Spontaneous activity and regulatory mechanisms of rectal microvessels
| Project/Area Number |
16K19361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Mitsui Retsu 名古屋市立大学, 大学院医学研究科, 講師 (90434092)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細動脈 / 平滑筋 / 周皮細胞 / カルシウムイメージング / 自発活動 / Cl-チャネル / 電位依存性Ca2+チャネル / ギャップ結合 / 自発Ca2+上昇 / Ca2+チャネル / 血管平滑筋 / 塩素イオンチャネル / 電位依存性カルシウムイオンチャネル / Ｔ型カルシウムイオンチャネル / L型カルシウムイオンチャネル / 生理学 / 循環器 |
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| Outline of Final Research Achievements |
The mural cells (vascular smooth muscle cells and pericytes) of rectal arterioles periodically exhibited synchronous, spontaneous rise in intracellular Ca2+ concentration. These spontaneous Ca2+ transients depended on Ca2+ release from endoplasmic reticulum Ca2+ store and subsequent Ca2+-activated Cl- channel opening-mediated Cl- efflux which are expected to cause membrane depolarisation. The depolarisation appeared to be large enough to electrically couple the mural cells connected via gap junctions. Subsequent Ca2+ influxes through T-type (TVDCCs) and L-type (LVDCCs) voltage-dependent Ca2+ channels underlay ‘synchronous’ spontaneous Ca2+ transients among the mural cells. The openings of TVDCCs and LVDCCs increased Ca2+ transient frequency and duration, respectively. The synchronous spontaneous Ca2+ transients in the mural cells may underlie the spontaneous constrictions of arterioles to prevent the rectum from ischemic damage during the prolonged wall distension by faecal pellets.
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Report
(3 results)
Research Products
(8 results)
