Studies on the pathological mechanisms of feline morbillivirus associated with chronic renal failure

• Project/Area Number: 16K15039
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Kyoto University
• Principal Investigator: Miyazawa Takayuki 京都大学, ウイルス・再生医科学研究所, 准教授 (80282705)
• Research Collaborator: SAKAGUCHI Shoichi ; KOIDE Rie ; TANIKAGA Takamasa ; IRIE Takashi ; FURUYA Tetsuya ; Mizutani Tetsuya ; Sindo Keiko ; Noda Takeshi ; Kuwahara Chieko ; Sakai Sachi ; Asai Ken-ichi ; Kawakami Kazuo
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: ネコモルビリウイルス / 猫 / 腎不全 / 免疫応答 / 慢性腎不全 / 自然免疫応答 / 欠陥干渉ウイルス粒子 / リバースジェネティックス / ネコ / ウイルス

Outline of Final Research Achievements

There have been few studies focusing on the relationships between cat nephritis and virus infections. However, feline morbillivirus (FeMV) associated with tubulointerstitial nephritis was discovered in Hong Kong in 2012. FeMV is classified as a member of Family Paramyxoviridae, Genus Morbillivirus, which is detected in urine and feces of FeMV-infected cats. Since FeMV was detected in cats in various Asian, European and American countries, it is considered that the virus is prevalent all over the world. On the other hand, the pathobiological mechanisms of this virus is still unknown. Therefore, in this study, we focused on the immune responses of the hosts in FeMV-infected cats and studied the relationships between FeMV infection and viral nephritis in cats.

Research Products

• [Journal Article] ネコモルビリウイルスの発見と現状について (2016)
  • Author(s): 古谷哲也、森川茂、宮沢孝幸
  • Journal Title: ウイルス Volume: 66 Pages: 147-154
  • NAID: 130006183764
  • Peer Reviewed / Open Access
• [Presentation] Epidemiologic survey of the feline paramyxovirus infection in Japan. (2018)
  • Author(s): Shoichi Sakaguchi, Rie Koide, So Nakagawa, Takayuki Miyazawa, Tetsuya Mizutani
  • Organizer: 12th China-Japan International Conference of Virology
• [Presentation] ベトナムの猫におけるネコモルビリウイルスの遡及血清調査 (2017)
  • Author(s): 小出りえ、坂口翔一、桑原千恵子、酒井沙知、浅井健一、川上和夫、宮沢孝幸
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] コモルビリウイルス持続感染細胞の性状および免疫応答の解析 (2017)
  • Author(s): 坂口翔一、小出りえ、神道慶子、野田岳志、水谷哲也、宮沢孝幸
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] Persistent feline morbillivirus infection in CRFK cells. (2017)
  • Author(s): Sakaguchi, S., Koide, R., Shindo, K., Noda, T., Mizutani, T., Miyazawa, T.
  • Organizer: 17th International Congress of Virology
• [Presentation] 猫の新興ウイルス感染症：慢性腎不全と関連するモルビリウイルス (2016)
  • Author(s): 宮沢孝幸
  • Organizer: 第37回動物臨床医学年次大会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] ネコモルビリウイルスの交差中和試験による血清学的比較 (2016)
  • Author(s): 小出りえ、坂口翔一、桑原知恵子、酒井沙知、中川草、谷利爵公、浅井健一、川上和夫、宮沢孝幸
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 神奈川県藤沢市
  • Year and Date: 2016-09-06
• [Presentation] ネコモルビリウイルス感染によるインターフェロン誘導遺伝子の発現 (2016)
  • Author(s): 坂口翔一、小出りえ、谷利爵公、入江崇、宮沢孝幸
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 神奈川県藤沢市
  • Year and Date: 2016-09-06