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A novel role of adhesion-GPCR in synaptic functions and motor learning.

Research Project

Project/Area Number 16K15183
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKeio University

Principal Investigator

Kakegawa Wataru  慶應義塾大学, 医学部(信濃町), 准教授 (70383718)

Co-Investigator(Renkei-kenkyūsha) Yuzaki Michisuke  慶應義塾大学, 医学部, 教授 (40365226)
Miura Eriko  慶應義塾大学, 医学部, 研究員 (10571169)
Motohashi Junko  慶應義塾大学, 医学部, 研究員 (10407083)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞接着 / Gタンパク質共役型受容体 / シナプス / 記憶・学習 / Gタンパク質共役型受容体 / シグナル伝達 / 神経科学
Outline of Final Research Achievements

Recently, adhesion-type G protein-coupled receptors (ADGRs) have been intensively studied as molecules which regulate synapse integrity and learning & memory in the CNS. ADGR has a unique structure which contains an extracellular N-terminal domain with various types of functional domains, a seven-transmembrane region and an intracellular domain interacting with several signal molecules including G proteins. Despite its unique structure, the mechanisms by which ADGR behaves at synapses have remained unclear. In this study, we demonstrated that a brain-specific angiogenesis inhibitor 3 (BAI3), an ADGR member abundantly expressed at the synapses between climbing fiber (CF) and Purkinje cell in the cerebellum, plays crucial roles in synapse morphology, synaptic plasticity and cerebellar motor learning.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 Other

All Int'l Joint Research (5 results) Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] University of Oxford/University of Cambridge(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] DZNE(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Montreal Clinical Research Institute(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Oxford/University of Cambridge(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Vanderbilt University(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] 特集―スクラップ&ビルドで発達する脳神経回路と高次脳機能:スクラップ&ビルドによる小脳神経回路の動的制御.2018

    • Author(s)
      掛川渉, 柚﨑通介
    • Journal Title

      実験医学 (羊土社)

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 記憶・学習の分子機構-そのときシナプスでは何が起きているのか?2018

    • Author(s)
      掛川渉, 柚﨑通介
    • Journal Title

      BRAIN and NERVE-神経研究の進歩 (医学書院社)

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脳神経機能における素過程・構造をコントロールする分子群-17章 中枢神経系における分泌型シナプス形成因子.2018

    • Author(s)
      松田恵子, 掛川渉, 柚﨑通介
    • Journal Title

      脳の分子論 (東京化学同人社)

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Chemical labelling for visualizing native AMPA receptors in live neurons.2017

    • Author(s)
      Wakayama, S., Kiyonaka, S., Arai, I., Kakegawa, W., Matsuda, S., Ibata, K., Nemoto, Y.L., Kusumi, A., Yuzaki, M., Hamachi, I.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 14850-14850

    • DOI

      10.1038/ncomms14850

    • NAID

      120006600363

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特集―ニューロリハビリテーションの進歩:中枢神経の可塑性とは.2017

    • Author(s)
      河野まや, 掛川渉, 柚﨑通介
    • Journal Title

      Clinical Neuroscience (中外医学社)

      Volume: 5 Pages: 523-527

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Structural basis for integration of GluD receptors within synaptic organizer complexes.2016

    • Author(s)
      Elegheert, J., Kakegawa, W., Clay, E. J., Shanks, N., Behiels, E., Matsuda, K., Kohda, K., Miura, E., Rossmann, M., Mitakidis, N., Motohashi, J., Chang, T. V., Siebold, C., Greger, H. I., Nakagawa, T., K., Yuzaki, M., Aricescu, R.A.
    • Journal Title

      Science

      Volume: 353 Issue: 6296 Pages: 295-299

    • DOI

      10.1126/science.aae0104

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Current Topics:シナプスに架かる記憶への架け橋:Neurexin-Cbln1-GluD2三者複合体構造.2016

    • Author(s)
      掛川 渉, 柚﨑通介
    • Journal Title

      実験医学 (羊土社)

      Volume: 34 Pages: 3181-3184

    • Related Report
      2016 Research-status Report
  • [Journal Article] Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins2016

    • Author(s)
      Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.
    • Journal Title

      Neuron

      Volume: 90 Issue: 4 Pages: 752

    • DOI

      10.1016/j.neuron.2016.04.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 「補体ファミリー分子」とシナプス形成・維持.2016

    • Author(s)
      掛川 渉, 松田恵子, 柚﨑通介
    • Journal Title

      Annual Review神経2016 (中外医学社)

      Volume: - Pages: 35-43

    • Related Report
      2016 Research-status Report
  • [Presentation] A novel D-serine signaling which underlies synaptic plasticity and motor learning in the cerebellum.2017

    • Author(s)
      Kakegawa, W., Yuzaki, M.
    • Organizer
      第39回 日本生物学的精神医学会 (札幌)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Synergistic action of two different GluD2 ligands on D-serine signaling in the cerebellum.2017

    • Author(s)
      Kakegawa, W.
    • Organizer
      The 3rd International Conference of D-Amino Acid Research (Italy)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シナプス分子群がもたらす運動記憶ダイナミズムの解明2016

    • Author(s)
      掛川 渉
    • Organizer
      次世代脳プロジェクト・若手シンポジウム
    • Place of Presentation
      一橋講堂 (東京都千代田区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] D-Amino Acids: Physiology, Metabolism, and Application2016

    • Author(s)
      Kakegawa, W., Yuzaki, M.
    • Total Pages
      16
    • Publisher
      Springer Books
    • Related Report
      2016 Research-status Report
  • [Book] Essentials of cerebellum and cerebellar disorders2016

    • Author(s)
      Kohda, K., Kakegawa, W., Yuzaki, M.
    • Total Pages
      6
    • Publisher
      Springer Books
    • Related Report
      2016 Research-status Report
  • [Remarks] 慶應義塾大学医学部生理学教室 (柚﨑通介研究室)

    • URL

      http://www.yuzaki-lab.org/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-06-16  

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