Mechanisms of human LINE-1 retrotransposition
| Project/Area Number |
16K18471
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ヒトゲノム / 転移因子 / LINE-1 / DNA修復 / ゲノム恒常性 / L1 / レトロトランスポゾン / ゲノム / 転移 / 遺伝学 / 進化 |
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| Outline of Final Research Achievements |
Retrotransposons, mobile genetic elements, mobilize to other genomic loci. It can act as a mutagen inducing several diseases including cancer. However, it remains to be solved how these elements have spread out into the genome for a long evolutionary time scale. This study focused on the mechanisms of retrotransposition of LINE-1, which is actively and currently retrotransposed in the human genome. It have been so far demonstrated that diverse DNA repair factors form a complex with LINE-1 and that PARP1 and PARP2 among the interactors especially play a vital role in LINE-1 retrotransposition. These data also suggest a new model in which these DNA repair factors fix DNA breaks induced by LINE-1 by recruiting another DNA repair protein during the retrotransposition cycle.
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Report
(3 results)
Research Products
(5 results)
