Efficient synthesis of nitrogen-containing compounds with yanamides
| Project/Area Number |
16K18842
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | イナミド / 酸 / 中員環合成 / 生物活性物質 / インドリン / 中員環 / 複素環 / 有機化学 / 薬学 |
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| Outline of Final Research Achievements |
We have developed an efficient cyclization reaction with the formation of keteneiminium as a key intermediate by acid to ynamide. Succeeded in constructing a spiroindoline skeleton at once by a continuous cyclization reaction using an ynamide containing enamide with an external nucleophile. In addition, it was possible to synthesize medium heterocyclic ring, which is generally difficult to synthesize, by using ynamide.
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Report
(3 results)
Research Products
(4 results)
