Novel physiological role in secreted protein by psycho-social stress

• Project/Area Number: 16K13030
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: SHIUCHI Tetsuya 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (70372729)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心理社会的ストレス / エネルギー代謝 / 行動 / ストレス / 代謝 / サイトカイン / アドレナリン受容体 / 臓器連関

Outline of Final Research Achievements

I examined the physiological mechanism of secreted protein by psycho-social stress in mice. Male C57BL/6J mice given by social defeat stress showed social avoidance behavior with increase plasma level of protein "F", which was an important cytokine for energy expenditure. Exhaustive analysis revealed that mRNA expression of "F" was increased in liver, and that beta-adrenaline blocker inhibited protein "F" secretion under the stress. These results suggest that psycho-social stress secreted protein "F" from liver by sympathetic nerve activation or adrenaline in mice.

Research Products

• [Journal Article] Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. (2018)
  • Author(s): Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
  • Journal Title: Cell Rep. Volume: 22 Issue: 3 Pages: 706-721
  • DOI: 10.1016/j.celrep.2017.11.102
  • NAID: 120007001417
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance (2017)
  • Author(s): Chikahisa Sachiko、Harada Saki、Shimizu Noriyuki、Shiuchi Tetsuya、Otsuka Airi、Nishino Seiji、Sei Hiroyoshi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 13640-13640
  • DOI: 10.1038/s41598-017-14162-w
  • NAID: 120006535032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK. (2017)
  • Author(s): Shiuchi T, Toda C, Okamoto S, Coutinho EA, Saito K, Ezaki O, Minokoshi Y
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 15141-15141
  • DOI: 10.1038/s41598-017-15548-6
  • NAID: 120006535053
  • Peer Reviewed / Open Access
• [Journal Article] Intracerebroventricular injection of ghrelin decreases wheel running activity in rats. (2016)
  • Author(s): Miyatake Y, Shiuchi T, Mawatari K, Toda S, Taniguchi Y, Futami A, Sato F, Kuroda M, Sebe M, Tsutsumi R, Harada N, Minokoshi Y, Kitamura T, Gotoh K, Ueno M, Nakaya Y, Sakaue H.
  • Journal Title: Peptide Volume: 87 Pages: 12-19
  • DOI: 10.1016/j.peptides.2016.11.005
  • Peer Reviewed / Open Access
• [Journal Article] Late feeding in the active period decreases slow-wave activity. (2016)
  • Author(s): Oura K, Otsuka A, Shiuchi T, Chikahisa S, Shimizu N, Sei H
  • Journal Title: Life Science Volume: 160 Pages: 18-26
  • DOI: 10.1016/j.lfs.2016.07.005
  • Peer Reviewed
• [Presentation] 末梢―中枢連関を利用した運動モチベーションの制御 (2017)
  • Author(s): 志内哲也
  • Organizer: 第72回日本体力医学会
  • Invited
• [Presentation] 生体外からの刺激に対する動的恒常性維持機構と生体リズムとの連関 (2017)
  • Author(s): 志内哲也
  • Organizer: 第25回日本運動生理学会
  • Invited
• [Presentation] 摂食リズムによるエネルギー代謝と高次脳機能の変容 (2017)
  • Author(s): 志内哲也
  • Organizer: 第137回日本薬学会
  • Invited
• [Presentation] 末梢シグナル分子を介した運動モチベーション活性化への挑戦 (2017)
  • Author(s): 志内哲也
  • Organizer: 生理研研究会
  • Invited
• [Presentation] Alteration of behavior in offspring born from mother lived in the different feeding rhythm during pregnancy (2017)
  • Author(s): Tetsuya Shiuchi, Noriyuki Shimizu, Otsuka Airi, Sachiko Chikahisa and Hiroyoshi Sei
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan
• [Presentation] Restricted high fat diet can improve social avoidance induced by social-defeat stress as same as ad libitum high fat feeding (2016)
  • Author(s): Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Hiryoshi Sei
  • Organizer: Neuroscience 2016
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Restricted high-fat diet is enough to improve social avoidance induced by social-defeat stress (2016)
  • Author(s): Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Hiroyoshi Sei
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Pacifico Yokohama (Kanagawa, Yokohama)
  • Year and Date: 2016-07-20