Novel pancreatic cancer treatment combining immune suppression mechanism and autophagy induction virus therapy

• Project/Area Number: 16K15623
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Hiroki Yamaue 和歌山県立医科大学, 医学部, 教授 (20191190)
• Co-Investigator(Kenkyū-buntansha): 中森 幹人 和歌山県立医科大学, 医学部, 准教授 (10322372) ; 川井 学 和歌山県立医科大学, 医学部, 准教授 (40398459) ; 尾島 敏康 和歌山県立医科大学, 医学部, 講師 (60448785) ; 廣野 誠子 和歌山県立医科大学, 医学部, 講師 (60468288)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: iPS細胞 / 樹状細胞 / 膵癌 / WT1 / 癌ワクチン / 免疫遺伝子治療 / 免疫療法 / ウイルス療法 / 抗がんウイルス

Outline of Final Research Achievements

We investigated whether genetically modified human induced pluripotent stem cell (iPSC)-derived dendritic cells (hiPSDCs) expressing WT1 could induce WT1-specific cytotoxic T cells in pancreatic cancer patients. We differentiated hiPSDCs from iPSCs of three pancreatic cancer patients and transduced the WT1 cDNA into hiPSDCs. The surface marker expression, cytokine secretion and migratory capacity of hiPSDCs were equivalent in healthy donors. After three cycles of stimulation of autologous peripheral blood mononuclear cells by genetically modified hiPSDCs, cytotoxicity was assessed using 51Cr release assay. The cytotoxic T cells induced by hiPSDCs-WT1 exhibited WT1-specific cytotoxic activity against the target cells expressing WT1. Genetically modified iPSDCs expressing WT1 is a promising tool for clinical application on vaccine therapy against pancreatic cancer patients.

Academic Significance and Societal Importance of the Research Achievements

膵癌は5年生存率が10%以下と難治癌であることは周知の事実である．私達は，以前より膵癌に対する癌ワクチン療法の基礎研究を行ってきた．今回，膵癌患者においてiPS細胞由来樹状細胞を誘導し，WT1遺伝子を導入し，CTLを誘導した．CTLはWT1発現腫瘍細胞を特異的に攻撃することを確認した．現在臨床試験に向けてさらなる検討を行っている．本研究が臨床応用されれば，世界初のiPS細胞を用いた膵癌ワクチン療法となり，難治癌で苦しむ患者さんに希望を与えるとともに，現在停滞している日本の癌遺伝子免疫治療においてブレークスルーとなる．

Research Products

• [Journal Article] Robotic radical lymphadenectomy without touching the pancreas during gastrectomy for gastric cancer. (2019)
  • Author(s): Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Maruoka S, Yamaue H.
  • Journal Title: Medicine Volume: 98 Issue: 13 Pages: e15091-e15091
  • DOI: 10.1097/md.0000000000015091
  • Peer Reviewed / Open Access
• [Journal Article] Decreased serum carbohydrate antigen 19-9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients. (2019)
  • Author(s): Aoki S, Motoi F, Murakami Y, Sho M, Satoi S, Honda G, Uemura K, Okada KI, Matsumoto I, Nagai M, Yanagimoto H, Kurata M, Fukumoto T, Mizuma M, Yamaue H, Unno M; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
  • Journal Title: BMC Cancer. Volume: 19 Issue: 1 Pages: 252-252
  • DOI: 10.1186/s12885-019-5460-4
  • NAID: 120007127669
  • Peer Reviewed / Open Access
• [Journal Article] Triplet chemotherapy with docetaxel, cisplatin and S-1 for unresectable advanced squamous cell carcinoma of the esophagus: phase I/II trial results (2019)
  • Author(s): Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
  • Journal Title: Oncotarget Volume: 10 Issue: 8 Pages: 847-855
  • DOI: 10.18632/oncotarget.26614
  • Peer Reviewed / Open Access
• [Journal Article] Triangulating stapling vs functional end-to-end stapling for cervical esophagogastric anastomosis after esophagectomy for thoracic esophageal cancer: study protocol for a randomized controlled trial (2019)
  • Author(s): Tsuji T, Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
  • Journal Title: Trials Volume: 20 Issue: 1 Pages: 83-83
  • DOI: 10.1186/s13063-019-3201-2
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant Use of Indocyanine Green Fluorescence Imaging and Interventional Radiology for Detection of Liver Segments During Laparoscopic Anatomical Liver Resection: Pilot Feasibility Study. (2019)
  • Author(s): Ueno M, Hayami S, Sonomura T, Kawai M, Hirono S, Okada KI, Tanaka R, Yamaue H.
  • Journal Title: Surg Laparosc Endosc Percutan Tech. Volume: in press Issue: 4 Pages: 242-246
  • DOI: 10.1097/sle.0000000000000631
  • Peer Reviewed
• [Journal Article] Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis. (2019)
  • Author(s): Klompmaker S，Peters NA，van Hilst J，Bassi C， Boggi U， Yamaue H, Wolfgang CL, Hogg ME, Besselink MG; E-AHPBA DP-CAR study group.
  • Journal Title: Ann Surg Oncol. Volume: 26 Issue: 3 Pages: 772-781
  • DOI: 10.1245/s10434-018-07101-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery. (2019)
  • Author(s): Nagakawa Y, Sahara Y, Hosokawa Y, Murakami Y, Yamaue H, Satoi S, Unno M, Isaji S, Endo I, Sho M, Fujii T, Takishita C, Hijikata Y, Suzuki S, Kawachi S, Katsumata K, Ohta T, Nagakawa T, Tsuchida A.
  • Journal Title: Ann Surg Oncol. Volume: in press Issue: 6 Pages: 1629-1636
  • DOI: 10.1245/s10434-018-07131-8
  • Peer Reviewed
• [Journal Article] Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05). (2019)
  • Author(s): Motoi F, Kosuge T, Ueno H, Yamaue H, Satoi S, Sho M, Honda G, Matsumoto I, Wada K, Furuse J, Matsuyama Y, Unno M; Study Group of Preoperative Therapy for Pancreatic Cancer (Prep) and Japanese Study Group of Adjuvant Therapy for Pancreatic cancer (JSAP).
  • Journal Title: Jpn J Clin Oncol. Volume: 49 Issue: 2 Pages: 190-194
  • DOI: 10.1093/jjco/hyy190
  • Peer Reviewed
• [Journal Article] Robotic complete lymphadenectomy at the splenic hilum during total gastrectomy for advanced gastric cancer (with video). (2019)
  • Author(s): Ojima T, Hayata K, Yamaue H.
  • Journal Title: Journal of Visceral Surgery Volume: in press Issue: 2 Pages: 173-174
  • DOI: 10.1016/j.jviscsurg.2018.12.005
  • Peer Reviewed
• [Journal Article] Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment. (2019)
  • Author(s): Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
  • Journal Title: Cancer Immunology and Immunotheraoy Volume: 68 Issue: 2 Pages: 201-211
  • DOI: 10.1007/s00262-018-2263-4
  • Peer Reviewed
• [Journal Article] Sustained Elevation of Postoperative Serum Level of Carbohydrate Antigen 19-9 is High-Risk Stigmata for Primary Hepatic Recurrence in Patients with Curatively Resected Pancreatic Adenocarcinoma. (2019)
  • Author(s): Motoi F, Murakami Y, Okada KI, Matsumoto I, Uemura K, Satoi S, Sho M, Honda G, Fukumoto T, Yanagimoto H, Kinoshita S, Kurata M, Aoki S, Mizuma M, Yamaue H, Unno M; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
  • Journal Title: World J Surg. Volume: 43 Issue: 2 Pages: 634-641
  • DOI: 10.1007/s00268-018-4814-4
  • Peer Reviewed
• [Journal Article] Conversion Surgery for Gastric Cancer with Peritoneal Metastasis Based on the Diagnosis of Second-Look Staging Laparoscopy. (2019)
  • Author(s): Nakamura M, Ojima T, Nakamori M, Katsuda M, Tsuji T, Hayata K, Kato T, Yamaue H.
  • Journal Title: Journal of Gastrointestinal Surgery Volume: in prss Issue: 9 Pages: 1758-1766
  • DOI: 10.1007/s11605-018-3983-7
  • Peer Reviewed
• [Journal Article] Optimal Timing of Removal of Epidural and Urethral Catheters to Avoid Postoperative Urinary Retention Undergoing Abdominal Surgery. (2019)
  • Author(s): Hayami S, Ueno M, Kawai M, Kuriyama T, Kawamata T, Yamaue H.
  • Journal Title: Dig Surg. Volume: 36 Issue: 3 Pages: 261-265
  • DOI: 10.1159/000490199
  • Peer Reviewed
• [Journal Article] Modified Blumgart Mattress Suture Versus Conventional Interrupted Suture in Pancreaticojejunostomy During Pancreaticoduodenectomy: Randomized Controlled Trial. (2019)
  • Author(s): Hirono S, Kawai M, Okada KI, Miyazawa M, Kitahata Y, Hayami S, Ueno M, Yamaue H.
  • Journal Title: Ann Surg. Volume: 269 Issue: 2 Pages: 243-251
  • DOI: 10.1097/sla.0000000000002802
  • Peer Reviewed
• [Journal Article] MAPLE-PD trial (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy): study protocol for a multicenter randomized controlled trial of 354 patients with pancreatic ductal adenocarcinoma (2018)
  • Author(s): Hirono S, Kawai M, Okada KI, Fujii T, Sho M, Satoi S, Amano R, Eguchi H, Mataki Y, Nakamura M, Matsumoto I, Baba H, Tani M, Kawabata Y, Nagakawa Y, Yamada S, Murakami Y, Shimokawa T, Yamaue H.
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 613-613
  • DOI: 10.1186/s13063-018-3002-z
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma. (2018)
  • Author(s): Shigekawa Y, Hayami S, Ueno M, Miyamoto A, Suzaki N, Kawai M, Hirono S, Okada KI, Hamamoto R, Yamaue H.
  • Journal Title: Oncotarget Volume: 9 Issue: 76 Pages: 34320-34335
  • DOI: 10.18632/oncotarget.26144
  • Peer Reviewed / Open Access
• [Journal Article] Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN-PD. (2018)
  • Author(s): Maeda H, Okada KI, Fujii T, Oba MS, Kawai M, Hirono S, Kodera Y, Sho M, Akahori T, Shimizu Y, Ambo Y, Kondo N, Murakami Y, Ohuchida J, Eguchi H, Nagano H, Sakamoto J, Yamaue H.
  • Journal Title: Oncol Lett. Volume: 16 Pages: 6847-6853
  • DOI: 10.3892/ol.2018.9422
  • Peer Reviewed / Open Access
• [Journal Article] Outcomes of 1,639 hepatectomies for non-colorectal non-neuroendocrine liver metastases: a multicenter analysis. (2018)
  • Author(s): Sano K, Yamamoto M, Mimura T, Endo I, Nakamori S, Konishi M, Miyazaki M, Wakai T, Nagino M, Kubota K, Unno M, Sata N, Yamamoto J, Yamaue H, Takada T; Japanese Society of Hepato-Biliary-Pancreatic Surgery.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 25 Issue: 11 Pages: 465-475
  • DOI: 10.1002/jhbp.587
  • Peer Reviewed
• [Journal Article] Learning curve and surgical factors influencing the surgical outcomes during the initial experience with laparoscopic pancreaticoduodenectomy. (2018)
  • Author(s): Nagakawa Y, Nakamura Y, Honda G, Gotoh Y, Ohtsuka T, Ban D, Nakata K, Sahara Y, Velasquez VVDM, Takaori K, Misawa T, Kuroki T, Kawai M, Morikawa T, Yamaue H, Tanabe M, Mou Y, Lee WJ, Shrikhande SV, Conrad C, Han HS, Tang CN, Palanivelu C, Kooby DA, Asbun HJ, Wakabayashi G, Tsuchida A, Takada T, Yamamoto M, Nakamura M.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 25 Issue: 11 Pages: 498-507
  • DOI: 10.1002/jhbp.586
  • Peer Reviewed
• [Journal Article] Intensive perioperative rehabilitation improves surgical outcomes after pancreaticoduodenectomy (2018)
  • Author(s): Kitahata Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kobayashi R, Ueno M, Hayami S, Shimokawa T, Kouda K, Tajima F, Yamaue H.
  • Journal Title: Langenbeck's Archives of Surgery Volume: 403 Issue: 6 Pages: 711-718
  • DOI: 10.1007/s00423-018-1710-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Endoscopic treatment of esophageal fistulas after esophagectomy with injection of an alpha-cyanoacrylate monomer: a phase II study. (2018)
  • Author(s): Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Tsuji T, Maruoka S, Yamaue H.
  • Journal Title: Endoscopy International Open Volume: 6 Issue: 09 Pages: E1093-E1099
  • DOI: 10.1055/a-0581-9005
  • Peer Reviewed / Open Access
• [Journal Article] Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and S-1 for Resectable Advanced Esophageal Cancer. (2018)
  • Author(s): Hayata K, Ojima T, Nakamori M, Nakamura M, Katsuda M, Kitadani J, Takeuchi A, Tabata H, Maruoka S, Yamaue H.
  • Journal Title: Anticancer Research Volume: 38 Issue: 9 Pages: 5267-5273
  • DOI: 10.21873/anticanres.12852
  • Peer Reviewed / Open Access
• [Journal Article] Reinforced Stapling Technique for Reconstruction After Laparoscopic Distal Gastrectomy. (2018)
  • Author(s): Ojima T, Nakamura M, Hayata K, Nakamori M, Yamaue H.
  • Journal Title: Surgical Laparoscopy Endoscopy Percutaneous Techniques Volume: 28 Issue: 5 Pages: 334-336
  • DOI: 10.1097/sle.0000000000000570
  • Peer Reviewed
• [Journal Article] Identification of a novel HLA-A24-restricted cytotoxic T lymphocyte epitope peptide derived from mesothelin in pancreatic cancer. (2018)
  • Author(s): Tsukagoshi M, Wada S, Hirono S, Yoshida S, Yada E, Sasada T, Shirabe K, Kuwano H, Yamaue H.
  • Journal Title: Oncotarget. Volume: 9 Issue: 59 Pages: 31448-31458
  • DOI: 10.18632/oncotarget.25837
  • Peer Reviewed / Open Access
• [Journal Article] Difficulty scoring system in laparoscopic distal pancreatectomy. (2018)
  • Author(s): Ohtsuka T, Ban D, Nakamura Y, Nagakawa Y, Tanabe M, Gotoh Y, Velasquez VVDM, Nakata K, Sahara Y, Takaori K, Honda G, Misawa T, Kawai M, Yamaue H, Morikawa T, Kuroki T, Mou Y, Lee WJ, Shrikhande SV, Tang CN, Conrad C, Han HS, Palanivelu C, Asbun HJ, Kooby DA, Wakabayashi G, Takada T, Yamamoto M, Nakamura M.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 25 Issue: 11 Pages: 489-497
  • DOI: 10.1002/jhbp.578
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It. (2018)
  • Author(s): Klompmaker S, Boggi U, Hackert T, Salvia R, Weiss M, Yamaue H, Zeh HJ, Besselink MG.
  • Journal Title: J Gastrointest Surg. Volume: 22 Issue: 10 Pages: 1804-1810
  • DOI: 10.1007/s11605-018-3894-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Significance of hepatic resection and adjuvant hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombus in the first branch of portal vein and the main portal trunk: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. (2018)
  • Author(s): Hatano E, Uemoto S, Yamaue H, Yamamoto M; Japanese Society of Hepato-Biliary-Pancreatic Surgery.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 25 Issue: 9 Pages: 395-402
  • DOI: 10.1002/jhbp.574
  • Peer Reviewed
• [Journal Article] Resection for recurrent pancreatic cancer in the remnant pancreas after pancreatectomy is clinically promising: Results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. (2018)
  • Author(s): Yamada S, Kobayashi A, Nakamori S, Baba H, Yamamoto M, Yamaue H, Fujii T.
  • Journal Title: Surgery. Volume: 164 Issue: 5 Pages: 1049-1056
  • DOI: 10.1016/j.surg.2018.05.050
  • Peer Reviewed
• [Journal Article] Robotic versus laparoscopic gastrectomy with lymph node dissection for gastric cancer: study protocol for a randomized controlled trial (2018)
  • Author(s): Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 409-409
  • DOI: 10.1186/s13063-018-2810-5
  • Peer Reviewed / Open Access
• [Journal Article] Splenic vein resection together with the pancreatic parenchyma versus separated resection after isolation of the parenchyma during distal pancreatectomy (COSMOS-DP trial): study protocol for a randomised controlled trial (2018)
  • Author(s): Yamada S, Fujii T, Kawai M, Shimokawa T, Nakamura M, Murakami Y, Satoi S, Eguchi H, Nagakawa Y, Kodera Y, Yamaue H.
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 369-369
  • DOI: 10.1186/s13063-018-2756-7
  • Peer Reviewed / Open Access
• [Journal Article] Minimally invasive preservation versus splenectomy during distal pancreatectomy: a systematic review and meta-analysis. (2018)
  • Author(s): Nakata K, Shikata S, Ohtsuka T, Ukai T, Miyasaka Y, Mori Y, Velasquez VVDM, Gotoh Y, Ban D, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 25 Issue: 11 Pages: 476-488
  • DOI: 10.1002/jhbp.569
  • Peer Reviewed
• [Journal Article] Clinical impact of developing better practices at the institutional level on surgical outcomes after distal pancreatectomy in 1515 patients: Domestic audit of the Japanese Society of Pancreatic Surgery. (2018)
  • Author(s): Satoi S, Yamamoto T, Motoi F, Matsumoto I, Yoshitomi H, Amano R, Tahara M, Murakami Y, Arimitsu H, Hirono S, Sho M, Ryota H, Ohtsuka M, Unno M, Takeyama Y, Yamaue H.
  • Journal Title: Ann Gastroenterol Surg. Volume: 25 Issue: 3 Pages: 212-219
  • DOI: 10.1002/ags3.12066
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers. (2018)
  • Author(s): Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
  • Journal Title: Oncotarget. Volume: 9 Issue: 38 Pages: 25075-25088
  • DOI: 10.18632/oncotarget.25308
  • Peer Reviewed / Open Access
• [Journal Article] Phase I/II Trial of Chemotherapy with Docetaxel, Cisplatin, and S-1 for Unresectable Advanced Squamous Cell Carcinoma of the Esophagus (2018)
  • Author(s): Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Maruoka S, Shimokawa T, Yamaue H.
  • Journal Title: Oncology Volume: 95 Issue: 2 Pages: 116-120
  • DOI: 10.1159/000488861
  • Peer Reviewed
• [Journal Article] Fundoplication with 180-Degree Wrap During Esophagogastrostomy After Robotic Proximal Gastrectomy for Early Gastric Cancer. (2018)
  • Author(s): Ojima T, Nakamori M, Nakamura M, Hayata K, Maruoka S, Yamaue H.
  • Journal Title: Journal of Gastrointestinal Surgery Volume: 22 Issue: 8 Pages: 1475-1476
  • DOI: 10.1007/s11605-018-3765-2
  • Peer Reviewed
• [Journal Article] A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer. (2018)
  • Author(s): Sunder R et al.
  • Journal Title: BMC cancer Volume: 27 Issue: 1 Pages: 332-332
  • DOI: 10.1186/s12885-018-4234-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cancer Vaccine Therapy Using Carcinoembryonic Antigen - expressing Dendritic Cells generated from Induced Pluripotent Stem Cells (2018)
  • Author(s): Kitadani Junya、Ojima Toshiyasu、Iwamoto Hiromitsu、Tabata Hirotaka、Nakamori Mikihito、Nakamura Masaki、Hayata Keiji、Katsuda Masahiro、Miyajima Masayasu、Yamaue Hiroki
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 4569-4569
  • DOI: 10.1038/s41598-018-23120-z
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer (2017)
  • Author(s): Yamaue H et al.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 79 Pages: 813-823
  • Peer Reviewed
• [Journal Article] Phase II clinical trial using novel peptide cocktail vaccine as a postoperative adjuvant treatment for surgically resected pancreatic cancer patients. (2017)
  • Author(s): Miyazawa M, Katsuda M, Maguchi H, Katanuma A, Ishii H, Ozaka M, Yamao K, Imaoka H, Kawai M, Hirono S, Okada KI, Yamaue H.
  • Journal Title: Int J Cancer. Volume: 140 Issue: 4 Pages: 973-982
  • DOI: 10.1002/ijc.30510
  • Peer Reviewed
• [Journal Article] Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer. (2017)
  • Author(s): Yamaue H, Shimizu A, Hagiwara Y, Sho M, Yanagimoto H, Nakamori S, Ueno H, Ishii H, Kitano M, Sugimori K, Maguchi H, Ohkawa S, Imaoka H, Hashimoto D, Ueda K, Nebiki H, Nagakawa T, Isayama H, Yokota I, Ohashi Y, Shirasaka T.
  • Journal Title: Cancer Chemother Pharmacol. Volume: in press Issue: 4 Pages: 813-823
  • DOI: 10.1007/s00280-017-3250-8
  • Peer Reviewed
• [Journal Article] Phase I Study of Nab-Paclitaxel plus Gemcitabine as Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer (2017)
  • Author(s): Okada KI et al.
  • Journal Title: Anticancer Res Volume: 37 Pages: 853-858
  • Peer Reviewed
• [Journal Article] Treatment Strategy for Borderline Resectable Pancreatic Cancer With Radiographic Artery Involvement. Pancreas (2016)
  • Author(s): Hirono S et al.
  • Journal Title: Pancreas Volume: 45 Pages: 1438-1446
  • Peer Reviewed
• [Journal Article] Impact of treatment duration of neoadjuvant FIRINOX in patients with borderline resectable pancreatic cancer: a pilot trial. (2016)
  • Author(s): Okada K., Ioka T., et al.
  • Journal Title: Cancer Chemother. Pharmacol. Volume: 78(4) Issue: 4 Pages: 719-26
  • DOI: 10.1007/s00280-016-3121-8
  • Peer Reviewed
• [Presentation] iPS細胞由来樹状細胞を用いたテーラーメード癌ワクチン療法 (2018)
  • Author(s): 尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 中森幹人 中村公紀 勝田将裕 早田啓治 丸岡慎平 山上裕機
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] iPS細胞由来樹状細胞を用いたテーラーメード癌ワクチン療法の現状と未来 (2018)
  • Author(s): 尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 中森幹人 中村公紀 勝田将裕 早田啓治 丸岡慎平 山上裕機
  • Organizer: 第31回日本バイオセラピー学会学術集会
• [Presentation] iPS細胞由来樹状細胞を用いた癌ワクチン療法 (2018)
  • Author(s): 尾島敏康
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 難治性胃癌に対する癌治療用ウイルスの開発と期待 (2017)
  • Author(s): 中森幹人
  • Organizer: 第55回日本癌治療学会総会
• [Presentation] 1.Antitumor efficacy of hTERT promoter regulated oncolytic herpes simplex viruses for human gastric cancer (2016)
  • Author(s): 中森幹人、加藤智也、松村修一、福原浩、稲生靖、藤堂具紀、山上裕機
  • Organizer: 第22回日本遺伝子細胞治療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-29
• [Remarks] iPS細胞由来樹状細胞を用いて消化器固形癌に対するワクチン効果を初めて確認
  • URL: http://www.wakayama-med.ac.jp/intro/press/201803/01.html