Assessment of Stereotactic Micro beam Radiation Therapy

• Project/Area Number: 16K19818
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: MUKUMOTO Naritoshi 神戸大学, 医学部附属病院, 特命技術員 (70634278)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: マイクロビーム / 放射光 / SPring-8 / 耐容線量 / 超高線量率X線照射 / 定位放射線治療 / 放射線治療 / 定位照射

Outline of Final Research Achievements

Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in short period of time with a single fraction using arrays of micro-slit beam radiation therapy. In this study, we have challenged to treat multiple metastatic lung tumors by applying MRT to mouse tumor-bearing right lung with comparing to the broad beam treatment from the same radiation source.
According to microscopic observations, the areas of tumor on the slides were reduced to one-third compared to the unirradiated region in the slides of 120 Gy MRT while the total lung area was not collapsed and maintained its original size.
Such high doses of MRT can diminish the tumor volumes without breaching of lung tissue scaffoldings. There is a good possibility that MRT would control the growth of metastatic lung tumors.

Research Products

• [Journal Article] Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy. (2017)
  • Author(s): Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Yasuyuki Shimizu, Saki Osuga, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Yasushi Miura, Keiji Umetani, Takeshi Kondoh, Ryohei Sasaki,
  • Journal Title: J Radiat Res Volume: 58(1) Issue: 1 Pages: 17-23
  • DOI: 10.1093/jrr/rrw065
  • NAID: 120006220810
  • Peer Reviewed / Open Access
• [Journal Article] MGDG extracted from spinach enhances the cytotoxicity of radiation in pancreatic cancer cells. (2016)
  • Author(s): Akasaka H, Mizushina Y, Yoshida K, Ejima Y, Mukumoto N, Wang T, Inubushi S, Nakayama M, Wakahara Y, Sasaki R.
  • Journal Title: Radiat Oncol Volume: 11（１） Issue: 1 Pages: 153-153
  • DOI: 10.1186/s13014-016-0729-0
  • NAID: 120005898712
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Assessment of adaptive radiation therapy with deformable image registration software (2017)
  • Author(s): Naritoshi Mukumoto, Ryuichi Yada, Yasuyuki Shimizu, Keisuke Okumura, Tianyuan Wang, Saki Osuga, Hiroaki Akasaka, Yuichi Aoyama, Ryohei Sasaki
  • Organizer: AAPM 59th Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] Influence of the applied voltage on the ion recombination correction factor using the two-voltage technique in FFF beams (2017)
  • Author(s): Ryuichi Yada, Naoki Hayashi, Naritoshi Mukumoto, Hiroaki Akasaka, Ryohei Sasaki
  • Organizer: AAPM 59th Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] CT、MRIでの検討に基づく過酸化チタンナノ粒子を用いたTheranostic drugの基礎的検討 (2017)
  • Author(s): 赤坂 浩亮、中山 雅央、椋本 成俊、荻野 千秋、西村 勇哉、森田 健太、京谷 勉輔、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] メタボロミクスにおける放射線消化管機能不全指標の解明 (2017)
  • Author(s): 大須賀 彩希、犬伏 祥子、赤坂 浩亮、椋本 成俊、清水 康之、王 天縁、宮脇 大輔、吉田 賢史、石原 武明、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 金ナノ粒子との比較による過酸化チタンナノ粒子の放射線増感効果の有用性の検討 (2017)
  • Author(s): 中山 雅央、赤坂 浩亮、椋本 成俊、荻野 千秋、西村 勇哉、森田 健太、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 還元型コエンザイムQ10による腸管の有害事象軽減の検討 (2017)
  • Author(s): 清水 康之、椋本 成俊、赤坂 浩亮、矢田 隆一、王 天縁、大須賀 彩希、宮脇 大輔、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 頭頸部領域における固定具を用いたCT画像とMR画像のRegistration精度評価 (2017)
  • Author(s): 奥村 圭祐、椋本 成俊、京谷 勉輔、西谷 隆治、表田 真弓、赤坂 浩亮、青山 裕一、日下 亜起子
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] Novel application of Dual Energy CT for the suppression of metal artifact in Radiotherapy (2017)
  • Author(s): 王 天縁、石原 武明、吉田 直碁、角谷 賢一朗、宮脇 大輔、吉田 賢史、赤坂 浩亮、椋本 成俊、矢田 隆一、青山 裕一、高橋 哲、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] Elucidation of the radiation gastrointestinal dysfunction index using metabolomics (2016)
  • Author(s): Saki Osuga, Sachiko Inubushi, Yasuo Ejima, Hiroaki Akasaka, Yasuyuki Shimizu, Tianyuan Wang, Naritoshi Mukumoto, Daisuke Miyawaki, Kenji Yoshida, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] Physical analysis of the animal irradiation system in the Kobe University (2016)
  • Author(s): Yasuyuki Shimizu, Daisuke Miyawaki, Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Yuki Wakahara, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] Effectiveness of micro-slit beam radiation therapy for multiplelung-metastatic tumor (2016)
  • Author(s): Yuki Wakahara, Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Ray Corry Uchida, Kenji Yoshida, Takeaki Ishihara, Daisuke Miyawaki, Keiji Umetani, Yasuo Ejima, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] Next-stage Bioabsorbable Spacer in Particle Therapy (2016)
  • Author(s): Tianyuan Wang, Hiroaki Akasaka, Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Sachiko Inubushi, Naritoshi Mukumoto, Takumi Fukumoto, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] The process of thedetermination of Dosimetric leaf gap and Transmission for VMAT using TrueBeam STx (2016)
  • Author(s): Hiroaki Akasaka, Toshiaki Minami, Ryuichi Yada, Naritoshi Mukumoto, Tianyuan Wang, Shimizu Yasuyuki, Saki Osuga, Yuki Wakahara, Takeaki Ishihara, Yuichi Aoyama, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] 日本放射線腫瘍学会第29回学術大会 (2016)
  • Author(s): Yuichi Aoyama, Naritoshi Mukumoto, Takaharu Nishitani, Toshiaki Minami, Mayumi Omoteda, Masanori Miyamoto, Keisuke Okumura, Tomohiro Inoue, Hiroaki Akasaka, Ryuichi Yada, Hideaki Kawamitsu
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] Assessment of dose calculation accuracy with lung heterogeneity phantom (2016)
  • Author(s): Naritoshi Mukumoto, Ryuichi Yada, Keisuke Okumura, Takuro Nishio, Hiroaki Akasaka, Yasuyuki Shimizu, Takaharu Nishitani, Yuichi Aoyama, Daisuke Miyawaki, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] 肺不均質ファントムにおける線量計算アルゴリズム精度の検討 (2016)
  • Author(s): 椋本成俊、矢田隆一、赤坂浩亮、清水康之、奥村圭祐、王天縁、大須賀彩希、若原悠希、青山裕一、佐々木良平
  • Organizer: 第112回日本医学物理学会学術大会
  • Place of Presentation: 沖縄
  • Year and Date: 2016-09-08