African killifish discloses Parkinson-like phenotypes during aging.

• Project/Area Number: 16K14597
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Niigata University
• Principal Investigator: Matsui Hideaki 新潟大学, 研究推進機構, 准教授 (60710853)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: パーキンソン病 / アフリカメダカ / 神経科学

Outline of Final Research Achievements

Short-lived african killifish disclosed Parkinson-like phenotypes during aging. By utilizing this fish, we showed that propagation of alpha-synuclein of this fish. Dissection of the nervous system or depletion of alpha-synuclein ameliorated Parkinson-like neurodegeneration in this fish.

Research Products

• [Journal Article] Parkinson’s disease pathogenesis from the viewpoint of small fish models (2018)
  • Author(s): Matsui Hideaki、Takahashi Ryosuke
  • Journal Title: Journal of Neural Transmission Volume: 125 Pages: 25-33
  • DOI: 10.1007/s00702-017-1772-1
• [Journal Article] An optimized method for counting dopaminergic neurons in zebrafish (2017)
  • Author(s): Matsui Hideaki、Sugie Atsushi
  • Journal Title: PLoS One Volume: 12
  • DOI: 10.1371/journal.pone.0184363
• [Journal Article] Cerebrospinal fluid injection into adult zebrafish for disease research (2017)
  • Author(s): Matsui Hideaki、Matsui Noriko
  • Journal Title: J Neural Transm Volume: 124 Pages: 1627-1633
  • DOI: 10.1007/s00702-017-1787-7
• [Journal Article] Dopamine system, cerebellum, and nucleus ruber in fish and mammals (2017)
  • Author(s): Matsui Hideaki
  • Journal Title: Dev Growth Differ Volume: 59 Pages: 219-227
  • DOI: 10.1111/dgd.12357
• [Journal Article] The Use of Fish Models to Study Human Neurological Disorders (2017)
  • Author(s): Hideaki Matsui
  • Journal Title: Neurosci Res Volume: 16 Pages: 1-7
  • DOI: 10.1016/j.neures.2017.02.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 生命科学を開く新しい実験動物モデル-11. 超短命脊椎動物アフリカメダカ (2017)
  • Author(s): Hideaki Matsui
  • Journal Title: 生体の科学 Volume: 68 Pages: 80-84
  • Acknowledgement Compliant
• [Presentation] 魚のドパミン神経とパーキンソン病 (2017)
  • Author(s): Hideaki Matsui
  • Organizer: 第6回生理研霊長研脳研合同シンポジウム
  • Place of Presentation: 新潟大学脳研究所統合脳機能研究センター
  • Year and Date: 2017-03-09
  • Invited
• [Presentation] Annual killifish, Nothobranchius furzeri, discloses Parkinson's disease phenotypes. (2017)
  • Author(s): Hideaki Matsui
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] An Annual Killifish, Nothobranchius furzeri, Suffers From Parkinson’s Disease. (2017)
  • Author(s): Hideaki Matsui
  • Organizer: International Meeting on Non-Mammalian Models in Biomedical Research
  • Int'l Joint Research / Invited
• [Presentation] 小型魚類で明らかにする神経病態 (2016)
  • Author(s): Hideaki Matsui
  • Organizer: 第46回新潟神経学夏期セミナー
  • Place of Presentation: 新潟大学脳研究所統合脳機能研究センター
  • Year and Date: 2016-07-28
  • Invited
• [Presentation] 小型魚類を用いた神経疾患研究 (2016)
  • Author(s): Hideaki Matsui
  • Organizer: 第57回神経学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2016-05-18
  • Invited
• [Presentation] Teleost fish models of Parkinson’s disease (2016)
  • Author(s): Hideaki Matsui
  • Organizer: Symposium: Basal Ganglia in Health and Disease (Satellite Symposium of Neuroscience 2016)
  • Place of Presentation: PACIFICO Yokohama
  • Invited