Analysis of mechanism of a novel cancersuressor derived from microorganism

• Project/Area Number: 16K15130
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines
• Research Institution: University of Tsukuba
• Principal Investigator: KUWAYAMA Hidekazu 筑波大学, 生命環境系, 准教授 (40397659)
• Co-Investigator(Renkei-kenkyūsha): MAEDA Yasuo 東北大学, 生命科学研究科, 名誉教授 (50025417) ; MAYANAGI Taira 岩手医科大学, 医学部, 講師 (20432544) ; CHIDA Junji 徳島大学, 疾患酵素学研究センター, 助教 (20437651)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ガン抑制因子 / 細胞性粘菌 / ガン抑制遺伝子 / 微生物由来ガン抑制因子

Outline of Final Research Achievements

Since 1981, cancer is the top cause of death in developed countries. In Japan, about thirty percent of the overall population die from cancer. We isolated a protein factor, DdMRP4, which suppresses the growth of cancer. In this study, we aim at reveal the molecular mechanism.
First of all, we succeeded the isolation of four protein coding genes which interact with DdMRP4. Furthermore, by the molecular genetic analyses, we found their functions are related to apoptosis and they are involved in the functions of development and cell differentiation in the model organism, Dictyostelium discoideum.

Research Products

• [Remarks] 桑山研究室のHP
  • URL: http://www.biol.tsukuba.ac.jp/~hidekuwayama/