• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of "disease control system" of adult still disease based on whole exon sequence

Research Project

Project/Area Number 16K15514
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionNagasaki University

Principal Investigator

KOGA Tomohiro  長崎大学, 医歯薬学総合研究科(医学系), 助教 (90537284)

Co-Investigator(Kenkyū-buntansha) 吉浦 孝一郎  長崎大学, 原爆後障害医療研究所, 教授 (00304931)
右田 清志  福島県立医科大学, 医学部, 教授 (60264214)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords成人発症スチル病 / IL-1β / IL-18 / 全エクソン解析 / 成人スチル病 / 前エクソン解析 / 血清バイオマーカー / ゲノム / 免疫学 / トランスレーショナルリサーチ
Outline of Final Research Achievements

The purpose of this study was to identify the disease susceptibility gene and analyze its function by analyzing whole exons using a next-generation sequencer for patients with ASD, and to clarify the pathophysiology of ASD and to develop a new therapeutic drug. The study was carried out as follows. The ASD network was constructed in cooperation with existing autoimmune disease workshop and West Kyushu autoimmune disease workshop.
Clinical information, genomic DNA, serum, blood plasma, and biopsy tissue were collected utilizing the specialist network described above. The obtained genomic DNA was analyzed in whole exon using the next generation sequencer by the cooperative research with Professor Koichiro Yoshiura of Human Genetics, Nagasaki University, and the candidate of disease susceptibility SNP was identified. Using serum samples with ASD and serum samples from patients with sepsis, a cytokine that discriminates between them was identified.

Academic Significance and Societal Importance of the Research Achievements

ASDは特異的な自己抗体等の血清バイオマーカーがなく、診断は除外診断である。また、重症例ではサイトカインストームによる血球貪食症候群や播種性血管内凝固症候群を引き起こし予後不良である。本研究成果は、血清バイオマーカーによるASDの層別化や敗血症との鑑別を試み、診断に有用なサイトカインの組み合わせを同定した。また、全エクソン解析において、疾患感受性SNPを同定した。現時点でこれらのSNPの病的意義は不明であり、今後の機能的解析が必要であるが、病態解明および新規治療法の開発のシーズとなる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] MicroRNA-204-3p inhibits lipopolysaccharide-induced cytokines in familial Mediterranean fever via the phosphoinositide 3-kinase γ pathway2017

    • Author(s)
      Koga Tomohiro,Migita Kiyoshi,Sato Tomohito,Sato Shuntaro,Umeda Masataka,Nonaka Fumiaki,Fukui Shoichi,Kawashiri Shin-ya,Iwamoto Naoki,Ichinose Kunihiro,Tamai Mami,Nakamura Hideki,Origuchi Tomoki,Ueki Yukitaka,Masumoto Junya,Agematsu Kazunaga,Yachie Akihiro,Yoshiura Koh-ichiro,Eguchi Katsumi,Kawakami Atsushi
    • Journal Title

      Rheumatology

      Volume: 57 Issue: 4 Pages: 718-726

    • DOI

      10.1093/rheumatology/kex451

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Familial Mediterranean fever complicated with refractory asthma: Successful treatment with colchicine.2017

    • Author(s)
      Koga T, Fukushima C, Umeda M, Migita K, Kawakami A.
    • Journal Title

      Mod Rheumatol.

      Volume: 27 Issue: 1 Pages: 182-183

    • DOI

      10.3109/14397595.2016.1173000

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever.2016

    • Author(s)
      Koga T, Migita K, Sato S, Umeda M, Nonaka F, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura K, Eguchi K, Kawakami A.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95 Issue: 16 Pages: e3449-e3449

    • DOI

      10.1097/md.0000000000003449

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Serum fibroblast growth factor 2 is a useful biomarker to distinguish adult onset still disease from sepsis2018

    • Author(s)
      Tomohiro Koga, Remi Sumiyoshi, Shuntaro Sato, Kiyoshi Migita, Toshimasa Shimizu, Masataka Umeda, Fumiaki Nonaka, Shoichi Fukui, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Akihiro Yachie, Takahiro Maeda, Atsushi Kawakami
    • Organizer
      欧州リウマチ学会(EULAR 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] スティル病と敗血症との鑑別用バイオマーカー2018

    • Inventor(s)
      古賀智裕
    • Industrial Property Rights Holder
      長崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-083489
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi