Molecular mechanism of IL-17 production in anti-fungal immunity
| Project/Area Number |
16K15271
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
SAIJO Shinobu 千葉大学, 真菌医学研究センター, 准教授 (60396877)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 感染免疫 / サイトカイン / 真菌感染 / 真菌 / 感染症 / 免疫 / 遺伝子改変マウス / 細菌 |
|---|
| Outline of Final Research Achievements |
Fungi are ubiquitous in environments and host immune systems are constantly engaged with these eukaryotic pathogens. We have reported taht C-type lectin receptors (CLRs) that expressed in myeloid cells play a central role in host defenses against fungal infections by coordinating immune systems. Cytokine production is one of the most characteristic and crucial responses in anti-fungal immunity led by ligand ligation of CLRs. However, in vivo mechanisms of this process has not been fully explained . In this study, we describe the molecular mechanisms of cytokine production in anti-fungal activities by the host immune systems.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae.2017
Author(s)
Lamprinaki, D., Beasy, G., Zhekova, A., Wittmann, A., James, S., Dicks, J., Iwakura, Y., Saijo, S., Wang, X., Chow, C. W., Roberts, I., Korcsmaros, T., Mayer, U., Wileman, T., and Kawasaki, N.
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Journal Title
Front Immunol.
Volume: 8
Pages: 1397-1397
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis.2016
Author(s)
Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
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Journal Title
Inflamm Res.
Volume: 65
Pages: 235-244
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae.2016
Author(s)
Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
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Journal Title
BMC Immunol.
Volume: 17
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016
Author(s)
Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
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Journal Title
J Biol Chem.
Volume: 291
Pages: 17629-17638
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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