| Project/Area Number |
16K16606
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
Takahashi YUKI
Okawara SHIORI
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性腎臓病 / ポドサイト傷害 / 糸球体傷害 / 尿細管間質傷害 / Tpir / Ttir / コンジェニック解析 |
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| Outline of Final Research Achievements |
Increasing numbers of patients with chronic kidney disease has emerged as a social problem. Using mouse genetic method, I have identified two genetic loci resistant to podocyte injury and tubulointerstitial injury, respectively. In this study, a genome-wide linkage analysis of backcrosses between susceptible FVB/NJ- and resistant C57BL/6J-derived mouse strains to podocyte injury detected a novel major modifier locus on chromosome 10. To identify candidate genes for these genetic loci, I performed exome and transcriptome analyses comparing susceptible and resistant mouse strains. The identification of these responsible genes could lead to the development of new treatment strategies for chronic kidney disease.
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