| Project/Area Number |
16K19342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | pancreatic cancer / metabolomics / screening / biomarker / メタボロミクス / IPMN / 膵がん / バイオマーカー / 質量分析 / 血液 / 膵液 / MS |
|---|
| Outline of Final Research Achievements |
The aim of this study was to establish pancreatic disease screening and grade evaluation system using metabolomics with blood and pancreatic juice. Blood samples were collected by 2 independent groups. In the 1st set (55 patients and 58 controls), Model Y, consisting of histidine and xylitol, possessed higher sensitivity (70.4%) than CA19-9. In the 2nd set (16 patients and 16 controls), model Y with CA19-9 displayed high sensitivity (81.3%) and specificity (93.8%). In particular, it displayed very high sensitivity (100%) for resectable PC.
These quantitative analysis confirmed that metabolomics-based diagnostic methods are useful for detecting pancreatic cancer early.
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