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African killifish discloses Parkinson-like phenotypes during aging.

Research Project

Project/Area Number 16K14597
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionNiigata University

Principal Investigator

Matsui Hideaki  新潟大学, 研究推進機構, 准教授 (60710853)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsパーキンソン病 / アフリカメダカ / 神経科学
Outline of Final Research Achievements

Short-lived african killifish disclosed Parkinson-like phenotypes during aging. By utilizing this fish, we showed that propagation of alpha-synuclein of this fish. Dissection of the nervous system or depletion of alpha-synuclein ameliorated Parkinson-like neurodegeneration in this fish.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] An optimized method for counting dopaminergic neurons in zebrafish2017

    • Author(s)
      Matsui Hideaki、Sugie Atsushi
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0184363-e0184363

    • DOI

      10.1371/journal.pone.0184363

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Cerebrospinal fluid injection into adult zebrafish for disease research2017

    • Author(s)
      Matsui Hideaki、Matsui Noriko
    • Journal Title

      J Neural Transm

      Volume: 124 Issue: 12 Pages: 1627-1633

    • DOI

      10.1007/s00702-017-1787-7

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Parkinson’s disease pathogenesis from the viewpoint of small fish models2017

    • Author(s)
      Matsui Hideaki、Takahashi Ryosuke
    • Journal Title

      J Neural Transm

      Volume: 125 Issue: 1 Pages: 25-33

    • DOI

      10.1007/s00702-017-1772-1

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dopamine system, cerebellum, and nucleus ruber in fish and mammals2017

    • Author(s)
      Matsui Hideaki
    • Journal Title

      Dev Growth Differ

      Volume: 59 Issue: 4 Pages: 219-227

    • DOI

      10.1111/dgd.12357

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The Use of Fish Models to Study Human Neurological Disorders2017

    • Author(s)
      Hideaki Matsui
    • Journal Title

      Neuroscience Research

      Volume: 16 Pages: 1-7

    • DOI

      10.1016/j.neures.2017.02.004

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 生命科学を開く新しい実験動物モデル-11. 超短命脊椎動物アフリカメダカ2017

    • Author(s)
      Hideaki Matsui
    • Journal Title

      生体の科学

      Volume: 68 Pages: 80-84

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 魚のドパミン神経とパーキンソン病2017

    • Author(s)
      Hideaki Matsui
    • Organizer
      第6回生理研霊長研脳研合同シンポジウム
    • Place of Presentation
      新潟大学脳研究所統合脳機能研究センター
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Annual killifish, Nothobranchius furzeri, discloses Parkinson's disease phenotypes.2017

    • Author(s)
      Hideaki Matsui
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Annual Killifish, Nothobranchius furzeri, Suffers From Parkinson’s Disease.2017

    • Author(s)
      Hideaki Matsui
    • Organizer
      International Meeting on Non-Mammalian Models in Biomedical Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小型魚類で明らかにする神経病態2016

    • Author(s)
      Hideaki Matsui
    • Organizer
      第46回新潟神経学夏期セミナー
    • Place of Presentation
      新潟大学脳研究所統合脳機能研究センター
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 小型魚類を用いた神経疾患研究2016

    • Author(s)
      Hideaki Matsui
    • Organizer
      第57回神経学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Teleost fish models of Parkinson’s disease2016

    • Author(s)
      Hideaki Matsui
    • Organizer
      Symposium: Basal Ganglia in Health and Disease (Satellite Symposium of Neuroscience 2016)
    • Place of Presentation
      PACIFICO Yokohama
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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