Investigation of the mechanism how dietary foods influence on progression of ovarian cancer.

• Project/Area Number: 16K15707
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kindai University (2017); Kyoto University (2016)
• Principal Investigator: MATSUMURA Noriomi 近畿大学, 医学部, 教授 (20452336)
• Co-Investigator(Kenkyū-buntansha): 安彦 郁 京都大学, 医学(系)研究科(研究院), その他 (20508246) ; 越山 雅文 京都大学, 医学研究科, 客員研究員 (50724390) ; 小西 郁生 京都大学, 医学研究科, 名誉教授 (90192062)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 卵巣癌 / 食品 / 動物性タンパク質 / 植物性タンパク質 / 癌

Outline of Final Research Achievements

We evaluated whether different dietary protein qualities (isocaloric diets involving animal or plant protein) could inhibit the ovarian cancer growth in mice. In the mice of the 20% plant protein group, the ovarian cancer growth was reduced in comparison to the mice in the 20% animal protein group. The serum levels of insulin and IGF-1 levels were both lower in the mice of the 20% plant protein group than in the mice of the 20% animal protein group. Immunohistochemistry revealed that the level of p-4EBP1 (one of the major downstream effectors of the mTOR pathway) of the plant protein group was weaker than that of the animal protein group. Our findings suggest that a diet high in plant protein reduces the growth of human ovarian cancer cells in mice compared to a diet high in animal protein, possibly through the lack of activation of the IGF/Akt/mTOR pathway.

Research Products

• [Journal Article] Recurrence of uterine myoma after myomectomy: open myomectomy versus laparoscopic myomectomy. (2018)
  • Author(s): Kotani Y, Tobiume T, Fujishima R, Shigeta M, Takaya H, Nakai H, Suzuki A, Tsuji I, Mandai M, Matsumura N
  • Journal Title: J Obstet Gynaecol Res Volume: 44 Issue: 2 Pages: 298-302
  • DOI: 10.1111/jog.13519
  • NAID: 120006457109
  • Peer Reviewed
• [Journal Article] Effectiveness of adjuvant systemic chemotherapy for intermediate-risk stage IB cervical cancer (2017)
  • Author(s): Matsuo Koji、Shimada Muneaki、Yokota Harushige、Satoh Toyomi、Katabuchi Hidetaka、Kodama Shoji、Sasaki Hiroshi、Matsumura Noriomi、Mikami Mikio、Sugiyama Toru
  • Journal Title: Oncotarget Volume: 8 Issue: 63 Pages: 106866-106875
  • DOI: 10.18632/oncotarget.22437
  • NAID: 120007134533
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pneumocystis Pneumonia in Non-HIV Pregnant Women Receiving Chemotherapy for Malignant Lymphoma: Two Case Reports. (2017)
  • Author(s): Fukutani Y, Chigusa Y, Kondoh E, Kawasaki K, Io S, Matsumura N.
  • Journal Title: Case Rep Obstet Gynecol. Volume: 2017 Pages: 1073146-1073146
  • DOI: 10.1155/2017/1073146
  • Peer Reviewed
• [Journal Article] Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks. (2017)
  • Author(s): Murakami R, Matsumura N, Brown JB, Higasa K, Tsutsumi T, Kamada M, Abou-Taleb H, Hosoe Y, Kitamura S, Yamaguchi K, Abiko K, Hamanishi J, Baba T, Koshiyama M, Okuno Y, Yamada R, Matsuda F, Konishi I, Mandai M.
  • Journal Title: The American Journal of Pathology Volume: 187 Issue: 10 Pages: 2246-2258
  • DOI: 10.1016/j.ajpath.2017.06.012
  • Peer Reviewed / Open Access
• [Journal Article] Distinct preoperative clinical features predict four histopathological subtypes of high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum. (2017)
  • Author(s): Ohsuga T, Yamaguchi K, Kido A, Murakami R, Abiko K, Hamanishi J, Kondoh E, Baba T, Konishi I, Matsumura N.
  • Journal Title: BMC Cancer Volume: 17 Issue: 1 Pages: 580-580
  • DOI: 10.1186/s12885-017-3573-1
  • Peer Reviewed
• [Journal Article] Unenhanced region on magnetic resonance imaging represents tumor progression in uterine carcinosarcoma. (2017)
  • Author(s): Inoue A, Yamaguchi K, Kurata Y, Murakami R, Abiko K, Hamanishi J, Kondoh E, Baba T, Kido A, Konishi I, Matsumura N
  • Journal Title: J Gynecol Oncol Volume: 28 Issue: 5
  • DOI: 10.3802/jgo.2017.28.e62
  • Peer Reviewed
• [Journal Article] Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma. (2017)
  • Author(s): Bixel K, Saini U, Kumar Bid H, Fowler J, Riley M, Wanner R, Deepa Priya Dorayappan K, Rajendran S, Konishi I, Matsumura N, Cohn DE, Selvendiran K.
  • Journal Title: Int J Cancer. Volume: 141 Issue: 9 Pages: 1856-1866
  • DOI: 10.1002/ijc.30847
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diet and Physical Activity after Ovarian Cancer Diagnosis (2017)
  • Author(s): Matsumura N
  • Journal Title: Acta Medica Kindai University Volume: 42 Pages: 37-42
• [Journal Article] Combination of Aprepitant, Azasetron, and Dexamethasone as Antiemetic Prophylaxis in Women with Gynecologic Cancers Receiving Paclitaxel/Carboplatin Therapy. (2017)
  • Author(s): Koshiyama M, Matsumura N, Imai S, Yamanoi K, Abiko K, Yoshioka Y, Yamaguchi K, Hamanishi J, Baba T, Konishi I.
  • Journal Title: Med Sci Monit. Volume: 23 Pages: 826-33
  • DOI: 10.12659/msm.899741
  • NAID: 120005997749
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells. (2017)
  • Author(s): Horikawa N, Abiko K, Matsumura N, Hamanishi J, Baba T, Yamaguchi K, Yoshioka Y, Koshiyama M, Konishi I.
  • Journal Title: Clin Cancer Res. Volume: Jan 15;23(2) Issue: 2 Pages: 587-599
  • DOI: 10.1158/1078-0432.ccr-16-0387
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Groin lymph node detection and sentinel lymph node biopsy in vulvar cancer. (2016)
  • Author(s): Sakae C, Yamaguchi K, Matsumura N, Nakai H, Yoshioka Y, Kondoh E, Hamanishi J, Abiko K, Koshiyama M, Baba T, Kido A, Mandai M, Konishi I
  • Journal Title: J Gynecol Oncol. Volume: 27 Issue: 6
  • DOI: 10.3802/jgo.2016.27.e57
  • NAID: 120005997862
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical Efficacy of Ovarian Cancer Screening. (2016)
  • Author(s): Koshiyama M, Matsumura N, Konishi I
  • Journal Title: J Cancer. Volume: 7 Issue: 10 Pages: 1311-1316
  • DOI: 10.7150/jca.14615
  • NAID: 120006305921
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comprehensive assessment of the expression of the SWI/SNF complex defines two distinct prognostic subtypes of ovarian clear cell carcinoma. (2016)
  • Author(s): Abou-Taleb H, Yamaguchi K, Matsumura N, Murakami R, Nakai H, Higasa K, Amano Y, Abiko K, Yoshioka Y, Hamanishi J, Koshiyama M, Baba T, Yamada R, Matsuda F, Konishi I, Mandai M.
  • Journal Title: Oncotarget. Volume: Aug 23;7(34) Issue: 34 Pages: 54758-54770
  • DOI: 10.18632/oncotarget.10181
  • NAID: 120005820857
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer. (2016)
  • Author(s): Yamanoi K, Matsumura N, Murphy SK, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Koshiyama M, Konishi I, Mandai M.
  • Journal Title: Oncotarget. Volume: Jul 26;7(30) Issue: 30 Pages: 47620-47636
  • DOI: 10.18632/oncotarget.9951
  • NAID: 120005820858
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two cases of Wolffian tumor with novel magnetic resonance imaging findings reflecting characteristic pathology. (2016)
  • Author(s): Sakai M, Abiko K, Matsumura N, Kondoh E, Yamaguchi K, Minamiguchi S, Kurata Y, Kido A, Konishi I.
  • Journal Title: J Obstet Gynaecol Res. Volume: 42 Issue: 8 Pages: 1046-1051
  • DOI: 10.1111/jog.13020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Magnetic resonance imaging findings and prognosis of gastric-type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports. (2016)
  • Author(s): Hino M, Yamaguchi K, Abiko K, Yoshioka Y, Hamanishi J, Kondoh E, Koshiyama M, Baba T, Matsumura N, Minamiguchi S, Kido A, Konishi I.
  • Journal Title: Mol Clin Oncol. Volume: 4 Issue: 5 Pages: 699-704
  • DOI: 10.3892/mco.2016.789
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tubo-ovarian abscess with endometrial cyst probably infected by Campylobacter fetus: Two cases. (2016)
  • Author(s): Kitamura S, Matsumura N, Ohtake N, Kita M, Konishi I.
  • Journal Title: J Obstet Gynaecol Res. Volume: 42 Issue: 8 Pages: 1052-1057
  • DOI: 10.1111/jog.13004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles. (2016)
  • Author(s): Murakami R, Matsumura N, Brown JB, Wang Z, Yamaguchi K, Abiko K, Yoshioka Y, Hamanishi J, Baba T, Koshiyama M, Mandai M, Yamada R, Konishi I.
  • Journal Title: Gynecol Oncol. Volume: 141 Issue: 1 Pages: 49-56
  • DOI: 10.1016/j.ygyno.2016.02.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes. (2016)
  • Author(s): Murakami R, Matsumura N, Mandai M, Yoshihara K, Tanabe H, Nakai H, Yamanoi K, Abiko K, Yoshioka Y, Hamanishi J, Yamaguchi K, Baba T, Koshiyama M, Enomoto T, Okamoto A, Murphy SK, Mori S, Mikami Y, Minamiguchi S, Konishi I
  • Journal Title: Am J Pathol. Volume: 186 Issue: 5 Pages: 1103-13
  • DOI: 10.1016/j.ajpath.2015.12.029
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical efficacy of neoadjuvant chemotherapy with irinotecan (CPT-11) and nedaplatin followed by radical hysterectomy for locally advanced cervical cancer. (2016)
  • Author(s): Abou-Taleb HA, Koshiyama M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J, Abiko K, Yamanoi K, Murakami R, Horikawa N, Taha AA, Kitamura S, Konishi I.
  • Journal Title: J Int Med Res. Volume: 44 Issue: 2 Pages: 346-356
  • DOI: 10.1177/0300060515591858
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-a potential therapeutic target. (2015)
  • Author(s): Peng J, Yoshioka Y, Mandai M, et al
  • Journal Title: Mol Carcinog Volume: Epub ahead of print Issue: 4 Pages: 1-11
  • DOI: 10.1002/mc.22283
  • Peer Reviewed / Open Access
• [Presentation] The resistance to anti-VEGF therapy in ovarian cancer is mediated through recruitment of hypoxia-induced MDSC. (2017)
  • Author(s): Naoki Horikawa, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Ken Yamaguchi, Ikuo Konishi, Noriomi Matsumura
  • Organizer: 第69回日本産科婦人科学会学術講演会
  • Place of Presentation: 広島グリーンアリーナ
  • Year and Date: 2017-04-13
• [Presentation] The impact of anti-PD-1 antibody Nivolumab on chemo-sensitivity of platinum-resistant recurrent ovarian cancer. (2017)
  • Author(s): Yoshihide Inayama, Junzo Hamanishi, Masaki Mandai, Noriomi Matsumura, Kaoru Abiko, Ryusuke Murakami, Ken Yamaguchi, Tsukasa Baba, Ikuo Konishi
  • Organizer: 第69回日本産科婦人科学会学術講演会
  • Place of Presentation: 広島グリーンアリーナ
  • Year and Date: 2017-04-13
• [Presentation] Suppression of Warburg effect enhances cisplatin sensitivity in ovarian clear cell carcinoma. (2017)
  • Author(s): Sachiko Kitamura, Ken Yamaguchi, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura
  • Organizer: 第69回日本産科婦人科学会学術講演会
  • Place of Presentation: 広島グリーンアリーナ
  • Year and Date: 2017-04-13
• [Presentation] Snail inhibits anti-tumor immunity through upregulation of CXCR2 ligands in ovarian cancer. (2017)
  • Author(s): Mana Taki, Kaoru Abiko, Tsukasa Baba, Junzo Hamanishi, Ken Yamaguchi, Ryusuke Murakami, Naoki Horikawa, Noriomi Matsumura
  • Organizer: 第69回日本産科婦人科学会学術講演会
  • Place of Presentation: 広島グリーンアリーナ
  • Year and Date: 2017-04-13
• [Presentation] HER-2 expression in Gastric type adenocarcinoma of the uterine cervix. (2017)
  • Author(s): Ayano Holmes, Ken Yamaguchi, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Eiji Kondo, Tsukasa Baba, Noriomi Matsumura
  • Organizer: 第69回日本産科婦人科学会学術講演会
  • Place of Presentation: 広島グリーンアリーナ
  • Year and Date: 2017-04-13