Analysis of Molecular mechanism underlying improvement of skeletal muscle functions by bile acid.
| Project/Area Number |
16K18699
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Sasaki Takashi 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (90771676)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胆汁酸 / 骨格筋 / サルコペニア / TGR5 / 機能性食品成分 / 筋肥大 / GPCR / 筋細胞分化 / 機能性食品 / 糖尿病 |
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| Outline of Final Research Achievements |
In this study, we analyzed the molecular mechanism underlying improvement of skeletal muscle functions by bile acid. We revealed that bile acid receptor TGR5 promotes muscle hypertrophy and muscle cell differentiation. Furthermore, TGR5 KO mice exhibited muscular atrophy and weakness.Therefore, TGR5 may be a feasible target for maintaining muscle function in the elderly.
We have already found several food compounds that can activate TGR5. These functional food compounds could contribute to improving the muscle function of elderly people.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model.2017
Author(s)
Sasaki, T., Mita, M., Ikari, N., Kuboyama, A., Hashimoto, S., Kaneko, T., Ishiguro, M., Shimizu, M., Inoue, J., and Sato, R.
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Journal Title
PLoS ONE
Volume: 12
Issue: 6
Pages: e0179226-e0179226
DOI
Related Report
Peer Reviewed / Open Access
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