Involvement of inferior alveolar nerve ischemia in neuropathic pain - experimental study by MRA and NIRS -

• Project/Area Number: 16K11745
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: KURATA Shigenobu 新潟大学, 医歯学系, 助教 (20464018)
• Co-Investigator(Kenkyū-buntansha): 山村 健介 新潟大学, 医歯学系, 教授 (90272822) ; 照光 真 北海道医療大学, 歯学部, 教授 (60401767) ; 瀬尾 憲司 新潟大学, 医歯学系, 教授 (40242440) ; 西山 秀昌 新潟大学, 医歯学系, 准教授 (60243250)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経障害性疼痛 / 神経虚血 / 下歯槽神経血管束 / MRA / MRI / 下歯槽神経 / NIRS

Outline of Final Research Achievements

In order to clarify the relationship between neuropathic pain in the inferior alveolar nerve and neural ischemia, we investigated it using magnetic resonance angiography (MRA) by a 1.5 Tesla MRI system. As a result of imaging the inferior alveolar neurovascular bundle using various MRA imaging methods, some imaging methods were able to be visualized well, but some imaging methods were difficult to visualize. In order to better visualize the fine structure of the inferior alveolar neurovascular bundle, further studies using MRI devices and coils with higher resolution are needed.

Academic Significance and Societal Importance of the Research Achievements

MRAの手法を用いることによってヒトで非侵襲的に下歯槽神経血管束を描出できる可能性が示唆された。そして、下歯槽神経損傷による神経障害性疼痛と神経虚血との関連を検証できる基盤ができつつあると考えられた。今後これらの手法を用いて患者群で神経虚血が検証されたならば、ヒトの三叉神経領域での神経障害性疼痛の新たな病態像を示すものとなり、新たな診断基準や治療戦略の基盤となり得る。

Research Products

• [Journal Article] High-contrast-resolution imaging of posttraumatic mandibular nerve by 3DAC-PROPELLER MRI: correlation with the severity of sensory disturbance. (2017)
  • Author(s): Terumitsu M, Matsuzawa H, Seo K, Watanabe M, Kurata S, Suda, A, Nakada T
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Volume: 印刷中 Pages: 85-94
  • DOI: 10.1016/j.oooo.2017.02.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 頚部郭清術後に生じた舌の慢性疼痛に対して生体内神経再生治療の適応を検討した1症例 (2016)
  • Author(s): 倉田行伸、照光 真、須田有希子、田中 裕、弦巻 立、金丸博子、吉川博之、佐藤由美子、平原三貴子、山田友里恵、瀬尾憲司
  • Organizer: 日本歯科麻酔学会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-10-28