Generation of complex and elaborate patterns with invariant cell lineages during trunk oikoplastic epidermis development of appendicularians
Project/Area Number |
16K14735
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
小沼 健 大阪大学, 理学研究科, 助教 (30632103)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | オタマボヤ / 尾虫類 / Oikopleura / 表皮 / パターン形成 / 細胞系譜 / ライブイメージング / 幹細胞分裂 / 胚発生 / 形態形成 |
Outline of Final Research Achievements |
Mechanisms for morphogenetic processes that generate complex patterns in a reproducible manner remain elusive. The trunk epidermis of appendicularians, called the oikoplastic epithelium (OE), has elaborate cellular arrangements showing a complex pattern. The OE is characterized by invariant number, size, and shape of the monolayer epithelial cells. First, we subdivided the OE and defined several domains by cellular resolution, and systematically gave names to the constituent cells. Time-lapse imaging of the epidermal cells revealed region-specific pattern formation processes. Regulation of orientation, timing, and the number of rounds of cell divisions, but not cell death and migration, was a critical mechanism for determination of final cell arrangement and size. These detailed descriptions of OE patterning processes provide basic and essential information in the generation of elaborate and intricate but stereotyped cellular patterns.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets2017
Author(s)
Brozovic Matija、Dantec Christelle、,,,,,,, Nishida Hiroki、,,,,,,, Lemaire Patrick
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Journal Title
Nucleic Acids Res.
Volume: 46
Issue: D1
Pages: D718-D725
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Redundant mechanisms are involved in suppression of default cell fates during embryonic mesenchyme and notochord induction in ascidians.2016
Author(s)
Kodama, H., Miyata, Y., Kuwajima, M., Izuchi, R., Kobayashi, A., Gyoja, F., Onuma, T.A., Kumano, G., Nishida, H.
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Journal Title
Dev. Biol.
Volume: 416
Issue: 1
Pages: 162-172
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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