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Atomoxetine administration combined with intensive rehabilitation therapy for post-stroke

Research Project

Project/Area Number 16K16444
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionJikei University School of Medicine

Principal Investigator

Yamada Naoki  東京慈恵会医科大学, 医学部, 助教 (90756149)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsリハビリテーション / アトモキセチン / SNRI / 脳機能画像 / 経頭蓋磁気刺激 / 脳卒中後遺症 / 高次脳機能障害 / 記憶障害 / 注意障害 / 脳血流 / SNRI / TMS / 脳卒中 / 医療・福祉
Outline of Final Research Achievements

Our proposed combined protocol of atomoxetine administration and rehabilitation methods was safely tolerated, and improved cognitive function in some patients after stroke. Although further studies with a larger number of patients and healthy controls needs to be performed, atomoxetine administration combined with other therapeutic interventions.This study had certain limitations, which will have to be addressed in future studies. First, this study included a relatively small number of subjects with only about ten patients with stroke. The safety and efficacy of atomoxetine administration should be confirmed in a randomized controlled trial with a larger number of patients. Second, the long-term effects of the combined
treatment were not examined. More specifically, this study protocol lasted 4 weeks after beginning the intervention. Third, using various brain imaging analyses of the extent of brain plasticity could be useful to evaluate the effect of combined this protocol.

Academic Significance and Societal Importance of the Research Achievements

アトモキセチン内服併用での経頭蓋磁気刺激(TMS)とリハビリテーションの安全性と有用性を確認し,脳血流画像において全脳における血流改善効果の可能性を認め,報告した.慢性期でありながら,リハビリテーションの効果を最大限に引き出すために,脳の機能変化機能を高める目的でアトモキセチンを投与し,高次脳機能障害の改善も認めた.他にも,ドーパミン系,セロトニン系に作用する薬剤でも,実験レベルでは報告が散見される.今後,こうした脳神経機能変化を促す薬剤の研究が望まれ,脳の機能変化能力を高めた状態でのリハビリテーション提供で,慢性期などの治らないと考えられていた患者に希望を与えうる結果を提供できたと考える.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Relationship between motor function improvements and white matter structure after low-frequency repetitive transcranial magnetic stimulation plus intensive occupational therapy in chronic subcortical stroke patients2019

    • Author(s)
      Ueda Ryo、Yamada Naoki、Abo Masahiro、Senoo Atsushi
    • Journal Title

      NeuroReport

      Volume: 30 Issue: 7 Pages: 485-490

    • DOI

      10.1097/wnr.0000000000001227

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergoing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke2018

    • Author(s)
      Yamada Naoki、Ueda Ryo、Kakuda Wataru、Momosaki Ryo、Kondo Takahiro、Hada Takuya、Sasaki Nobuyuki、Hara Takatoshi、Senoo Atsushi、Abo Masahiro
    • Journal Title

      Neural Plasticity

      Volume: 2018 Pages: 1-8

    • DOI

      10.1155/2018/3901016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atomoxetine administration combined with intensive speech therapy for post-stroke aphasia: evaluation by a novel SPECT method2016

    • Author(s)
      Yamada N, Kakuda W, Yamamoto K, Momosaki R, Abo M.
    • Journal Title

      International Journal of Neuroscience

      Volume: 126 Issue: 9 Pages: 829-838

    • DOI

      10.3109/00207454.2015.1074226

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Atomoxetine administration combined with rehabilitationfor poststroke cognitive dysfunction2017

    • Author(s)
      Yamada N
    • Organizer
      第54回リハビリテーション医学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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