Development of a real-time optical thrombus sensor for an extracorporeal centrifugal blood pump using visible and near-infrared spectroscopy
Project/Area Number |
16K16384
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
FUJIWARA Tatsuki 東京医科歯科大学, 医学部附属病院, 助教 (00632291)
|
Research Collaborator |
SAKOTA Daisuke 国立研究開発法人 産業技術総合研究所, 健康工学研究部門, 主任研究員 (40588670)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 体外循環 / 補助循環 / 血栓検出 / 血液凝固識別装置 / 遠心ポンプ / ジャイロポンプ / 心臓血管外科 / 遠心血液ポンプ / 血栓 |
Outline of Final Research Achievements |
Pump thrombus remains the weak point of mechanical circulatory support. We have developed a new method for optical continuous monitoring of pump thrombus. This study applied a gyro centrifugal pump. The top pivot bearing is an area at particularly high risk of thrombus formation due to the stagnation of circulating blood. We used visible and near-infrared spectroscopy. The top bearing was illuminated directly overhead by a xenon lamp guided by the incident optical fiber. The scattered light was detected by the detection optical fiber placed at right angles to the incident optical fiber, and was analyzed using a spectrophotometer connected to the detection optical fiber. The system succeeded in real-time monitoring of thrombus formation for both in-vitro and animal experiments using swine as a left ventricular assist device model. This method showed the feasibility of non-invasive, continuous monitoring of pump thrombus without the influence of either oxygen saturation or hematocrit.
|
Report
(3 results)
Research Products
(10 results)
-
[Journal Article] Optical Dynamic Analysis of Thrombus Inside a Centrifugal Blood Pump During Extracorporeal Mechanical Circulatory Support in a Porcine Model.2017
Author(s)
Fujiwara T, Sakota D, Ouchi K, Endo S, Tahara T, Murashige T, Kosaka R, Oi K, Mizuno T, Maruyama O, Arai H.
-
Journal Title
Artificial Organs
Volume: 41
Issue: 10
Pages: 893-903
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
[Presentation] 当院におけるINTERMACS Profile 1に対する治療戦略、遠心ポンプを用いた左心補助の有用性の検証2016
Author(s)
13.藤原立樹, 水野友裕, 大井啓司, 八島正文, 八丸 剛, 長岡英気, 黒木秀仁, 田崎 大, 竹下斉史, 木下亮二, 倉島直樹, 二井奈保子, 古川文子, 大内克洋, 荒井裕国
Organizer
第54回日本人工臓器学会大会
Place of Presentation
米子コンベンションセンター(鳥取県米子市)
Year and Date
2016-11-23
Related Report
-
[Presentation] Which is a better acute-phase circulatory support for cardiogenic shock patients in INTERMACS profile-1: a pulsatile VAD or a centrifugal pump?2016
Author(s)
Fujiwara T, Arai H, Mizuno T, Oi K, Yashima M, Hachimaru T, Nagaoka E, Kuroki H, Tasaki D, Takeshita M, Kinoshita R, Ohuchi K.
Organizer
24th Annual Congress of the International Society for Rotary Blood Pumps
Place of Presentation
Ibaraki, Japan
Year and Date
2016-09-20
Related Report
Int'l Joint Research
-