| Project/Area Number |
16K15548
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 表皮 / 炎症 / ストレス / バリア / 皮膚炎 / 皮膚病態学 |
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| Outline of Final Research Achievements |
We performed transcriptome analysis of four animal models for atopic dermatitis and fond only one new gene X. We found that the expression levels of gene X and its translational products are increased also in other dermatitis animal models, and human atopic dermatitis and psoriasis. The expression levels of inflammatory mediators in X-transfected human keratinocytes are higher than those in keratinocytes transfected with control vectors. The gene ontology analysis of the results of their RNA-Seq analysis demonstrated that gene X is involved in cell adhesion and differentiation, lipid synthesis, mitochondria. These results suggested that gene X can be involved in the defense system of the skin, including inflammation, stress responses, and barrier.
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