• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel translymphatic chemotherapy using anti-EGFR antibody for metastatic lymph nodes of head and neck cancer

Research Project

Project/Area Number 16K11247
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyorin University (2019)
Teikyo University (2016-2018)

Principal Investigator

YOKOYAMA JUNKICHI  杏林大学, 医学部, 非常勤講師 (60312584)

Co-Investigator(Kenkyū-buntansha) 長谷川 泰久  朝日大学, 歯学部, 教授 (10261207)
大峡 慎一  順天堂大学, 医学部, 准教授 (20549274)
小島 雅貴  順天堂大学, 医学部, 助手 (30760003)
鈴木 雅明  帝京大学, 医学部, 教授 (40261630)
杉本 晃  帝京大学, 医学部, 講師 (50436432)
石橋 謙一郎  愛知学院大学, 歯学部, 非常勤講師 (80714609)
福村 由紀  順天堂大学, 医学部, 准教授 (90407312)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsリンパ管化学療法 / センチネルリンパ節 / 低侵襲治療 / ドラッグデリバリーシステム / targeting Chemotherapy / 頭頸部癌 / 抗EGF抗体 / リンパ管の可視化 / lymphatic chemotherapy / センチネルリンパ節理論 / Drud delivery system / 抗EGFR抗体 / Targeting chemotherapy / ICG蛍光法 / アポトー シス / アポトーシス / Drug Delivery System / Targeting Chemotherapy / アポートシス / 癌 / 外科 / 免疫学 / 病理学 / 臨床
Outline of Final Research Achievements

Development of a novel translymphatic chemotherapy using anti-EGFR antibody for metastatic lymph nodes of head and neck cancer
Neck lymph node metastasis is the most significant prognostic factor of head and neck cancer. According to the Sentinel theory, metastatic lymph nodes are directly connected with primary tumors via lymphatic canals. Lymphatic chemotherapy is defined as chemotherapy using lymphatic canals between metastatic lymph nodes and primary tumors. As an ultimate cancer treatment which is both highly effective and noninvasive, the current study is to establish a novel lymphatic chemotherapy targeting metastatic lymph nodes in patients with head and neck cancer using anti-EGFR antibody combined with anti-cancer and fluorescence dye.ICG fluorescence imaging reveals the lymphatic vessels to metastatic lymph nodes.We evaluated the usefulness of lymphatic chemotherapy targeting neck metastases by measuring EGFR concentrations in metastatic lymph nodes and pathological effects.

Academic Significance and Societal Importance of the Research Achievements

頭頸部癌の予後の改善には最大の予後因子であるリンパ節制御が必要である。効果的なリンパ節制御は、センチネルリンパ節理論により原発巣に投与した抗EGFR抗体が能動的に転移癌に直接強固に結合するため、原発巣だけでなく転移リンパ節もリンパ管経由により制御できる画期的な治療法である。本法により術後の機能障害の回避だけでなく手術に費やされてきた多くの外科医や手術室スタッフ等の労力や人件費等を削減することによる医療経済効果が得られる。また、多くの手術が回避できれば、医療崩壊の防止と時間のゆとりにより安全な医療活動と研究活動の時間が持て、医学の発展に寄与する可能性が高い。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (54 results)

All 2020 2019 2018 2017 2016 2015

All Journal Article (37 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 36 results,  Open Access: 30 results,  Acknowledgement Compliant: 7 results) Presentation (16 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Prognostic value of lymph node density for major salivary gland carcinoma without clinical lymph node metastasis.2020

    • Author(s)
      Terada H, Suzuki H, Hanai N, Nishikawa D, Koide Y, Hasegawa Y
    • Journal Title

      Am J Otolaryngol.

      Volume: 41(1): Issue: 1 Pages: 102304-102304

    • DOI

      10.1016/j.amjoto.2019.102304

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment package time predicts cancer-specific survival and distant metastasis in laryngeal cancer.2019

    • Author(s)
      Suzuki H, Terada H, Hanai N, Nishikawa D, Koide Y, Beppu S, Kodaira T, Tachibana H, Koide Y, Tanaka H, Hasegawa Y.
    • Journal Title

      Oncol Lett

      Volume: 17 Pages: 1384-1390

    • DOI

      10.3892/ol.2018.9664

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1?ALK fusion: a case report2019

    • Author(s)
      Honda Kazunori、Kadowaki Shigenori、Kato Kyoko、Hanai Nobuhiro、Hasegawa Yasuhisa、Yatabe Yasushi、Muro Kei
    • Journal Title

      Investigational New Drugs

      Volume: in press Issue: 4 Pages: 791-795

    • DOI

      10.1007/s10637-019-00742-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelioid hemangioendothelioma of the parotid gland: a case report.2019

    • Author(s)
      Koide Y, Sasaki E, Masago K, Fujita S, Beppu S, Nishikawa D, Suzuki H, Hasegawa Y
    • Journal Title

      Int Cancer Conf J

      Volume: 8(1) Issue: 1 Pages: 39-42

    • DOI

      10.1007/s13691-018-0351-0

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2)2019

    • Author(s)
      Matsuzuka Takashi、Kiyota Naomi、Mizusawa Junki、Akimoto Tetsuo、Fujii Masato、Hasegawa Yasuhisa、Iwae Shigemichi、Monden Nobuya、Matsuura Kazuto、Onozawa Yusuke、Hayashi Ryuichi、Tahara Makoto、Japan Clinical Oncology Group(JCOG) Head and Neck Cancer Study Group
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Issue: 1 Pages: 37-41

    • DOI

      10.1093/jjco/hyy145

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient Epstein-Barr Virus Progeny Production Mediated by Cancer-Derived LMP1 and Virally-Encoded microRNAs.2019

    • Author(s)
      Misako Yajima, Mamiko Miyata, Kazufumi Ikuta, Yasuhisa Hasegawa, Chitose Oneyama, Teru Kanda
    • Journal Title

      Microorganisms

      Volume: 7 Issue: 5 Pages: 119-119

    • DOI

      10.3390/microorganisms7050119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real‐time indocyanine green fluorescence‐navigated sentinel node navigation surgery2019

    • Author(s)
      Araki Koji、Tomifuji Masayuki、Shiotani Akihiro、Hirano Shigeru、Yokoyama Junkichi、Tsukahara Kiyoaki、Homma Akihiro、Yoshimoto Seichi、Hasegawa Yasuhisa
    • Journal Title

      Head & Neck

      Volume: 42 Issue: 2 Pages: 254-261

    • DOI

      10.1002/hed.25993

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary Tumor Size Predicts Distant Metastasis of Mucosal Malignant Melanoma in Head and Neck.2018

    • Author(s)
      Suzuki H, Takano G, Hanai N, Nishikawa D, Koide Y, Beppu S, Hasegawa Y.
    • Journal Title

      Anticancer Res

      Volume: 34 Issue: 11 Pages: 6485-6490

    • DOI

      10.21873/anticanres.13012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage.2018

    • Author(s)
      Suzuki H, Koide Y, Hanai N, Nishikawa D, Beppu S, Mikami S, Hasegawa Y.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 42 Pages: 26670-26678

    • DOI

      10.18632/oncotarget.25453

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peak of Standardized Uptake Value in Oral Cancer Predicts Survival Adjusting for Pathological Stage.2018

    • Author(s)
      Suzuki H, Tamaki T, Nishio M, Beppu S, Mukoyama N, Hanai N, Nishikawa D, Koide Y, Hasegawa Y.
    • Journal Title

      In Vivo

      Volume: 32 Issue: 5 Pages: 1193-1198

    • DOI

      10.21873/invivo.11363

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pembrolizumab in Asia-Pacific patients with advanced head and neck squamous cell carcinoma: Analyses from KEYNOTE-0122018

    • Author(s)
      Tahara M, Muro K, Hasegawa Y, Chung HC, Lin CC, Keam B, Takahashi K, Cheng JD,
    • Journal Title

      Cancer Sci. 2018 ;109(3):

      Volume: 109 Issue: 3 Pages: 771-776

    • DOI

      10.1111/cas.13480

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Total lesion glycolysis on FDG-PET/CT before salvage surgery predicts survival in laryngeal or pharyngeal cancer.2018

    • Author(s)
      Suzuki H, Tamaki T, Nishio M, Nakata Y, Hanai N, Nishikawa D, Koide Y, Hasegawa Y
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 27 Pages: 19115-19122

    • DOI

      10.18632/oncotarget.24914

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation analysis of the EGFR pathway genes, EGFR, RAS, PIK3CA, BRAF, and AKT1, in salivary gland adenoid cystic carcinoma.2018

    • Author(s)
      Saida K, Murase T, Ito M, Fujii K, Takino H, Masaki A, Kawakita D, Ijichi K, Tada Y, Kusafuka K,Iida Y, Onitsuka T, Yatabe Y, Hanai N, Hasegawa Y
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 24 Pages: 17043-17055

    • DOI

      10.18632/oncotarget.24818

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective randomized investigation implementing immunonutritional therapy using a nutritional supplement with a high blend ratio of ω-3 fatty acids during the perioperative period for head and neck carcinomas.2018

    • Author(s)
      Hanai N, Terada H, Hirakawa H, Suzuki H, Nishikawa D, Beppu S, Hasegawa Y
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 48 Issue: 4 Pages: 356-361

    • DOI

      10.1093/jjco/hyy008

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II trial of combination treatment with paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CSPOR-HN02).2018

    • Author(s)
      ahara M, Kiyota N, Yokota T, Hasegawa Y, Muro K, Takahashi S, Onoe T, Homma A, Taguchi J, Suzuki M, Minato K, Yane K, Ueda S, Hara H, Saijo K, Yamanaka T
    • Journal Title

      Ann Oncol

      Volume: 29 Issue: 4 Pages: 1004-1009

    • DOI

      10.1093/annonc/mdy040

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers.2018

    • Author(s)
      Hasegawa Y, Goto M, Hanai N, Ozawa T, Hirakawa H.
    • Journal Title

      Mol Clin Oncol

      Volume: 8 Pages: 378-386

    • DOI

      10.3892/mco.2017.1521

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal protective effect of a hydration supplemented with magnesium in patients receiving cisplatin for head and neck cancer2018

    • Author(s)
      Kimura T, Ozawa T, Hanai N, Hirakawa H, Suzuki H, Hosoi H, Hasegawa Y
    • Journal Title

      J Otolaryngol Head Neck Surg. 2018 Feb 2;47(1):10.

      Volume: 47 Issue: 1 Pages: 10-10

    • DOI

      10.1186/s40463-018-0261-3

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Impact of Skeletal Muscle Depletion on Head and Neck Squamous Cell Carcinoma.2018

    • Author(s)
      Nishikawa D, Hanai N, Suzuki H, Koide Y, Beppu S, Hasegawa Y
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 80 Issue: 1 Pages: 1-9

    • DOI

      10.1159/000485515

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers.2018

    • Author(s)
      Hasegawa Y, Goto M, Hanai N, Ozawa T, Hirakawa H
    • Journal Title

      Mol Clin Oncol.

      Volume: 8 Pages: 378-386

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case-control study.2018

    • Author(s)
      Sawabe M, Ito H, Takahara T, Oze I, Kawakita D, Yatabe Y, Hasegawa Y
    • Journal Title

      Cancer.

      Volume: 124 Issue: 1 Pages: 118-124

    • DOI

      10.1002/cncr.30957

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of decannulation, oral intake recovery, overall survival and lung metastasis following oral malignant tumor resection and reconstruction.2017

    • Author(s)
      Suzuki H, Hyodo I, Hasegawa Y.
    • Journal Title

      Oncol Lett.

      Volume: 15(2) Pages: 2686-2694

    • DOI

      10.3892/ol.2017.7585

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparisons of the clinical outcomes of different postoperative radiation strategies for treatment of head and neck squamous cell carcinoma.2017

    • Author(s)
      Makita C, Kodaira T, Daimon T, Tachibana H, Tomita N, Koide Y, Koide Y, Fukuda Y, NishikawaD, Suzuki H, Hanai N, Hasegawa Y
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 47 Issue: 12 Pages: 1141-1150

    • DOI

      10.1093/jjco/hyx137

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic importance of pathological response to neoadjuvant chemotherapy followed by definitive surgery in advanced oral squamous cell carcinoma.2017

    • Author(s)
      Hirakawa H, Hanai N, Suzuki H, Nishikawa D, Matayoshi S, Hasegawa Y
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 47 Issue: 11 Pages: 1038-1046

    • DOI

      10.1093/jjco/hyx097

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical results of definitive chemoradiotherapy for cervical esophageal cancer: Comparison of failure pattern and toxicities between intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy.2017

    • Author(s)
      Ito M, Kodaira T, Tachibana H, Tomita N, Makita C, Koide Y, Kato D, Abe T, Muro K, Tajika M, Niwa Y, Hasegawa Y.
    • Journal Title

      Head Neck.

      Volume: 39 Issue: 12 Pages: 2406-2415

    • DOI

      10.1002/hed.24909

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A randomized, open-label, Phase III clinical trial of nivolumab vs. therapy of investigator's choice in recurrent squamous cell carcinoma of the head and neck: A subanalysis of Asian patients versus the global population in checkmate 141.2017

    • Author(s)
      Kiyota N, Hasegawa Y, Takahashi S, Yokota T, Yen CJ, Iwae S, Shimizu Y, Hong RL, Goto M, Kang JH,
    • Journal Title

      Oral Oncol.

      Volume: 73 Pages: 138-146

    • NAID

      120006377619

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Matched-pair analysis of patients with advanced hypopharyngeal cancer: surgery versus concomitant chemoradiotherapy.2017

    • Author(s)
      Iwae S, Fujii M, Hayashi R, Hasegawa Y, Fujii T, Okami K, Homma A, Onitsuka T,
    • Journal Title

      Int J Clin Oncol.

      Volume: 22 Issue: 6 Pages: 1001-1008

    • DOI

      10.1007/s10147-017-1151-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma.2017

    • Author(s)
      Nakata Y, Hanai N, Nishikawa D, Suzuki H, Koide Y, Fukuda Y, Nomura M, Kodaira T, Shimizu T, Hasegawa Y
    • Journal Title

      Int J Clin Oncol.

      Volume: 22 Issue: 6 Pages: 1034-1041

    • DOI

      10.1007/s10147-017-1149-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma.2017

    • Author(s)
      Fujii K, Murase T, Beppu S, Saida K, Takino H, Masaki A, Ijichi K, Kusafuka K, Iida Y, Onitsuka T, Yatabe Y, Hanai N, Hasegawa Y
    • Journal Title

      Histopathology

      Volume: 7 Issue: 5 Pages: 823-834

    • DOI

      10.1111/his.13281

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study.2017

    • Author(s)
      Suzuki H, Kato K, Nishio M, Tamaki T, Fujimoto Y, Hiramatsu M, Hanai N, Kodaira T, Itoh Y, Naganawa S, Sone M, Hasegawa Y
    • Journal Title

      Ann Nucl Med

      Volume: 31 Issue: 7 Pages: 514-520

    • DOI

      10.1007/s12149-017-1176-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Cancer-Testis Antigens in Salivary Gland Carcinomas with Reference to MAGE-A and NY-ESO-1 Expression in Adenoid Cystic Carcinoma.2017

    • Author(s)
      Beppu S, Ito Y, Fujii K, Saida K, Takino T, Masaki A, Murase T, Kusafuka K, Iida Y, Onitsuka T, Yatabe Y, Hanai N, Hasegawa Y, Ijichi K, Murakami S, Inagaki H.
    • Journal Title

      Histopathology.

      Volume: 印刷中 Issue: 2 Pages: 305-315

    • DOI

      10.1111/his.13226

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complication and surgical site infection for salvage surgery in head and neck cancer after chemoradiotherapy and bioradiotherapy2017

    • Author(s)
      Hidenori Suzuki, Nobuhiro Hanai, Daisuke Nishikawa, Yujiro Fukuda, Yasuhisa Hasegawa
    • Journal Title

      Auris Nasus Larynx

      Volume: 印刷中 Issue: 5 Pages: 596-601

    • DOI

      10.1016/j.anl.2016.11.009

    • NAID

      130006647019

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heterogeneous impact of alcohol consumption according to treatment method on survival in head and neck cancer: A prospective study.2017

    • Author(s)
      Sawabe M, Ito H, Oze I, Hosono S, Kawakita D, Tanaka H, Hasegawa Y, Murakami S, Matsuo K.
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 1 Pages: 91-100

    • DOI

      10.1111/cas.13115

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sentinel node biopsy for oral cancer: A prospective multicenter Phase II trial.2017

    • Author(s)
      Miura K, Hirakawa H, Uemura H, Yoshimoto S, Shiotani A, Sugasawa M, Homma A, Yokoyama J
    • Journal Title

      Auris Nasus Larynx

      Volume: 44 Issue: 3 Pages: 319-326

    • DOI

      10.1016/j.anl.2016.07.008

    • NAID

      130006307989

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of Endoscopic Indocyanine Green Fluorescence Imaging on Superselective Intra-arterial Chemotherapy for Recurrent Cancer of the Skull Base2016

    • Author(s)
      J YOKOYAMA, K ISHIBASHI, H SHIRAMIZU, S OHBA
    • Journal Title

      ANTICANCER RESEARCH

      Volume: 36 Pages: 3419-3424

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Successful application of intra-arterial chemotherapy for advanced lacrimal sac carcinoma: a report of two cases2016

    • Author(s)
      R Hibiya, S Ohba, M Fujimaki, M Kojima, J Yokoyama, K Ikeda
    • Journal Title

      Otorhinolaryngol Head Neck Surg

      Volume: 2 Issue: 5 Pages: 128-130

    • DOI

      10.15761/ohns.1000132

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of Near-infrared Indocyanine green fluorescent image on minimally invasive treatments for head and neck cancer.2016

    • Author(s)
      J YOKOYAMA, K ISHIBASHI
    • Journal Title

      JJ Otolaryn.

      Volume: 2 Pages: 031-033

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma2015

    • Author(s)
      2: Wakisaka N, Hasegawa Y, Yoshimoto S, Miura K, Shiotani A, Yokoyama J, Sugasawa M, Moriyama-Kita M, Endo K, Yoshizaki T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 12 Pages: e0144056-e0144056

    • DOI

      10.1371/journal.pone.0144056

    • NAID

      120005743890

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 口腔進行癌に対する集学的治療2019

    • Author(s)
      大峡慎一、横山純吉、藤巻充寿、小島雅貴、松本文彦、池田勝久
    • Organizer
      日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院における再発・転移頭頸部癌に対するNivolumab療法の検討2019

    • Author(s)
      小島雅貴 大峡慎一 松本文彦 藤巻充寿 池田勝久
    • Organizer
      日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 咽頭後リンパ節転移に対する経口的手術2019

    • Author(s)
      大峡慎一 松本文彦 小島雅貴 藤巻充寿 池田勝久
    • Organizer
      日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 上顎洞に発生した基底細胞腺癌の1例2019

    • Author(s)
      小島雅貴 肥後隆三郎 池田勝久
    • Organizer
      日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頭頚部癌に対する集学的集学的治療とNivolumabの現在の位置付け2018

    • Author(s)
      横山純吉
    • Organizer
      オプジーボ頭頚部癌東海Seminar in Tokai
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] センチネルリンパ節理論による口腔癌の微小転移の検出とリンパ管化学療法2018

    • Author(s)
      横山純吉
    • Organizer
      お茶の水癌アカデミア
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 安全で効果的なPTEGの使用法の工夫2018

    • Author(s)
      横山純吉
    • Organizer
      PTEG研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口腔癌におけるICG蛍光法を用いたセンチネルリンパ節生検術の有用性の検討2018

    • Author(s)
      横山純吉、長谷川泰久、菅澤正、塩谷彰浩、大狭慎一、村上善子、甲能直幸
    • Organizer
      Sentinel Node Navigation Surgery
    • Related Report
      2018 Research-status Report
  • [Presentation] Feasibility study of ICG fluorescence-navigated sentinel node biopsy in head and neck cancer2018

    • Author(s)
      S Ohba, Y Hasegawa, J Yokoyama, M Sugasawa, A Shiotani, Y Murakami, N Kohno
    • Organizer
      International Sentinel Node Society Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Attempting to Define Sentinel Node Micrometastasis in Oral Squamous Cell Carcinoma2018

    • Author(s)
      T Matsuzuka, H Uemura, S Yoshimoto, K Miura, A Shiotani, M Sugasawa, A Homma, J Yokoyama, K Tsukahara
    • Organizer
      International Sentinel Node Society Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 進行声門癌に対する超選択的動注療法後再発症例の検討2017

    • Author(s)
      大峡慎一、藤巻充寿、小島雅貴、 横山純吉、池田勝久
    • Organizer
      日本頭頸部外科学会
    • Place of Presentation
      東京
    • Year and Date
      2017-02-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 気管孔閉鎖の嚥下機能に関する検討2017

    • Author(s)
      横山純吉、大狭慎一
    • Organizer
      日本頭頸部癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] エンドGIA自動吻合器を用いた誤嚥防止術の検討2017

    • Author(s)
      横山純吉
    • Organizer
      日本喉頭科学会
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] 進行声門癌に対する超選択的動注療法後再発症例の検討2017

    • Author(s)
      大峡慎一、藤巻充寿、小島雅貴 横山純吉
    • Organizer
      日本頭頸部外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭頚部癌に対する集学的集学的治療とNivolumabの現在の位置付け2017

    • Author(s)
      横山純吉
    • Organizer
      頭頚部癌東海Seminar in Tokai
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 頭頸部進行癌に超選択的動注療法にICG蛍光法の有用性の検討2016

    • Author(s)
      横山純吉、石橋謙一朗、大峡慎一
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Book] Video Atlas of Intraoperative Applications of Near Infrared Fluorescence Imaging2020

    • Author(s)
      Junkichi Yokoyama Shinich Ohba
    • Publisher
      Springer
    • ISBN
      9783030380922
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi