Study on autophagy and tumor immunology by Interleukin 18 in CD8-positive T cells
| Project/Area Number |
16K11220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
Tsuzuki Kenzo 兵庫医科大学, 医学部, 准教授 (50441308)
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| Research Collaborator |
Hashimoto Kengo
Okazaki Ken
Oka Naoto
Nishikawa Hiroki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 免疫学 / IL-18 / 抗腫瘍活性 / 内視鏡下副鼻腔手術 / 慢性副鼻腔炎 / 好酸球性副鼻腔炎 / スコア化 / 鼻副鼻腔内反性乳頭腫 / 鼻症状 / quality of life / 嗅覚障害 / 鼻科学 / 内視鏡下鼻副鼻腔手術 |
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| Outline of Final Research Achievements |
Although there have been several reports that simultaneously stimulated natural killer cells (NK cells) with IL-12, 15, and 18, the cytotoxicity of NK cells by individual cytokine stimulation was unknown. This study demonstrated in more detail that NK cells show increased cytotoxic activity by IL-15 and 18 stimulation and decreased by IL-12. In the clinical research on inflammatory diseases, we proposed scoring systems that can predict the postoperative course from the pre- and intra-operative findings of chronic rhinosinusitis, and the usefulness were discussed.
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| Academic Significance and Societal Importance of the Research Achievements |
悪性腫瘍に対する免疫治療において、natural killer細胞（NK細胞）は重要な役割をもつことが報告されている。サイトカインによる刺激を受けたNK細胞のphenotypeの詳細な機能や分化条件について解明した。炎症疾患における研究では、慢性副鼻腔炎の術前、術中所見から、術後経過を推測しうる因子を解明できた。
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Report
(4 results)
Research Products
(39 results)
