Elucidation of the molecular mechanisms of zinc-induced sleep
| Project/Area Number |
16K18698
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Yoan Cherasse 筑波大学, 国際統合睡眠医科学研究機構, 研究員 (60544319)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | sleep / zinc / actigraphy / chemogenetics / Sleep / optogenetics / DREADD / food supplement / neuroscience / molecular mechanisms |
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| Outline of Final Research Achievements |
First, we examined the effect of zinc-rich and astaxanthin-containing food on sleep in humans. We conducted a randomized, double-blinded, placebo-controlled parallel group trial of 120 healthy subjects and recorded their night activity by actigraphy for 12 weeks.
The examination demonstrated that eating zinc-rich food improved sleep onset latency as well as improved the sleep efficiency. Based on the results, we developed a food supplement to promote sleep, and Fujifilm Healthcare Corporation released it on the market as “Oxybarrier Suttone Rich”.
In addition, we performed experiments on mice to understand the molecular mechanisms of the examination, and identified a population of neurons in the brain which are activated by zinc administration. Stimulating these neurons permitted to increase the amount of sleep similarly to zinc administration.
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| Academic Significance and Societal Importance of the Research Achievements |
The annual economic loss to Japanese economy due to sleep disorders is equivalent to 2.92% of the GDP, costing approx. 15兆円. Optimizing the effect of zinc-induced sleep will allow us to develop food supplements specifically designed to counteract sleep restriction and improve life quality.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2018
Author(s)
Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
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Journal Title
Neuropharmacology
Volume: 144
Pages: 122-132
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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