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Innate immune defense of intestinal mucosa regulated by memory T cells in a gastrointestinal nematode infection model

Research Project

Project/Area Number 16K15269
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Parasitology (including sanitary zoology)
Research InstitutionJikei University School of Medicine

Principal Investigator

ISHIWATA KENJI  東京慈恵会医科大学, 医学部, 准教授 (00241307)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords粘膜免疫 / 再感染防御 / 寄生虫感染 / 免疫記憶 / 粘膜バリアー / 消化管寄生線虫 / Heligmosomoides / 自然免疫 / 腸管粘膜 / 腸管寄生線虫 / 寄生虫学 / 免疫学 / 腸管寄生虫
Outline of Final Research Achievements

Our preliminary results suggested that memory T cells maintain long-term innate immune defense on intestinal mucosa against reinfection of infective larvae of mice gastrointestinal nematode, Heligmosomoides polygyrus, which penetrate mucosal tissue. Detailed examination revealed that the larvae penetrated mucosal tissue where they reached and re-penetrated upper part 1/6 of the small intestine 1-2 days later. Results suggest that the transient penetration seems to evoke acquired immune response to block larval re-penetration. Our findings point out two significant information, 1) prevision of the known life cycle of H. polygyrus, and 2) a new protective mechanism exist as penetration blockade of the larvae against the reinfection as well as adult worm expulsion from the lumen. This protective pathway would be applicable to the vaccine strategies for intestinal infections caused by virus or bacteria.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

Research Products

(7 results)

All 2018 2017 Other

All Presentation (5 results) Remarks (2 results)

  • [Presentation] A new immune-mediated protecitve mechanism against reinfection of Heligmosomoides polygyrus clarified by re-examining its infection mode2018

    • Author(s)
      石渡賢治
    • Organizer
      第87回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Heligmosomoides polygyrusの再感染防御における腸管粘膜バリアー2017

    • Author(s)
      石渡賢治
    • Organizer
      第11回蠕虫研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] T cell-dependent long-lasting blockade of mucosal penetration by infective larvae of a murine gastrointestinal nematode2017

    • Author(s)
      石渡賢治
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Another protective immune response against Heligmosomoides polygyrus reinfection revealed by reviewing of the infection dynamics2017

    • Author(s)
      石渡賢治
    • Organizer
      第11回寄生虫感染免疫研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 消化管寄生線虫の再感染防御における腸管粘膜バリアー2017

    • Author(s)
      石渡賢治
    • Organizer
      第86回日本寄生虫学会大会
    • Place of Presentation
      北海道大学 学術交流会館、北海道札幌市
    • Related Report
      2016 Research-status Report
  • [Remarks] 東京慈恵会医科大学 熱帯医学講座

    • URL

      http://jikei-tropmed.jp

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京慈恵会医科大学 熱帯医学講座

    • URL

      http://www.jikei-tropmed.jp/index.html

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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