| Project/Area Number |
16K18966
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | トランスポーター / 裏打ちタンパク質 / 炎症 / サイトカイン / ERMタンパク質 / 肝細胞 / リン酸化 / radixin / MRP2 / 薬学 / 生体分子 / プロテオーム |
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| Outline of Final Research Achievements |
Inflammation affects pharmacokinetics of various drugs via alterations of metabolic enzymes and transporters expression. Plasma membrane localization of transporters such as P-glycoprotein and MRPs are regulated by scaffold proteins such as ERM proteins (ezrin/radixin/moesin). However, the effects of inflammation on the phosphorylation of ERM proteins and transporter activities remain unclear.
Thise study demonstrated that some inflammatory factors decrease the ratios of phosphorylated radixin in liver.
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