Development of a mathematical method for analyzing deformation dynamics of living tissues by 4D variational analysis
Project/Area Number |
16K18578
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
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Research Institution | Ehime University |
Principal Investigator |
Saitou Takashi 愛媛大学, 医学部附属病院, 助教(病院教員) (60588705)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 形態形成 / シミュレーション / バイオイメージング / 小型魚類 / 胚発生 / ライブイメージング / データ同化 |
Outline of Final Research Achievements |
Development of advanced techniques that fully utilize information from experimental data is a challenging task. In this study, we aimed to advance integration of four dimensional measurement data obtained through fluorescent live imaging analysis and numerical simulation data from mathematical models. Applying the method to the time series data describing cell state changes, deformation dynamics of living tissues were investigated.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] The HIV co-receptor CCR5 regulates osteoclast function.2017
Author(s)
Lee JW, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, Ueha S, Matsushima K, Yamaguchi A, Imai Y, Iimura T.
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Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 2226-2226
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM).2016
Author(s)
Yamamoto S, Oshima Y, Saitou T, Watanabe T, Miyake T, Yoshida O, Tokumoto Y, Abe M, Matsuura B, Hiasa Y, Imamura T
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Journal Title
Biochemistry and Biophysics Reports
Volume: 8
Pages: 277-283
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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