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Functional analysis of LSR and development of innovative therapy for ovarian cancer stem cells.

Research Project

Project/Area Number 16K14637
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionKochi University

Principal Investigator

NAKA TETSUJI  高知大学, 教育研究部医療学系臨床医学部門, 教授 (30303936)

Co-Investigator(Renkei-kenkyūsha) FUJIMOTO MINORU  高知大学, 教育研究部・医療学系臨床医学部門, 准教授 (00379190)
SERADA SATOSHI  高知大学, 医学部附属病院, 特任准教授 (50463302)
YOSHINO KIYOSHI  大阪大学, 医学系研究科, 准教授 (90362730)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords卵巣癌 / 癌幹細胞 / LSR / 抗体療法
Outline of Final Research Achievements

Principal investigator’s (PI) group identified Lipolysis-stimulated lipoprotein receptor (LSR) as a new therapeutic target of ovarian cancer. LSR is one of the receptor of lipoprotein and located at cell surface, however, the function of LSR in cancer is still unclear. In this research, PI’s group demonstrated that in low glucose environment, LSR promoted lipoprotein uptake and contributed to cell proliferation/viability in vitro. Moreover, PI’s group also demonstrated that their newly developed anti-LSR monoclonal antibody inhibited these processes and showed anti-tumor effect in vitro and in vivo. In addition, the expression of CD44 which is one of the cancer stem cell related marker was decreased after administration of anti-LSR monoclonal antibody in vivo, suggesting that anti-LSR monoclonal antibody showed anti-tumor effect against cancer stem cell.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake2018

    • Author(s)
      Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T
    • Journal Title

      Cancer Res

      Volume: 78 Issue: 2 Pages: 516-27

    • DOI

      10.1158/0008-5472.can-17-0910

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] LSR promotes ovarian cancer cell growth following the activation of β-oxidation and its antibody inhibits lipid catabolism. ポスター発表(英語)2017

    • Author(s)
      Hiramatsu K, Serada S, Enomoto T, Yokoyama T, Takahashi Y, Fujimoto M, Yoshino K, Kimura T, Naka T.
    • Organizer
      AACR Annual Meeting 2017 in Washington, D.C
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] LSR promotes beta-oxidation via lipid uptake and subsequent tumor growth in ovarian cancer.口頭発表(英語)2017

    • Author(s)
      Hiramatsu K, Serada S, Fujimoto M, Matsuzaki S, Ueda Y, Yoshino K, Kimura T, Naka T.
    • Organizer
      第76回日本癌学会学術総会 パシフィコ横浜
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-12-27  

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