Characteristics of brain auditory information processing and ADHD-like symptom.

• Project/Area Number: 16K15555
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: Kikuchi Mitsuru 金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
• Co-Investigator(Kenkyū-buntansha): 林 則夫 群馬県立県民健康科学大学, 診療放射線学部, 准教授 (50648459)
• Research Collaborator: Yoshimura Yuko ; Hasegawa Chiaki ; Takahashi Tetsuya
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 注意欠陥多動性障害 / 脳磁図 / 幼児 / 聴覚誘発反応 / 同調性 / 脳機能 / 脳磁図計 / 聴覚

Outline of Final Research Achievements

The aim of this research is to investigate a novel sprout model that "atypicality of auditory information processing affects development". We researched on children with autism with ADHD symptoms. The synchronicity of the auditory evoked responses (P1m) in left and right hemispheres induced by speech stimulation was measured with an child-sized MEG system. We investigated the relationship between this brain functional synchronicity and the behavioral ability to be kept still. In children who cannot stay still, it was found that the synchronicity of the P1m in left and right hemispheres are low. This study revealed that the characteristics of auditory information processing are related to ADHD-like symptoms.

Research Products

• [Int'l Joint Research] モントリオール大学(カナダ)
• [Journal Article] Altered human voice processing in the frontal cortex and a developmental language delay in 3- to 5-year-old children with autism spectrum disorder (2017)
  • Author(s): Yoshimura Yuko、Kikuchi Mitsuru、Hayashi Norio、Hiraishi Hirotoshi、Hasegawa Chiaki、Takahashi Tetsuya、Oi Manabu、Remijn Gerard B.、Ikeda Takashi、Saito Daisuke N.、Kumazaki Hirokazu、Minabe Yoshio
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 17116-17116
  • DOI: 10.1038/s41598-017-17058-x
  • Peer Reviewed / Open Access
• [Journal Article] Band-specific atypical functional connectivity pattern in childhood autism spectrum disorder. (2017)
  • Author(s): Takahashi T, Yamanishi T, Nobukawa S, Kasakawa S, Yoshimura Y, Hiraishi H, Hasegawa C, Ikeda T, Hirosawa T, Munesue T, Higashida H, Minabe Y, Kikuchi M.
  • Journal Title: Clin Neurophysiol. Volume: 128 Issue: 8 Pages: 45-50
  • DOI: 10.1016/j.clinph.2017.05.010
  • Peer Reviewed
• [Journal Article] A Near-Infrared Spectroscopy Study on Cortical Hemodynamic Responses to Normal and Whispered Speech in 3- to 7-Year-Old Children. (2017)
  • Author(s): Remijn GB, Kikuchi M, Yoshimura Y, Shitamichi K, Ueno S, Tsubokawa T, Kojima H, Higashida H, Minabe Y.
  • Journal Title: J Speech Lang Hear Res. Volume: 1 Issue: 2 Pages: 465-470
  • DOI: 10.1044/2016_jslhr-h-15-0435
  • Peer Reviewed / Open Access
• [Journal Article] Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording (2016)
  • Author(s): Hasegawa C, Ikeda T, Yoshimura Y, Hiraishi H, Takahashi T, Furutani N, Hayashi N, Minabe Y, Hirata M, Asada M, Kikuchi M
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 34977-34977
  • DOI: 10.1038/srep34977
  • Peer Reviewed / Open Access
• [Journal Article] The Contribution of Increased Gamma Band Connectivity to Visual Non-Verbal Reasoning in Autistic Children: A MEG Study. (2016)
  • Author(s): Takesaki N, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Kaneda R, Nakatani H, Takahashi T, Mottron L, Minabe Y.
  • Journal Title: PLoS One. Volume: 15 Issue: 9 Pages: e0163133-e0163133
  • DOI: 10.1371/journal.pone.0163133
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder. (2016)
  • Author(s): Yoshimura, Y., Kikuchi, M., Hiraishi, H., Hasegawa, C., Takahashi, T., Remijn, G.B., Oi, M., Munesue, T., Higashida, H., & Minabe, Y.
  • Journal Title: NeuroImage: Clinical Volume: 12 Pages: 300-305
  • DOI: 10.1016/j.nicl.2016.07.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism. (2016)
  • Author(s): Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
  • Journal Title: PLoS One Volume: 13 Issue: 4 Pages: 0153077-0153077
  • DOI: 10.1371/journal.pone.0153077
  • Peer Reviewed / Open Access
• [Presentation] Atypical development of the central auditory system in young children with Autism spectrum disorder. (2017)
  • Author(s): Mitsuru Kikuchi, Yoshio Minabe
  • Organizer: CCD-KITMEGWorkshop
  • Int'l Joint Research / Invited
• [Presentation] Development of the central auditory system in typically developing young children and children with Autism spectrum disorder. (2017)
  • Author(s): Mitsuru Kikuchi, Yuko Yoshimura, Yoshio Minabe
  • Organizer: Biomagnetic Sendai ２０１７
  • Int'l Joint Research
• [Presentation] 幼児用MEGをもちいた幼児脳機能の分析 (2017)
  • Author(s): Mitsuru Kikuchi, Yoshio Minabe
  • Organizer: 5th INCF Japan Node International Workshop Advances in Neuroinformatics AINI 2017 New Approaches to Neuroinformatics Education
  • Int'l Joint Research / Invited
• [Presentation] 自閉症幼児期における最近のMEG研究 (2017)
  • Author(s): 菊知 充
  • Organizer: 第133回日本精神神経学会学術総会 教育講演
• [Presentation] 自閉スペクトラム症のMEG研究 (2017)
  • Author(s): 菊知 充
  • Organizer: 第２９回 小児脳機能研究会
• [Presentation] Atypical development of the auditory system in children with autism spectrum disorder (2016)
  • Author(s): Mitsuru Kikuchi，Yoshio Minabe
  • Organizer: The 20th International Conference on Biomagnetism (BIOMAG2016)
  • Place of Presentation: Seoul (Korea)
  • Int'l Joint Research
• [Presentation] Atypical brain activity in children with autism spectrum disorder (2016)
  • Author(s): Mitsuru Kikuchi
  • Organizer: The 3rd International Symposium on Cognitive Neuroscience Robotics: Toward Constructive Developmental Science
  • Place of Presentation: Osaka (Japan)
  • Int'l Joint Research
• [Presentation] Atypical development of the auditory system in children with autism: custom child-sized MEG studies (2016)
  • Author(s): 菊知 充
  • Organizer: 第55回日本生体医工学会大会 （富山国際会議場）
  • Place of Presentation: 富山国際会議場（富山市）
• [Presentation] 自閉症幼児期のMEG研究 (2016)
  • Author(s): 菊知 充 三邉義雄
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
• [Remarks] バンビプラン
  • URL: http://bambiplan.w3.kanazawa-u.ac.jp/
• [Remarks] 子どものこころの発達研究センター
  • URL: https://kodomokokoro.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学子どものこころの発達研究センター
  • URL: https://kodomokokoro.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学バンビプラン
  • URL: http://bambiplan.w3.kanazawa-u.ac.jp/