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The effect of oral immunotherapy on class switching and change in avidity of allergen-specific immunoglobulin

Research Project

Project/Area Number 16K19648
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionThe University of Tokushima

Principal Investigator

SUGIMOTO Mayumi  徳島大学, 大学院医歯薬学研究部(医学系), 助教 (20771314)

Research Collaborator KIDO Hiroshi  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords食物アレルギー / 経口免疫療法 / 抗原特異的免疫グロブリン / アレルギー / 食品
Outline of Final Research Achievements

This study aims to identify the factors which predict the therapeutic effects and to elucidate the mechanism of oral immunotherapy (OIT) by measuring serum allergen-specific immunoglobulins. The response to OIT was associated with significant increases in serum allergen-specific IgG1 levels after up-dosing phase and high baseline IgA levels, compared with small changes in immunoglobulin response in low-responders. The characteristic IgG1 changes and IgA levels in the responders could be potentially useful biomarkers for the prediction of positive clinical response to OIT. The avidity of allergen-specific IgE after OIT was also significantly decreased in high-responders, suggesting that it might be involved in the mechanism of OIT.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Differential response in allergen-specific IgE, IgGs, and IgA levels for predicting outcome of oral immunotherapy.2016

    • Author(s)
      Mayumi Sigimoto, Norio Kamemura, Mizuho Nagao, Makoto Irahara, Shoji Kagami, Takao Fujisawa, and Hiroshi Kido.
    • Journal Title

      Pediat. Allegy Immunol.

      Volume: 27 Issue: 3 Pages: 276-282

    • DOI

      10.1111/pai.12535

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CLINICAL APPLICATION OF A HIGHLY SENSITIVE ALLERGEN MICROARRAY WHICH CAN MONITOR IMMUNE RESPONSE BY IMMUNOGLOBULIN CLASS SWITCHING2016

    • Author(s)
      Kido Hiroshi, Sugimoto Mayumi
    • Journal Title

      Japanese Journal of Allergology

      Volume: 65 Issue: 6 Pages: 764-769

    • DOI

      10.15036/arerugi.65.764

    • NAID

      130005166055

    • ISSN
      0021-4884, 1347-7935
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 鶏卵少量負荷試験とその後の摂取状況に関する検討2017

    • Author(s)
      杉本真弓、苛原誠、香美祥二
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳児期におけるイムノグロブリンクラススイッチの進展と抗原親和性2017

    • Author(s)
      苛原誠、佐々木陽平、品原和加子、杉本真弓、香美祥二、木戸博
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 6種除去療法が有用であった好酸球性胃腸炎の1例2017

    • Author(s)
      佐々木亜由美、杉本真弓、戸梶成美、苛原誠、寺田知正、香美祥二
    • Organizer
      第54回日本小児アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生後6ヵ月までの母乳栄養児と人工乳栄養児の抗原摂取量の違いを背景とした湿疹誘発IgEクラススイッチパターンの違い2017

    • Author(s)
      木戸博、苛原誠、品原和加子、杉本真弓、香美祥二
    • Organizer
      第54回日本小児アレルギー学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多抗原の食物除去が身体発育に与える影響2016

    • Author(s)
      苛原誠,杉本真弓,香美祥二
    • Organizer
      第53回日本小児アレルギー学会
    • Place of Presentation
      ベイシア文化ホール、群馬県前橋市
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 重症食物アレルギー児に対する経口免疫療法の長期経過について2016

    • Author(s)
      桑原優,長尾みづほ,伊藤卓洋,平山淳也,貝沼圭吾,杉本真弓,藤澤隆夫
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京都千代田区
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 0-6ヵ月乳児のアレルゲン特異的抗体価イムノグロブリンクラススイッチの検討2016

    • Author(s)
      苛原誠,佐々木陽平,品原和加子,杉本真弓,香美祥二,木戸博
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京都千代田区
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳児期の卵白アレルゲン特異的IgE抗体の低から高親和性変化の検討2016

    • Author(s)
      苛原誠,佐々木陽平,品原和加子,杉本真弓,香美祥二,木戸博
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京都千代田区
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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