| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We have developed an efficient cyclization reaction with the formation of keteneiminium as a key intermediate by acid to ynamide. Succeeded in constructing a spiroindoline skeleton at once by a continuous cyclization reaction using an ynamide containing enamide with an external nucleophile. In addition, it was possible to synthesize medium heterocyclic ring, which is generally difficult to synthesize, by using ynamide.
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