Research Project
Grant-in-Aid for Young Scientists (B)
Hypozincemia regarded as a risk for colon cancer and colitis. However, the precise mechanisms involved in zinc deficiency of the intestinal inflammation remains unclear. This study demonstrates that zinc deficiency resulting from using a zinc chelator administration aggravates colonic inflammation through the activation of type 17 helper T (Th17) cells in mice. Flow cytometric analysis revealed that zinc deficiency significantly increases the proportion of pro-inflammatory (M1) macrophages in inflamed colon. A zinc chelator up-regulates IL-23p19 expression, which is deeply associated with Th17 development, in mouse bone marrow-derived macrophages (BMDMs). Furthermore, the nuclear accumulation of interferon-regulatory factor 5 is critically involved in IL-23p19 induction in zinc-deficient BMDMs. Thus, zinc deficiency aggravates colonic inflammation through activation of the IL-23/Th17 axis, and the activation is controlled by subcellular distribution of interferon-regulatory factor 5.
All 2018 2017 2016
All Journal Article (9 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 9 results, Open Access: 2 results, Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Invited: 4 results)
Inflammatory Bowel Diseases
Volume: 24 Issue: 2 Pages: 317-331
10.1093/ibd/izx003
J Gastroenterol Hepatol.
Volume: 33 Issue: 3 Pages: 671-680
10.1111/jgh.13842
Medical Gas Research
Volume: 8 Issue: 1 Pages: 6-6
10.4103/2045-9912.229597
Food Funct.
Volume: 8(7) Issue: 7 Pages: 3176-3183
10.1039/c6fo00177g
Am. J. Physiol. Gastrointest. Liver Physiol.
Volume: 310 Issue: 6 Pages: G367-G375
10.1152/ajpgi.00324.2015
FEBS Lett.
Volume: 590 Issue: 16 Pages: 2690-2699
10.1002/1873-3468.12265
J Control Release.
Volume: 239 Pages: 128-36
10.1016/j.jconrel.2016.08.030
Br. J. Nutr.
Volume: 116(7) Pages: 1199-1205
Nihon Rinsho.
Volume: 74(7) Pages: 1121-1125
40020885811