Organizer
      International Association for the Study of Pain: IASP 16th World Congress on Pain
    • Place of Presentation
      Pacifico Convention Center, Yokohama, Japan
    • Year and Date
      2016-09-26 – 2016-09-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 極限の脱水状態が脳に及ぼす影響―脳科学的視点2016

    • Author(s)
      荻野祐一, 滝澤大介, 中村浩司, 林南穂子, 川道拓東, 齋藤繁
    • Organizer
      日本麻酔科学会第63回学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-05-26 – 2016-05-28
    • Related Report
      2016 Research-status Report
  • [Book] 症例問題から学ぶ生理学 原書4版2018

    • Author(s)
      荻野祐一 門井雄司 鯉渕典之 下川哲昭 堀雄一 丸山芳夫 南沢享
    • Total Pages
      384
    • Publisher
      丸善出版株式会社
    • Related Report
      2018 Annual Research Report
  • [Remarks] 痛みとは何か

    • URL

      https://psych.or.jp/publication/world084/pw07

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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