Comprehensive study on individual genetic variability in dietary effects using genome-wide association studies
| Project/Area Number |
16K14920
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kato Hisanori 東京大学, 総括プロジェクト機構, 特任教授 (40211164)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ゲノム / 遺伝子多型 / ゲノムワイド関連解析 / コーヒー / 魚食 / アレルギー / 食習慣 / 一塩基多型 / 個人差 / 摂取量 / インターネット / ニュートリゲノミクス / 健康補助食品 / ゲノムワイド相関解析 |
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| Outline of Final Research Achievements |
For the prevention of diseases through personalized nutrition, it is necessary to elucidate the genetic background of individual variability in the effects of foods. Nevertheless, large-scale studies conducted in the Japanese population are limited.
To reveal the association between SNPs and food factors, we performed genome-wide association studies (GWAS) on dietary habits using the large-scale SNP database of the Japanese population and an internet-based questionnaire survey. We identified SNPs significantly associated with four selected dietary habits, demonstrating the effectiveness of the internet-based genomic cohort studies. We provide the first evidence that fish intake frequency had a significant interaction with genotypes. Also, we found that in Japanese population the SNP different from European population affects dietary habits.
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Report
(3 results)
Research Products
(2 results)
