Development of new method for screening anticancer drugs that target topoisomerases by using DNA origami
Project/Area Number |
16K17934
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Bio-related chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | DNA origami / Inhibitors / Topoisomerase / HS-AFM / Drug screening / Single-molecule analysis / Rotaxane / Catenane / DNA rotaxanes / DNA catenane / Topoisomerase inhibitors / high speed AFM / ナノバイオ / High-Speed AFM |
Outline of Final Research Achievements |
The supramolecular assemblies of the topologically interlocked components inside a DNA origami were constructed. Such assemblies of the functional structures are promising in the fields of molecular switches, motors, sensors, and logic devices.
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Report
(3 results)
Research Products
(11 results)