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Kinematic analysis of Fear-avoidance movements under the painful conditioning

Research Project

Project/Area Number 16K10981
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionThe University of Tokyo

Principal Investigator

Sumitani Masahiko  東京大学, 医学部附属病院, 准教授 (80420420)

Co-Investigator(Kenkyū-buntansha) 四津 有人  東京大学, 医学部附属病院, 特任研究員 (30647368)
大住 倫弘  畿央大学, 健康科学部, 助教 (70742485)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords運動恐怖 / 知覚運動協応 / 3次元動作解析 / 上肢運動 / 神経科学 / 疼痛 / 臨床
Outline of Final Research Achievements

According to the pain-related fear-conditioning, time of reaching movements was longer , reflecting hesitation of movements. Not only movements immediately before painful stimuli (i.e. deceleration phase) were delayed, but also movements in the acceleration phase were delayed by pain expectation and fear. Similar results were observed in the muscular coherence, indicating that pain expectation and fear involuntarily enhances co-contraction of antagonist muscles. Such negative emotional modulation might explain ‘unnatural’ but ‘not neurological’ motor abnormalities observed in chronic pain patients.

Academic Significance and Societal Importance of the Research Achievements

運動恐怖を伴う慢性疼痛患者では、従来から知られている小脳失調などの神経学的失調運動とは異なる運動の巧緻性低下が観察される。今回の結果からは特に感覚フィードバックによる運動調節相である減速期に、上肢の主働筋と拮抗筋の同時収縮が顕著となることが示され、これが神経失調症状とは異なる巧緻性低下の原因であることを明らかにした。また、運動恐怖は運動習慣だけでなく、抑うつや自己効力感のような心理的問題にも直接的に悪影響を与えることが明らかになった。したがって、運動恐怖を改善する治療法は慢性疼痛患者の運動障害に対する治療として有用であると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 8 results) Book (1 results)

  • [Journal Article] A hypothetical explanatory sensorimotor model of bilateral limb interference2019

    • Author(s)
      Osumi Michihiro、Sumitani Masahiko、Otake Yuko、Morioka Shu
    • Journal Title

      Medical Hypotheses

      Volume: 122 Pages: 89-91

    • DOI

      10.1016/j.mehy.2018.10.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A “matched” sensory reference can guide goal-directed movements of the affected hand in central post-stroke sensory ataxia2018

    • Author(s)
      Osumi M, Sumitani M, Morioka S
    • Journal Title

      Exp Brain Res

      Volume: 236 Issue: 5 Pages: 1263-1262

    • DOI

      10.1007/s00221-018-5214-6

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fear of movement modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): a single-case study2018

    • Author(s)
      Osumi M, Sumitani M, Otake Y, Morioka S
    • Journal Title

      Medical Hypotheses

      Volume: 110 Pages: 114-9

    • DOI

      10.1016/j.mehy.2017.12.002

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CRPSのメカニズムと今後の展望2017

    • Author(s)
      住谷昌彦, 大住倫弘
    • Journal Title

      慢性疼痛

      Volume: 36 Pages: 15-20

    • Related Report
      2017 Research-status Report
  • [Journal Article] 乳がん術後遷延性疼痛による不動化のため異なる転帰をとった2症例2017

    • Author(s)
      鈴木愛枝, 住谷昌彦, 榎本有希, 穂積淳, 阿部博昭, 井上玲央, 山田芳嗣
    • Journal Title

      日本ペインクリニック学会誌

      Volume: 24 Pages: 60-3

    • NAID

      130005439578

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sensori-motor integrationと痛みの慢性化2017

    • Author(s)
      住谷昌彦, 大住倫弘, 大竹祐子
    • Journal Title

      最新医学

      Volume: 72 Pages: 1034-8

    • Related Report
      2017 Research-status Report
  • [Journal Article] Optimal control of reaching is disturbed in complex regional pain syndrome (CRPS): a single-case study2017

    • Author(s)
      Osumi H, Sumitani M, Kumagaya S, Morioka S
    • Journal Title

      J Pain Res

      Volume: 10 Pages: 167-73

    • Related Report
      2016 Research-status Report
  • [Journal Article] 脊髄障害性疼痛の神経ブロック治療2016

    • Author(s)
      井上玲央, 阿部博昭, 住谷昌彦
    • Journal Title

      J Clin Rehab

      Volume: 25 Pages: 559-63

    • Related Report
      2016 Research-status Report
  • [Journal Article] 慢性疼痛疾患の診断2016

    • Author(s)
      井上玲央, 住谷昌彦
    • Journal Title

      最新医学

      Volume: 259 Pages: 49-54

    • Related Report
      2016 Research-status Report
  • [Journal Article] 痛みの原因からみた集学的アプローチ2016

    • Author(s)
      穂積淳, 阿部博昭, 井上玲央, 住谷昌彦
    • Journal Title

      成人病と生活習慣病

      Volume: 37 Pages: 1017-22

    • Related Report
      2016 Research-status Report
  • [Journal Article] 幻肢痛と神経リハビリテーション2016

    • Author(s)
      住谷昌彦, 大住倫弘
    • Journal Title

      医学のあゆみ

      Volume: 259 Pages: 195-6

    • Related Report
      2016 Research-status Report
  • [Journal Article] なぜ運動が慢性疼痛患者にとって必要なのか?2016

    • Author(s)
      住谷昌彦, 大住倫弘, 大竹祐子
    • Journal Title

      理学療法学

      Volume: 43 Pages: 40-1

    • NAID

      130005432386

    • Related Report
      2016 Research-status Report
  • [Presentation] Expectation of Pain Kinematically Affects Goal-directed Movements in the Pain-related Fear-conditioning Paradigm2018

    • Author(s)
      Yuki Nishi, Michihiro Osumi, Masahiko Sumitani, Arito Yozu, Shu Morioka
    • Organizer
      World Congress on Pain
    • Related Report
      2018 Annual Research Report
  • [Presentation] Perioperative factors affecting the occurrence of acute complex regional pain syndrome following limb bone fracture surgery: Data from the Japanese Diagnosis Procedure Combination database2017

    • Author(s)
      Masahiko Sumitani, Hideo Yasunaga, Kanji Uchida, Yoshitsugu Yamada
    • Organizer
      (World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
    • Place of Presentation
      イタリア
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] なぜ疼痛領域では臨床医による臨床研究が重要か?2017

    • Author(s)
      住谷 昌彦, 阿部 博昭, 穂積 淳, 横島 弥栄子, 土田 陸平
    • Organizer
      日本ペインクリニック学会 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Virtual Reality Technology Helps Treat Phantom Limb Pain by Letting a Missing, Injured Limb Move Again2017

    • Author(s)
      Masahiko Sumitani
    • Organizer
      NeuroTalk 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 難治性疼痛のリハビリテーション研究2017

    • Author(s)
      大住倫弘, 住谷昌彦
    • Organizer
      日本理学療法学会 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 神経障害性疼痛に対する 運動表象の回復による治療効果2017

    • Author(s)
      住谷昌彦, 大住倫弘
    • Organizer
      日本疼痛学会 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] CRPSの診断・病態 と今後の展望2017

    • Author(s)
      住谷昌彦
    • Organizer
      日本末梢神経学会 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 運動恐怖が運動実行プロセスを修飾する-運動学的計測を用いて-2016

    • Author(s)
      大住倫弘, 住谷昌彦, 大竹祐子, 熊谷晋一郎, 森岡周
    • Organizer
      日本運動器疼痛学会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 脊髄障害性疼痛の臨床研究2016

    • Author(s)
      住谷昌彦
    • Organizer
      日本疼痛学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] CRPSの深部組織の痛みのメカニズム2016

    • Author(s)
      住谷昌彦
    • Organizer
      日本疼痛学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 複合性局所疼痛症候群における知覚運動協応の分析‐運動学的データを用いて‐2016

    • Author(s)
      大住倫弘, 住谷昌彦, 森岡周
    • Organizer
      日本理学療法学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] なぜ運動が慢性疼痛患者にとって必要なのか?2016

    • Author(s)
      住谷昌彦
    • Organizer
      日本理学療法学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] Advances in Aging and Health Research「高齢者の感覚障害:慢性疼痛を中心に」2016

    • Author(s)
      住谷昌彦
    • Total Pages
      300
    • Publisher
      公益財団法人長寿科学振興財団
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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