Development of the next generation polymeric nano DDS for intractable head and neck cancer
Project/Area Number |
16K11226
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | The University of Tokyo |
Principal Investigator |
Matsumoto Yu 東京大学, 医学部附属病院, 助教 (80548553)
|
Research Collaborator |
Miyano Kazuki
Horacio Cabral
Inoue Yuta
Igarashi Kazunori
Toh Kazuko
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 生体イメージング / ナノテクノロジー / 頭頚部外科学 |
Outline of Final Research Achievements |
The study aims to incorporate multiple functions into the polymeric nano DDS. The intravital kinetics of the nano DDS were analyzed to optimize the molecular modification. The tongue carcinoma cells and oral carcinoma cells were used to analyze the antitumor activity of the nano DDS. The PEG length was determined as the molecular weight of 12000 according to the blood circulation assay. The tumor-targeting molecule was installed on the surface of nano DDS, and the linking ratio was optimized as 20%. IVIS imaging system and intravital confocal microscopy were used to analyze the intratumoral distribution of the nano DDS. Our results suggested that the installation of the cRGD peptide on the nano DDS promoted the targeting of tumor and metastatic lymph node, and improved antitumor efficacy and survival.
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Academic Significance and Societal Importance of the Research Achievements |
腫瘍組織の血管透過性に依存した「受動的ターゲティング」ナノDDSでは治療が難しいがんを克服したいと考えています。標的指向分子を搭載した次世代の高分子ナノDDSを開発しました。細胞実験や動物実験を行い、cRGDを搭載したナノDDSが腫瘍や転移性リンパ節に集積して治療効果を改善することを確認しました。今後も様々な分子修飾による作り込みと機能評価を行い、ナノDDSの開発を進めます。
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain.2018
Author(s)
Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka
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Journal Title
Nat. Commun.
Volume: 8
Pages: 1-001
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting.2017
Author(s)
Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka
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Journal Title
Biomaterials
Volume: 113
Pages: 253-265
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic vesicular nanoreactors with tumor-specific activation and self-destruction for synergistic tumor ablation.2017
Author(s)
J. Li, A. Dirisala, Z. Ge, Y. Wang, W. Yin, W. Ke, K. Toh, J. Xie, Y. Matsumoto, Y. Anraku, K. Osada, K. Kataoka
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Journal Title
Angew. Chem. Int. Ed.
Volume: 56
Pages: 14025-14030
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.2016
Author(s)
Anraku Y, Kishimura A, Kamiya M, Tanaka S, Nomoto T, Toh K, Matsumoto Y, Fukushima S, Sueyoshi D, Kano MR, Urano Y, Nishiyama N, Kataoka K.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 55
Pages: 560-5
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.2016
Author(s)
Kikuta S, Matsumoto Y, Kuboki A, Nakayama T, Asaka D, Otori N, Kojima H, Sakamoto T, Akinori K, Kanaya K, Ueha R, Kagoya R, Nishijima H, Toma-Hirano M, Kikkawa Y, Kondo K, Tsunoda K, Miyaji T, Yamaguchi T, Kataoka K, Mori K, Yamasoba T.
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Journal Title
Sci Rep.
Volume: 6
Pages: 35361-35361
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Enhanced Efficacy against Cervical Carcinomas through Polymeric Micelles Physically Incorporating the Proteasome Inhibitor MG132.2016
Author(s)
Matsumoto Y, Miyamoto Y, Cabral H, Matsumoto Y, Nagasaka K, Nakagawa S, Yano T, Maeda D, Oda K, Kawana K, Nishiyama N, Kataoka K, Fujii T
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Journal Title
Cancer Sci.
Volume: in press
Pages: 773-781
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery2016
Author(s)
Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto, Horacio Cabral, Yutaka Miura, R. James Christie, Naoki Yamada, Tadayoshi Ogura, Mitsunobu R. Kano, Yasuhiro Matsumura, Nobuhiro Nishiyama, Tatsuya Yamasoba, You Han Bae, Kazunori Kataoka
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Journal Title
Nat. Nanotechnol.
Volume: -
Pages: 533-538
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Systemic Delivery of Sirna by Actively Targeted Polyion Complex Micelles for Silencing the E6 and E7 Human Papillomavirus Oncogenes2016
Author(s)
Nishida H, Matsumoto Y, Kawana K, Christie RJ, Naito M, Kim BS, Toh K, Min HS, Yi Y, Matsumoto Y, Kim HJ, Miyata K, Taguchi A, Tomio K, Yamashita A, Inoue T, Nakamura H, Fujimoto A, Sato M, Yoshida M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Nishiyama N, Kataoka K, Osuga Y, Fujii T
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Journal Title
Journal of Controlled Release
Volume: in press
Pages: 29-37
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy2016
Author(s)
T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka
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Journal Title
Biomaterials Scinece
Volume: 印刷中
Pages: 826-38
DOI
Related Report
Peer Reviewed
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[Journal Article] Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles.2016
Author(s)
Y. Yi, H. -J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. -S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata, K. Kataoka
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Journal Title
Journal of Controlled Release
Volume: 244
Pages: 247-256
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Manipulation of Tumor Vascular Bursts2017
Author(s)
Matsumoto Y, Inoue Y, Toh K, Miyano K, Cabral H, Igarashi K, Iwasaki S, Yamasoba T, Kataoka K
Organizer
14th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery
Related Report
Int'l Joint Research / Invited
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