Natural history of nocturia and the related facotrs among Japanese men and women

• Project/Area Number: 16K11041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of Fukui
• Principal Investigator: AOKI YOSHITAKA 福井大学, 学術研究院医学系部門(附属病院部), 講師 (30273006)
• Co-Investigator(Kenkyū-buntansha): 横山 修 福井大学, 学術研究院医学系部門, 教授 (90242552) ; 日下 幸則 福井大学, 学術研究院医学系部門, 教授 (70135680) ; 松田 陽介 福井大学, 学術研究院医学系部門(附属病院部), 講師 (90345687) ; 岡田 昌裕 福井大学, 学術研究院医学系部門, 特別研究員 (40572441) ; 松本 智恵子 福井大学, 学術研究院教育・人文社会系部門(教員養成), 准教授 (80377043)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 下部尿路症状 / 糖尿病 / 高血圧 / 肥満 / 縦断研究 / 夜間頻尿 / 住民健診 / メタボリック症候群 / 生活習慣病 / 尿意切迫感 / 夜間多尿

Outline of Final Research Achievements

We evaluated the natural history of nocturia and among Japanese men and women in a longitudinal study. Nocturia was defined as two or more voids per night. The present results showed fluctuations in nocturia during the 5-year period. These fluctuations might have been due to the multifactorial etiology of nocturia, including aging, lifestyle, obesity, hypertension and diabetes.
We also analyzed the relationship between overactive bladder (urgency) and age, gender, metabolic syndrome (MetS) among participants who had nocturia. The logistic regression modeling were used for statistical analyses. A significant association was found between nocturia with urgency and MetS. The age and sex-adjusted odds ratio (95%CI) was 1.49 (1.22-1.82). Our study confirmed that individuals who report nocturia with urgency are more at risk of MetS than those with nocturia without urgency. The combination of symptoms should prompt closer attention to cardiovascular health among primary care providers.

Academic Significance and Societal Importance of the Research Achievements

今回の解析により、夜間頻尿という症状は、単なる排尿の問題ではなく、そこにはメタボリック症候群と関連があることが明らかとなった。そして、夜間頻尿の変動は、関連疾患の変化に伴っている可能性があることが示唆され、今後の更なる検討が必要であると考えられた。
この結果から、夜間頻尿の診療にあたる泌尿器科医は、その症状の背景に内科疾患が存在しうることを意識する必要があるだろう。またさらには、メタボリック症候群あるいは心血管系疾患を扱う実地臨床医においては、夜間頻尿をはじめとする排尿症状が、それらの発見のきっかけとなるマーカーになりうることを意識した診療が必要であることが示唆された。

Research Products

• [Int'l Joint Research] University of Tampere/University of Helsinki/Kuopio University Hospital(フィンランド)
• [Int'l Joint Research] McMaster University/University of Toronto(カナダ)
• [Int'l Joint Research] Imperial College(英国)
• [Int'l Joint Research] Comprehensive Cancer Organization(オランダ)
• [Int'l Joint Research] Birmingham Geriatric Research Center(米国)
• [Journal Article] An international survey on the use of thromboprophylaxis in urological surgery (2018)
  • Author(s): Violette P., Vernooij R., Aoki Y.、Agarwal A., Cartwright R., Arai Y., Tailly T., Novara G., Craigie S., Breau R., Sandset P.M., Guyatt G., Tikkinen K.
  • Journal Title: European Urology Supplements Volume: 17
  • DOI: 10.1016/s1569-9056(18)31927-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A RELATIONSHIP BETWEEN PRE-DIABETES AND OVERACTIVE BLADDER-ANALYSIS OF A HEALTH-SCREENING PROGRAM IN MEN AND WOMEN (2018)
  • Author(s): Aoki, Y., Okada, M., Ito, H., Kusaka, Y., Yokoyama, O
  • Journal Title: NEUROUROLOGY AND URODYNAMICS Volume: 37
  • Peer Reviewed
• [Journal Article] SERUM C-REACTIVE PROTEIN LEVEL IS NOT ASSOCIATED WITH THE PROSTATIC INFLAMMATION BUT OVERACTIVE DETRUSOR IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA (2018)
  • Author(s): Inamura, S; Ito, H; Tsutsumiuchi, M; Taga, M; Tsuchiyama, K; Matsuta, Y; Aoki, Y; Kobayashi, M; Yokoyama, O
  • Journal Title: NEUROUROLOGY AND URODYNAMICS Volume: 37
  • Peer Reviewed
• [Journal Article] Urinary incontinence in women. (2017)
  • Author(s): Aoki, Y., Brown, H. W., Brubaker, L., Cornu, J. N., Daly, J. O., & Cartwright, R.
  • Journal Title: Nature Reviews Disease Primer Volume: 3 Pages: 17042-17042
  • DOI: 10.1038/nrdp.2017.97
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 下部尿路症状とメタボリック症候群 (2017)
  • Author(s): 青木 芳隆, 岡田 昌裕, 横山 修
  • Journal Title: 泌尿器外科 Volume: 30 Pages: 143-147
• [Journal Article] 男性下部尿路症状とメタボリック症候群 (2017)
  • Author(s): 横山 修, 伊藤 秀明, 青木 芳隆, 松田 陽介, 福島 正人
  • Journal Title: 腎臓内科・泌尿器科 Volume: 5 Pages: 140-144
• [Journal Article] Long-Term Endoscopic Follow-Up of Patients with Chronic Radiation Proctopathy after Brachytherapy for Prostate Cancer (2016)
  • Author(s): M. Ohtani, H. Suto, T. Nosaka, Y. Saito, Y. Ozaki, R. Hayama, T. Naito, K. Takahashi, K. Ofuji, H. Matsuda, K. Hiramatsu, T. Nemoto, H. Shioura, H. Kimura, Y. Aoki, O. Yokoyama, Y. Nakamoto
  • Journal Title: Diagn. Ther. Endosc. Volume: 2016:1414090 Pages: 1414090-1414090
  • DOI: 10.1155/2016/1414090
  • Peer Reviewed / Open Access
• [Journal Article] Long-term impact of mode of delivery on stress urinary incontinence and urgency urinary incontinence: A systematic review and meta-analysis (2016)
  • Author(s): RM.Tähtinen, R.Cartwright, JF.Tsui, RL.Aaltonen, Y.Aoki, JL.Cárdenas, R.El Dib, KM.Joronen, S.Al Juaid, S.Kalantan, M.Kochana, M.Kopec, LC.Lopes, E.Mirza, SM.Oksjoki, JS.Pesonen, A.Valpas, L.Wang, Y.Zhang, D.Heels-Ansdell, GH.Guyatt, KA.Tikkinen
  • Journal Title: Eur Urol Volume: 70 Pages: 148-158
  • DOI: 10.1016/j.eururo.2016.01.037
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Incidence and remission of nocturia: A systematic review and meta-analysis (2016)
  • Author(s): JS.Pesonen, R.Cartwright, A.Mangera, H.Santti, TL.Griebling, AE.Pryalukhin, J.Riikonen, RM.Tähtinen, A.Agarwal, JF.Tsui, CP.Vaughan, AD.Markland, TM 2nd.Johnson, R.Fonsell-Annala, C.Khoo, TL.Tammela, Y.Aoki, A.Auvinen, D.Heels-Ansdell, GH.Guyatt, KA.Tikkinen
  • Journal Title: Eur Urol Volume: 70 Pages: 372-381
  • DOI: 10.1016/j.eururo.2016.02.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 前立腺肥大症とメタボリック症候群 (2016)
  • Author(s): 横山 修, 伊藤 秀明, 青木 芳隆, 松田 陽介, 山内 寛喜
  • Journal Title: Prostate Journal Volume: 3 Pages: 71-75
• [Journal Article] 排尿障害Update: 下部尿路症状の疫学－メタアナリシスによる新たな知見－ (2016)
  • Author(s): 青木 芳隆
  • Journal Title: Urology Today Volume: 23 Pages: 32-35
• [Presentation] A RELATIONSHIP BETWEEN PRE-DIABETES AND OVERACTIVE BLADDER-ANALYSIS OF A HEALTH-SCREENING PROGRAM IN MEN AND WOMEN (2018)
  • Author(s): Aoki, Y., Okada, M., Ito, H., Kusaka, Y., Yokoyama, O
  • Organizer: 国際禁制学会
  • Int'l Joint Research
• [Presentation] SERUM C-REACTIVE PROTEIN LEVEL IS NOT ASSOCIATED WITH THE PROSTATIC INFLAMMATION BUT OVERACTIVE DETRUSOR IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA (2018)
  • Author(s): Inamura, S; Ito, H; Tsutsumiuchi, M; Taga, M; Tsuchiyama, K; Matsuta, Y; Aoki, Y; Kobayashi, M; Yokoyama, O
  • Organizer: 国際禁制学会
  • Int'l Joint Research
• [Presentation] An international survey on the use of thromboprophylaxis in urological surgery (2018)
  • Author(s): Violette P., Vernooij R., Aoki Y.、Agarwal A., Cartwright R., Arai Y., Tailly T., Novara G., Craigie S., Breau R., Sandset P.M., Guyatt G., Tikkinen K.
  • Organizer: 欧州泌尿器科学会
  • Int'l Joint Research
• [Presentation] Is it always necessary to treat nocturia? Natural history of nocturia among men and women during the 5-year period. (2018)
  • Author(s): Aoki Y, Okada M, Matsuta Y, Ito H, Matsumoto C, Kusaka Y, Yokoyama O
  • Organizer: Too Much Medicine Paulo Foundation International Medical Symposium
  • Int'l Joint Research
• [Presentation] RELATIONSHIP BETWEEN OVERACTIVE BLADDER AND METABOLIC SYNDROME: A CROSS-SECTIONAL STUDY AMONG JAPANESE MEN AND WOMEN. (2017)
  • Author(s): Aoki, Y., Matsumoto, C., Matsuta, Y., Ito, H., Kusaka, Y., & Yokoyama, O.
  • Organizer: 米国泌尿器科学会
  • Int'l Joint Research
• [Presentation] OVERACTIVE BLADDER IS RELATED TO SEXUAL WELL-BEING IN JAPANESE WOMEN. (2017)
  • Author(s): Aoki, Y., Sasaki, K., Matsuta, Y., Ito, H., Matsumoto, C., Kusaka, Y., & Yokoyama, O.
  • Organizer: 米国泌尿器科学会
  • Int'l Joint Research
• [Presentation] Is Overactive Bladder Another Facet of the Metabolic Syndromeamong Japanese Men and Women? (2017)
  • Author(s): Yoshitaka Aoki, Masahiro Okada, Yosuke Matsuta, Hideaki Ito, Chieko Matsumoto, Yukinori Kusaka, Osamu Yokoyama
  • Organizer: 国際禁制学会
  • Int'l Joint Research
• [Presentation] Bidirectional relationship between nocturia and insomnia in a longitudinal study among japanese men and women (2016)
  • Author(s): Y.Aoki, M.Okada, S.Yokoi, Y.Matsuta, H.Ito, C.Matsumoto, Y.Kusaka, O.Yokoyama
  • Organizer: 第46回国際禁制学会年次総会（ICS2016 TOKYO）
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Int'l Joint Research
• [Book] はいせつケア・リハ (2018)
  • Author(s): 青木芳隆、青柳 澄、安西順子、石井洋介、大関美里、太田有美、小林篤史、小林貴代、小林晴名、浜田きよ子、藤井 里香、松下 太、宮崎詩子、森田 昌、山内なぎさ、山下和典
  • Total Pages: 256
  • Publisher: ｇｅｎｅ
  • ISBN: 4905241847
• [Book] みんなで取り組む排尿管理 チームづくりから実践指導例まで (2018)
  • Author(s): 鈴木基文（編）、青木芳隆（編）、ほか
  • Total Pages: 152
  • Publisher: 日本医療企画
  • ISBN: 4864397449
• [Remarks] The impact of nocturia on mortality: a SR and MA
  • URL: http://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42016051132
• [Remarks] CLUE Working Group
  • URL: http://clueworkinggroup.com/
• [Remarks] 福井大学研究者総覧
  • URL: http://t-profile.ad.u-fukui.ac.jp/search/index.html