Identification of the novel therapeutic targets for CRPC by using newly developed AR-V7 expressing prostate cancer cell lines
| Project/Area Number |
16K15686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杉山 愛子 京都大学, 医学研究科, 特定研究員 (30642699)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | CRPC / 前立腺癌 / shRNA library screening / 治創薬標的遺伝子 / 腫瘍学 |
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| Outline of Final Research Achievements |
Recently, the number of patients who died in prostate cancer is increasing. One of the most significant difficulties of the translational research of this cancer is that it is so hard to establish cell lines. To overcome these, we newly established a cell lines by culturing the androgen-dependent LNCaP cells under the androgen depleted condition. By using these cell lines, we have successfully identified several genes critical for the androgen-independent cell growth of prostate cancer cells. These might be potent therapeutic targets for the disease.
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Report
(3 results)
Research Products
(3 results)
