| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Reduced glutathione (GSH) is the most prevalent and most important intracellular thiol-disulfide redox buffer in mammalian cells. GSH plays a major role as antioxidants that function through a variety of mechanisms such as metal chelators and radical quenchers. We investigated the effect of arsenic and silver ions on the viability, alkaline phosphatase (ALP) activity and morphology of pulpal-like cells and to evaluate the influence of application of GSH) on those ions-induced cytotoxicity. The findings of this study suggest that those ions can severely disturb the viability, mineralization-ability and morphology of the pulpal-like cells while controlled concentrations of GSH mitigated those damage.
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