| Project/Area Number |
16K11631
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthodontics/ Dental materials science and
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | Nano-Hydroxyapatite / 生体微量金属 / 酸化マグネシウム / I型コラーゲン / 表面性状改善 / Ⅰ型コラーゲン / 酸化亜鉛 / 骨新生 / 親水処理 / 骨補填材 / ハイドロキシアパタイト / コラーゲン / 骨芽細胞 / 細胞培養 / 人工骨 / 骨増生 / 親水性 |
|---|
| Outline of Final Research Achievements |
In the verification of calcification by the alkaline phosphatase activity of MgO-containing Nano-Hydroxyapatite/Collagen, the material containing MgO showed higher stainability than the control. However, no significant difference was observed in the other bone differentiation markers compared with the control. From the results of animal experiments, it was suggested that MgO-containing n-HAP / Col may be significantly promote osteogenesis. However, since the bone maturity was insufficient, it was considered that the differentiation promoting effect was small.
At present, the surface properties of the Mg-containing n-HAP / Col treated by atmospheric pressure plasma are improved, and additional experiments of additional animal experiments have been conducted.
|
| Academic Significance and Societal Importance of the Research Achievements |
今回の研究結果より、Mg含有n-HAP / Colが人間の骨欠損で早期に骨新生する可能性が示唆された。今回使用している材料が、全て安価に入手することが可能であり、かつ生体親和性が高く毒性を持たない材料なために、人体での臨床研究へのハードルが高くないと考えられ、早期に臨床研究に移行できる可能性を含んでいる。また、今回研究中ではあるが、大気圧プラズマ処理によるリン酸カルシウム、および生体微量金属の表面改善の可能性も確認中であり、これらも現在利用可能な人工骨補填材に応用可能と考えている。これらの結果により、今回の研究結果は、社会的意義が高いものと考えらえる。
|
