• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanism of IL-17 production in anti-fungal immunity

Research Project

Project/Area Number 16K15271
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionChiba University

Principal Investigator

SAIJO Shinobu  千葉大学, 真菌医学研究センター, 准教授 (60396877)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords感染免疫 / サイトカイン / 真菌感染 / 真菌 / 感染症 / 免疫 / 遺伝子改変マウス / 細菌
Outline of Final Research Achievements

Fungi are ubiquitous in environments and host immune systems are constantly engaged with these eukaryotic pathogens. We have reported taht C-type lectin receptors (CLRs) that expressed in myeloid cells play a central role in host defenses against fungal infections by coordinating immune systems. Cytokine production is one of the most characteristic and crucial responses in anti-fungal immunity led by ligand ligation of CLRs. However, in vivo mechanisms of this process has not been fully explained . In this study, we describe the molecular mechanisms of cytokine production in anti-fungal activities by the host immune systems.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 Other

All Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] C-type lectin receptors in anti-fungal immunity.2017

    • Author(s)
      Shiokawa M., Yamasaki S., Saijo S.,
    • Journal Title

      Curr Opin Microbiol.

      Volume: 40 Pages: 123-130

    • DOI

      10.1016/j.mib.2017.11.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LC3-associated phagocytosis is required for dendritic cell inflammatory cytokine response to gut commensal yeast Saccharomyces cerevisiae.2017

    • Author(s)
      Lamprinaki, D., Beasy, G., Zhekova, A., Wittmann, A., James, S., Dicks, J., Iwakura, Y., Saijo, S., Wang, X., Chow, C. W., Roberts, I., Korcsmaros, T., Mayer, U., Wileman, T., and Kawasaki, N.
    • Journal Title

      Front. Immunol.

      Volume: 8 Pages: 1397-1397

    • DOI

      10.3389/fimmu.2017.01397

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.2017

    • Author(s)
      Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.
    • Journal Title

      J Immunol.

      Volume: 198 Issue: 1 Pages: 61-70

    • DOI

      10.4049/jimmunol.1502393

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae2016

    • Author(s)
      Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
    • Journal Title

      BMC Immunol

      Volume: 17 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12865-015-0139-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis2016

    • Author(s)
      Fabio Yoshikawa, Rikio Yabe, Yoichiro Iwakura, Sandro Rogerio de Almeida, Shinobu Saijo
    • Journal Title

      Innate Immunity

      Volume: in press Issue: 5 Pages: 316-24

    • DOI

      10.1177/1753425916645392

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.2016

    • Author(s)
      Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.
    • Journal Title

      J Immunol.

      Volume: 197 Issue: 1 Pages: 278-87

    • DOI

      10.4049/jimmunol.1502485

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016

    • Author(s)
      Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
    • Journal Title

      J Biol Chem.

      Volume: 291 Issue: 34 Pages: 17629-38

    • DOI

      10.1074/jbc.m116.741256

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.2016

    • Author(s)
      Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A.

      Volume: 113 Issue: 49 Pages: 14097-14102

    • DOI

      10.1073/pnas.1617903113

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis2015

    • Author(s)
      Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
    • Journal Title

      Inflamm Res

      Volume: 65 Issue: 3 Pages: 235

    • DOI

      10.1007/s00011-015-0910-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Roles of Dectin-1 and Dectin-2 in anti-fungal immunity2017

    • Author(s)
      Shinobu Saijo
    • Organizer
      International Cytokine and Interferon Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 真菌によるIL-17産生機構2016

    • Author(s)
      西城 忍
    • Organizer
      AMED-CREST若手研究会
    • Place of Presentation
      大阪アカデミア (大阪府大阪市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 真菌の細胞壁構成成分とC型レクチン受容体による認識2016

    • Author(s)
      西城 忍
    • Organizer
      第81回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      長崎大学良順会館 (長崎県長崎市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 千葉大学真菌医学研究センター 感染免疫分野・サイトカインプロジェクト

    • URL

      http://cytokine.pf.chiba-u.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 千葉大学真菌医学研究センター感染免疫分野

    • URL

      http://cytokine.pf.chiba-u.jp/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi