Investigation of contribution of novel tight junction molecule at the two big central nervous system barriers and its usefulness as a therapeutic target for multiple sclerosis
| Project/Area Number |
16K15475
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
Uchida Yasuo 東北大学, 薬学研究科, 助教 (70583590)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIKAWA Masanori 東北大学, 大学院薬学研究科, 准教授 (00401810)
TERASAKI Tetsuya 東北大学, 大学院薬学研究科, 教授 (60155463)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Claudin-11 / 多発性硬化症 / 血液脳関門 / 血液脊髄関門 / 血液脳脊髄液関門 / 血液クモ膜関門 / 定量プロテオミクス / 密着結合 / 中枢関門 / Claudin11 |
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| Outline of Final Research Achievements |
Multiple sclerosis is a disorder that autoreactive lymphocytes invade into central nervous system (CNS) and destroy it. The inhibition of disruption of the CNS barriers (which allows the lymphocytes invade into the CNS) is an important therapeutic strategy. However, it remained to be elucidated for the molecular mechanism of CNS barrier breakdown. The present study was the first to clarify that “claudin-11” contributes to the tight junction formation of several CNS barriers and its down-regulation causes the breakdown of CNS barriers in multiple sclerosis.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Inner blood-retinal barrier dominantly expresses breast cancer resistance protein: Comparative quantitative targeted absolute proteomics (QTAP) study of CNS barriers in pig2017
Author(s)
Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S, Hosoya K, Urtti A, Terasaki T, Tachikawa M
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Journal Title
Mol Pharm
Volume: 14
Issue: 11
Pages: 3729-3738
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] 多発性硬化症における中枢関門の破綻への新規密着結合分子claudin-11 の寄与の解明2018
Author(s)
内田康雄, 住谷智仁, 立川正憲, 山川達也, 村田将, 八木悠太, 佐藤和貴, 伊藤克彰, 大槻純男, Pierre-Olivier Couraud, 鈴木貴, 寺崎哲也
Organizer
日本薬剤学会第33 年会
Related Report
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