Acceleration and satisfaction of epigenetic drug discovery using profiling technology
| Project/Area Number |
16K15616
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
KOSEKI Jyun 大阪大学, 医学系研究科, 特任助教(常勤) (20616669)
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| Co-Investigator(Kenkyū-buntansha) |
今野 雅允 大阪大学, 医学系研究科, 寄附講座講師 (80618207)
西田 尚弘 大阪大学, 医学系研究科, 助教 (50588118)
川本 弘一 大阪大学, 医学部附属病院, その他 (30432470)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Hideshi 大阪大学, 大学院医学系研究科, 特任教授 (10280736)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / エピゲノム / 創薬 / インシリコスクリーニング |
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| Outline of Final Research Achievements |
It was very difficult in the past to screen inhibitors of JARID1B, one of epigenome regulatory factor. We have made it possible using our in silico screening technologies with large-scale computer. In silico screening has been already performed to pick up the candidate compounds from five million drug like compounds. Then, we selected first lead compounds from the picked up candidate compounds with chemical assay. We have investigated the in vitro anti-cancer effects of these lead compounds, and the after, investigated the in vivo anti-cancer effects for the part of them. We succeeded in establishing a pathway to show the synthetic evolution guidelines for lead compounds based on the functional information from these experimental results. According to this procedure, it is possible to design a more efficient drug structure.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Clinical significance of histone demethylase NO66 in invasive colorectal cancer.2017
Author(s)
Nishizawa, Y., Nishida, N., Konno, M., Kawamoto, K., Asai, A., Koseki, J., Takahashi, H., Haraguchi, N., Nishimura, J., Hata, T., Matsuda, C., Mizushima, T., Satoh, T., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Ann. Surg. Oncol.
Volume: 24
Pages: 841-849
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The importance of mitochondrial folate enzymes in human colorectal cancer.2017
Author(s)
Miyo, M., Konno, M., Colvin, S. H., Nishida, N., Koseki, J., Kawamoto, K., Tsunekuni, K., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Oncol. Rep.
Volume: 37
Pages: 417-425
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.2017
Author(s)
Haraguchi, N., Ohara, N., Koseki, J., Takahashi, H., Nishimura, J., Hata, T., Mizushima, T., Yamamoto, H., Ishii, H., Doki, Y., Mori, M.
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Journal Title
Mol. Clinic. Oncol.
Volume: 6
Pages: 130-137
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy.2016
Author(s)
Baek, SJ., Sato, K., Nishida, N., Koseki, J., Azuma, R., Kawamoto, K., Konno, M., Hayashi, K., Satoh, T., Doki, Y., Mori, M., Ishii, H., Ogawa, K.
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Journal Title
Oncol. Rep
Volume: 36
Pages: 2946-2950
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Oncometabolite D-2-hydroxyglurate directly induces epithelial-mesenchymal transition and is associated with distant metastasis in colorectal cancer.2016
Author(s)
Colvin, S. H., Nishida, N., Konno, M., Haraguchi, N., Takahashi, H., Nishimura, J., Hata, T., Kawamoto, K. Asai, A., Tsunekuni, K., Koseki, J., Mizushima, T., Satoh, T., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Sci. Rep.
Volume: 6
Pages: 36289-36289
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Trans-Omics Analysis Shows Novel Functional Change in the Ornithine Metabolic Pathway Between Cancer Stem Cells and Non-Cancer Stem Cells2016
Author(s)
Koseki, J., Matsui, H., Konno, M., Nishida, N., Kawamoto, K., Kano, Y., Asai, A., Doki, Y., Mori, M., Ishii, H.
Organizer
The 26th Hot Spring Harbor International Symposium
Place of Presentation
Kyushu University(福岡）
Year and Date
2016-11-02
Related Report
Int'l Joint Research / Invited
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[Presentation] Thermodynamic and molecular orbital analysis of the effects caused by incorporation of novel anti-tumor agent Trifluridine to DNA2016
Author(s)
Koseki, J., Tsunekuni, K., konno, M., Nishida, N., Kawamoto, K., Doki, Y., Mori, M., Ishii, H.
Organizer
AACR Annual Meeting 2016
Place of Presentation
Ernest N. Morial Convention Center(アメリカ）
Year and Date
2016-04-16
Related Report
Int'l Joint Research
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