| Project/Area Number |
16K19556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAWATSUBASHI Shun 徳島大学, 先端酵素学研究所(オープンイノベ), 特任講師 (70535103)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ビタミンD / ビタミンD受容体 / 皮膚 / 毛包 / 核内受容体 / S100A8 / 毛周期 / 乾癬 / 表皮 / 内分泌学 |
|---|
| Outline of Final Research Achievements |
The in vivo function of vitamin D receptor (VDR) in skin is still unknown. To elucidate VDR function in epidermal development and homeostasis, we generated epidermis-specific VDR KO mice (VDR epiKO). The VDR epiKO mice shows epidermal thickness and hair loss phenotypes. As a result of microarray analysis, it was revealed that S100A8 gene expression was upregulated in VDR epiKO mice. In particular, S100A8 gene promoter was induced by inflammation-related transcription factor NF-kB p65 in cultured human keratinocytes. In contrast, VDR was repressed the NF-kB-meditated S100A8 promoter activation. Furthermore, we established the systemic and epidermis-specific S100 A8 KO mice. Analyses of these mouse lines suggests that S100A8 might be involved in epidermal defects of VDR epiKO mice.
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