Cellular basis of tumor microenvironment in tumor-bearing mice

• Project/Area Number: 16K14608
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Osaka University
• Principal Investigator: Yasunaga Kei-ichiro 大阪大学, 医学系研究科, 助教 (20534572)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腫瘍微小環境 / 癌 / 抗腫瘍免疫 / 血管 / 制御性Ｔ細胞 / 組織透明化 / 不活化センダイウイルス粒子 / HVJ-E / 制御性T細胞

Outline of Final Research Achievements

In this study, we utilized imaging techniques and tissue clearing methods to address cellular interaction between cancer cells, immune cells, and blood vessels in the tumor microenvironment, and found the possibility that HVJ-E treatment affected the distribution of tumor vasculatures in mouse tumors.

Research Products

• [Remarks] 研究室ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/gts/