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Understanding of dental plaque microbiota in the early stage

Research Project

Project/Area Number 16K15856
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Social dentistry
Research InstitutionKyushu University

Principal Investigator

Takeshita Toru  九州大学, 歯学研究院, 准教授 (50546471)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords初期付着細菌 / デンタルプラーク / マイクロバイオーム / 16S rRNA / 口腔 / う蝕 / 初期プラーク / 口腔マイクロバイオーム / 唾液 / 舌苔 / 16S rRNA遺伝子 / メタゲノム
Outline of Final Research Achievements

Dental plaque is a dynamic microbial biofilm of which the develpment begins with adherence of selected bacteria. This study aimed to understand dental plaque in the early stage. Plaque samples that accumulated on a hydroxyapatite disk for 6 hours were collected from the subjects using a hydroxyapatite disk and analyzed using an open-ended approach using bacterial 16S rRNA gene. This study revealed the detailed bacterial composition of dental plaque in an early stage and identified the predominant bacterial taxa with strong adhesion ability on tooth surfaces. The initial dental plaque assoicated with dental caries was also characterized. Our results would be an important basis for a development of an effective approach to promote oral health.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Relationships of variations in the tongue microbiota and pneumonia mortality in nursing home residents2018

    • Author(s)
      Kageyama S, Takeshita T, Furuta M, Tomioka M, Asakawa M, Suma S, Takeuchi K, Shibata Y, Iwasa Y, Yamashita Y
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: - Issue: 8 Pages: 1097-1102

    • DOI

      10.1093/gerona/glx205

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The oral microbiome and human health2017

    • Author(s)
      Yamashita Y, Takeshita T
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 2 Pages: 201-206

    • DOI

      10.2334/josnusd.16-0856

    • NAID

      130006882396

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis2017

    • Author(s)
      Kageyama S, Takeshita T, Asakawa M, Shibata Y, Takeuchi K, Yamanaka W, Yamashita Y
    • Journal Title

      PLoS One

      Volume: 12 Issue: 4 Pages: e0174782-e0174782

    • DOI

      10.1371/journal.pone.0174782

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] デンタルプラーク形成に関わる初期付着細菌群の特定2017

    • Author(s)
      竹下徹、井原由佳理、影山伸哉、松見理恵、山下喜久
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing2016

    • Author(s)
      竹下 徹
    • Organizer
      第65回日本口腔衛生学会総会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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